Now showing items 2793-2812 of 5604

    • Is a modified Global Trigger Tool method using automatic trigger identification valid when measuring adverse events? A comparison of review methods using automatic and manual trigger identification 

      Mevik, Kjersti; Hansen, Tonje Elisabeth; Deilkås, Ellen C Tveter; Ringdal, Alexander; Vonen, Barthold (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-08)
      <p><i>Objectives - </i>To evaluate a modified Global Trigger Tool (GTT) method with manual review of automatic triggered records to measure adverse events. <p><i>Design - </i>A cross-sectional study was performed using the original GTT method as gold standard compared to a modified GTT method. <p><i>Setting - </i>Medium size hospital trust in Northern Norway. <p><i>Participants - </i>One thousand ...
    • Is age at menarche associated with total mortality? The Tromsø Study 

      Lundblad, Marie Wasmuth; Jacobsen, Bjarne K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-01)
      <p><i>Purpose</i>: Early age at menarche (AAM) has been associated with increased mortality and morbidity, including premature death from all causes, breast cancer and cardiovascular diseases. The aim of this study was to examine the association between AAM and all-cause mortality.</p> <p><i>Subjects and methods</i>: A total of 12,409 women aged 25–94 years who took part in the fourth Tromsø Study ...
    • Is Beauty in the Face of the Beholder? 

      Laeng, Bruno; Vermeer, Oddrun; Sulutvedt, Unni (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Opposing forces influence assortative mating so that one seeks a similar mate while at the same time avoiding inbreeding with close relatives. Thus, mate choice may be a balancing of phenotypic similarity and dissimilarity between partners. In the present study, we assessed the role of resemblance to Self’s facial traits in judgments of physical attractiveness. Participants chose the most attractive ...
    • Is ignorance bliss? : young men's lack of knowledge and concern for their health 

      Lind, Marius (Master thesis; Mastergradsoppgave, 2009-02-01)
      Testicular cancer is an increasing health concern in Norway. It afflicts young men who often think they are impervious to serious illness, causing them to delay help-seeking. This is a major concern for the health care system, as the prognosis takes a steep fall if the cancer has had time to metastasise. The present study assessed the knowledge and awareness level of testicular cancer and testicular ...
    • Is inter-rater reliability of Global Trigger Tool results altered when members of the review team are replaced? 

      Mevik, Kjersti; Griffin, Frances A.; Hansen, Tonje Elisabeth; Deilkås, Ellen C Tveter; Vonen, Barthold (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-12)
      <p><i>Objective - </i>To evaluate the inter-rater reliability of results from Global Trigger Tool (GTT) reviews when one of the three reviewers remains consistent, while one or two reviewers rotate. <p><i>Design - </i>Comparison of results from retrospective record review performed as a cross-sectional study with three review teams each consisting of two non-physicians and one physician; Team I ...
    • Is the operative delivery rate in low-risk women dependent on the level of birth care? : a randomised controlled trial 

      Bernitz, Stine; Rolland, Rune; Blix, Ellen; Jacobsen, Morten; Sjøborg, Katrine Dønvold; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Objective: To investigate possible differences in operative delivery rate among low-risk women, randomised to an alongside midwifery-led unit or to standard obstetric units within the same hospital. Design: Randomised controlled trial. Setting: Department of Obstetrics and Gynaecology, Østfold Hospital Trust, Tromsø, Norway. Population: A total of 1111 women assessed to be at low risk at onset ...
    • Is there a negative impact of winter on mental distress and sleeping problems in the sub-arctic? 

      Johnsen, May Trude; Wynn, Rolf; Bratlid, trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
    • Is there a weekly pattern for health information searching and is the pattern unique to health topics? 

      Gabarron, Elia; Lau, Annie YS; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12)
      Background: Online health information–seeking behaviors have been reported to be more common at the beginning of the workweek. This behavior pattern has been interpreted as a kind of “healthy new start” or “fresh start” due to regrets or attempts to compensate for unhealthy behavior or poor choices made during the weekend. However, the observations regarding the most common health information–seeking ...
    • Is traditional Chinese medicine recommended in Western medicine clinical practice guidelines in China? A systematic analysis 

      Ren, Jun; Li, Xun; Sun, Jin; Han, Mei; Yang, Guo-Yan; Li, Wen-Yuan; Robinson, Nicola; Lewith, George; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-03)
      Background: Evidence-based medicine promotes and relies on the use of evidence in developing clinical practice guidelines (CPGs). The Chinese healthcare system includes both traditional Chinese medicine (TCM) and Western medicine, which are expected to be equally reflected in Chinese CPGs. <p>Objective: To evaluate the inclusion of TCM-related information in Western medicine CPGs developed ...
    • Iscenesettelse av kulturelt demokrati: sett i lys av omsorgsregimer 

      Gjærum, Rikke Gürgens (Chapter; Bokkapittel, 2017)
      Dette kapittelet utforsker hvordan det kulturelle demokratiet iscenesettes i omsorgstjenester for mennesker med demens, for borgere på flukt og for psykiatriske pasienter i dagens Velferds-Norge. Kunstens potensial til å fremstå som et alternativt omsorgsregime diskuteres i lys av kunstdidaktikk, marginalisering og det Eichmannske problem. Kapittelet bygger på en studie bestående av tre analyser ...
    • Ischemic stroke and risk of venous thromboembolism in the general population. The Tromsø study 

      Rinde, Ludvig Balteskard (Master thesis; Mastergradsoppgave, 2017-10-21)
      Background: Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort. Methods and Results: Participants (n=30 002) were recruited from ...
    • Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromsø Study 

      Balteskard Rinde, Ludvig; Småbrekke, Birgit; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen Hald, Erin; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-07)
      <i>Background</i> - Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort.<p> <p><i>Methods and Results</i> - Participants (n=30 ...
    • Ischemic stroke in a general population: Time trends in incidence, case fatality and the impact of risk factors. 

      Vangen-Lønne, Anne Merete (Doctoral thesis; Doktorgradsavhandling, 2017-10-13)
      About 80-85% of all strokes are due to reduced blood flow to the brain (ischemic strokes). Lack of knowledge regarding time trends in incidence and case fatality of ischemic stroke in Norway represented a main motivation for this study. Data from the Tromsø Study, following >40,000 attendees from six surveys through 2012, provided an excellent opportunity to reveal time trends of ischemic stroke and ...
    • Isocaloric substitution of carbohydrates with protein: The association with weight change and mortality among patients with type 2 diabetes 

      Campmans-Kuijpers, Marjo J.E.; Sluijs, Ivonne; Nöthlings, Ute; Freisling, Heinz; Overvad, Kim; Weiderpass, Elisabete; Fagherazzi, Guy; Kühn, Tilman; Katzke, Verena A.; Mattiello, Amalia; Sonestedt, Emily; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Spijkerman, Annemieke M.W.; Barricarte, Aurelio; Ricceri, Fulvio; Chamosa, Saioa; Johansson, Ingegerd; Winkvist, Anna; Tjønneland, Anne; Sluik, Diewertje; Boeing, Heiner; Beulens, Joline W.J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-18)
      Background: The health impact of dietary replacement of carbohydrates with protein for patients with type 2 diabetes is still debated. This study aimed to investigate the association between dietary substitution of carbohydrates with (animal and plant) protein and 5-year weight change, and all-cause and cardiovascular (CVD) mortality risk in patients with type 2 diabetes. <p>Methods: The study ...
    • The isolated perfused human skin flap model: A missing link in skin penetration studies? 

      Ternullo, Selenia; de Weerd, Louis; Flaten, Gøril Eide; Holsæter, Ann Mari; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-05)
      Development of effective (trans)dermal drug delivery systems requires reliable skinmodels to evaluate skin drug penetration. The isolated perfused human skin flap remainsmetabolically active tissue for up to 6 h during in vitro perfusion. We introduce the isolated perfused human skin flap as a close-to-in vivo skin penetration model. To validate the model's ability to evaluate skin drug penetration ...
    • Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart 

      Pedersen, Tina Myhre; Boardman, Neoma; Hafstad, Anne Dragøy; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
      Although murine models for studying the development of cardiac dysfunction in diabetes mellitus are well established, their reported cardiac phenotypes vary. These reported divergences may, in addition to the severity of different models, also be linked to the methods used for cardiac functional assessment. In the present study, we examined the functional changes using conventional transthoracic ...
    • Isolation and Characterisation of Halogenated and Bioactive Compounds from Thalassospira sp. and Alteromonas sp. 

      Ali, Nadia Ghazi (Master thesis; Mastergradsoppgave, 2019-05-15)
      Bacterial natural products have contributed with a large part of the bioactive compounds that lead to drugs, and the biggest portion of the marketed antibiotics are bacterial products or their derivatives. Marine bacteria are not yet investigated to the same extend as their terrestrial counterparts. Therefore, they are considered a promising source for novel bioactive metabolites for drug development, ...
    • Isolation and characterization of anti-inflammatory compounds from marine organisms : Eucratea loricata and Echinus esculentus 

      Do, Minh-Anh Thuy (Master thesis; Mastergradsoppgave, 2012-05-19)
      In the last decade, the investigation of marine natural products has resulted in a remarkable number of compounds with promising biological activities. Marine natural products have been shown to display antibacterial, antifungal, anticancer, antiviral, antiparasitic, anti-inflammatory activity and several other pharmacological activities of benefit to humankind. In this project, an investigation ...
    • Isolation and characterization of antibacterial compounds from marine organisms 

      Thanki, Meera Satish (Master thesis; Mastergradsoppgave, 2010-06-17)
      Marine bioprospecting is a promising field of research that has gained interest worldwide for the past few decades, and can be characterised as a systematic and purpose oriented search for bioactive compounds or genetic material from marine sources. Several compounds have been isolated and some have found their way into the commercial market. The main aim of this master thesis was to investigate the ...