Now showing items 2813-2832 of 5626

    • Iscenesettelse av kulturelt demokrati: sett i lys av omsorgsregimer 

      Gjærum, Rikke Gürgens (Chapter; Bokkapittel, 2017)
      Dette kapittelet utforsker hvordan det kulturelle demokratiet iscenesettes i omsorgstjenester for mennesker med demens, for borgere på flukt og for psykiatriske pasienter i dagens Velferds-Norge. Kunstens potensial til å fremstå som et alternativt omsorgsregime diskuteres i lys av kunstdidaktikk, marginalisering og det Eichmannske problem. Kapittelet bygger på en studie bestående av tre analyser ...
    • Ischemic stroke and risk of venous thromboembolism in the general population. The Tromsø study 

      Rinde, Ludvig Balteskard (Master thesis; Mastergradsoppgave, 2017-10-21)
      Background: Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort. Methods and Results: Participants (n=30 002) were recruited from ...
    • Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromsø Study 

      Balteskard Rinde, Ludvig; Småbrekke, Birgit; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen Hald, Erin; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-07)
      <i>Background</i> - Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort.<p> <p><i>Methods and Results</i> - Participants (n=30 ...
    • Ischemic stroke in a general population: Time trends in incidence, case fatality and the impact of risk factors. 

      Vangen-Lønne, Anne Merete (Doctoral thesis; Doktorgradsavhandling, 2017-10-13)
      About 80-85% of all strokes are due to reduced blood flow to the brain (ischemic strokes). Lack of knowledge regarding time trends in incidence and case fatality of ischemic stroke in Norway represented a main motivation for this study. Data from the Tromsø Study, following >40,000 attendees from six surveys through 2012, provided an excellent opportunity to reveal time trends of ischemic stroke and ...
    • Isocaloric substitution of carbohydrates with protein: The association with weight change and mortality among patients with type 2 diabetes 

      Campmans-Kuijpers, Marjo J.E.; Sluijs, Ivonne; Nöthlings, Ute; Freisling, Heinz; Overvad, Kim; Weiderpass, Elisabete; Fagherazzi, Guy; Kühn, Tilman; Katzke, Verena A.; Mattiello, Amalia; Sonestedt, Emily; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Spijkerman, Annemieke M.W.; Barricarte, Aurelio; Ricceri, Fulvio; Chamosa, Saioa; Johansson, Ingegerd; Winkvist, Anna; Tjønneland, Anne; Sluik, Diewertje; Boeing, Heiner; Beulens, Joline W.J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-18)
      Background: The health impact of dietary replacement of carbohydrates with protein for patients with type 2 diabetes is still debated. This study aimed to investigate the association between dietary substitution of carbohydrates with (animal and plant) protein and 5-year weight change, and all-cause and cardiovascular (CVD) mortality risk in patients with type 2 diabetes. <p>Methods: The study ...
    • The isolated perfused human skin flap model: A missing link in skin penetration studies? 

      Ternullo, Selenia; de Weerd, Louis; Flaten, Gøril Eide; Holsæter, Ann Mari; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-05)
      Development of effective (trans)dermal drug delivery systems requires reliable skinmodels to evaluate skin drug penetration. The isolated perfused human skin flap remainsmetabolically active tissue for up to 6 h during in vitro perfusion. We introduce the isolated perfused human skin flap as a close-to-in vivo skin penetration model. To validate the model's ability to evaluate skin drug penetration ...
    • Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart 

      Pedersen, Tina Myhre; Boardman, Neoma; Hafstad, Anne Dragøy; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
      Although murine models for studying the development of cardiac dysfunction in diabetes mellitus are well established, their reported cardiac phenotypes vary. These reported divergences may, in addition to the severity of different models, also be linked to the methods used for cardiac functional assessment. In the present study, we examined the functional changes using conventional transthoracic ...
    • Isolation and Characterisation of Halogenated and Bioactive Compounds from Thalassospira sp. and Alteromonas sp. 

      Ali, Nadia Ghazi (Master thesis; Mastergradsoppgave, 2019-05-15)
      Bacterial natural products have contributed with a large part of the bioactive compounds that lead to drugs, and the biggest portion of the marketed antibiotics are bacterial products or their derivatives. Marine bacteria are not yet investigated to the same extend as their terrestrial counterparts. Therefore, they are considered a promising source for novel bioactive metabolites for drug development, ...
    • Isolation and characterization of anti-inflammatory compounds from marine organisms : Eucratea loricata and Echinus esculentus 

      Do, Minh-Anh Thuy (Master thesis; Mastergradsoppgave, 2012-05-19)
      In the last decade, the investigation of marine natural products has resulted in a remarkable number of compounds with promising biological activities. Marine natural products have been shown to display antibacterial, antifungal, anticancer, antiviral, antiparasitic, anti-inflammatory activity and several other pharmacological activities of benefit to humankind. In this project, an investigation ...
    • Isolation and characterization of antibacterial compounds from marine organisms 

      Thanki, Meera Satish (Master thesis; Mastergradsoppgave, 2010-06-17)
      Marine bioprospecting is a promising field of research that has gained interest worldwide for the past few decades, and can be characterised as a systematic and purpose oriented search for bioactive compounds or genetic material from marine sources. Several compounds have been isolated and some have found their way into the commercial market. The main aim of this master thesis was to investigate the ...
    • Isolation and characterization of antiviral compounds from marine organisms 

      Ammari, Yashar (Master thesis; Mastergradsoppgave, 2010-06-16)
      Metridium senile, Halocynthia pyriformis and ParaParastichopus tremulus were subjected to organic and aqueous extraction. The aqueous extract was made with water, while the organic was made with dichloromethane and methanol in 1:1 ratio. The aqueous and organic extracts were fractionated on reversed-phase HPLC and tested for antiviral activity against Herpes simplex virus-1. All the three organisms ...
    • Isolation and characterization of bioactive compounds from the marine hydrozoans Halecium muricatum and Halecium beanii 

      Korsmo, Kim André (Master thesis; Mastergradsoppgave, 2012-05)
      In the marine environment there is a great potential for discovering new commercial drugs, and marine bioprospecting has previously led to the discovery of drugs available for clinical use, like Yondelis ® and cytosine arabinoside. In this work two hydroids were tested for anticancer and antibacterial activity. The organic extracts from the two hydroids, Halecium muricatum and Halecium beanii, ...
    • Isolation and Characterization of Secondary Metabolites from Arctic Marine Hydroids 

      Harvey, Therese (Master thesis; Mastergradsoppgave, 2018-05-15)
      Marine bioprospecting is the systematic search for and discovery of products from Nature, with potential of being developed into commercially available pharmaceuticals. The ocean represents the largest habitat on Earth, and represent a great resource of organisms with unique biological and chemical diversity. The marine environment makes the living condition challenging. To survive these conditions, ...
    • Isolation and characterization of wax esters from Calanus finmarchicus 

      Andersen, Toril (Master thesis; Mastergradsoppgave, 2010-06-16)
      Calanus finmarchicus is a vast resource that until recently have been exploited to a minimal degree only. In the last few years harvesting and processing methods have been developed. There is a large market and great interest in products derived from marine oils. Most of the products today are derived from organisms at a high trophic level, i.e. products derived from cod liver oil. One disadvantage ...
    • Isolation, characterization and chondrogenic differentiation of adult stem cell-derived MUSE-cells 

      Johansen, Lars-Arne (Master thesis; Mastergradsoppgave, 2016-05-13)
      Articular cartilage is coating the layers of freely movable joints, enabling a smooth surface and acts resisting to forces. The tissue is aneural and avascular, and has a poor ability to selfrenew in cases of tissue damage. Therefore, cartilage lesions often lead to degenerative disorders such as osteoarthritis (OA). OA is considered the most common form of arthritis affecting people worldwide, ...
    • Isolering av villøse cytotrofoblaster fra humane, friske og fullgåtte placenta 

      Heide, Gøril (Master thesis; Mastergradsoppgave, 2011-09-15)
      Det er et paradoks at fosteret, som representerer fremmed vev, ikke avstøtes av morens immunsystem ved implantasjon. Stedsspesifikk suppresjon av den maternelle immunresponsen er foreslått som forklaring, og flere mekanismer for dette er kjent. Føtal og neonatal trombocytopeni (NAIT) er et av tilfellene hvor maternell immunisering kan føre til ødeleggelse av fosterets celler, i dette tilfellet ...
    • Isolering og karakterisering av antibakterielle forbindelser i sjøstjernene: Urasterias linckii, Solaster endeca og Crossaster papposus 

      Ngo, Thong Huu (Master thesis; Mastergradsoppgave, 2009-06)
      Antibakteriell aktivitet mot Gram positive og Gram negative bakterier er påvist i ekstrakter av celler og plasma fra Solaster endeca, Crossaster papposus og Urasterias Linckii. Det har også blitt påvist antibakteriell aktivitet mot Gram negative bakterier i ekstrakter av hel kropp fra Solaster endeca og Croassaster papposus. Materialet ble grovekstrahert med 60 % Acetonitril, videre ble vannfase og ...
    • Isolering og karakterisering av forbindelser med anticancereffekt fra tre ulike marine organismer 

      Jalal, Shwan Hiwa (Master thesis; Mastergradsoppgave, 2010-06-16)
      Marin bioprospektering er i hurtig fremmarsj både i Norge og på verdensbasis. Det kan defineres som en formålrettet og systematisk leting etter bestander, bioaktive forbindelser eller gener i marine organismer med sikte på utvikling av et produkt som er kommersielt eller samfunnsmessige viktige. Målet med denne oppgaven er å lete etter forbindelser med anticancereffekt i ekstrakter av tre ulike ...
    • Isolering og vurdering av invariable NKT-cellers dreperfunksjon 

      Simonsen, Karsten Holt (Master thesis; Mastergradsoppgave, 2012-06-01)
      Invariable Natural Killer T (iNKT) celler er en undergruppe av T-lymfocytter som interagerer med det non-polymorfe CD1d-molekylet og aktiveres av glykosphingolipid-antigener (som αGalCer ). iNKT celler kan produsere rikelige mengder immunoregulerende cytokiner som påvirker nivået av aktivering til mange typer celler og kan også drepe andre celler. Målet for denne oppgaven var å undersøke om iNKT-celler ...