γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system (CNS). Dysfunctional GABAergic neurotransmission is associated with numerous neurological and neuropsychiatric disorders. The GABA_B receptor (GABA_B-R) is a heterodimeric class C G protein-coupled receptor (GPCR) comprised of GABA_B1a/b and GABA_B2 subunits. The ...

<i>Purpose</i>: Norway has experienced an unexplained, steep increase in colorectal cancer (CRC) incidence in the last half-century, with large differences across its counties. We aimed to determine whether geographical distribution of lifestyle-related CRC risk factors can explain these geographical differences in CRC incidence in Norwegian women.<p><p> <i>Methods</i>: We followed a nationally ...

Mitochondria are the main energy producing units (organelles) in cardiac cells (cardiomyocytes). Cardiomyocytes have especially high mitochondrial content due to the heart’s continuous energy-intensive pumping. Studies of heart disease (such as heart failure) indicate that mitochondrial dysfunction is central to disease progression. There are many cellular mechanisms that protect mitochondria from ...

<p>Unsafe medical practices and incidents where safety hazards cause harm to patients occur daily in general practice. The costs to society, health care personnel and individual patients are substantial and deserve attention. “Hazards” can be regarded as local error-producing factors, latent failures, which create conditions for unsafe medical practice to take place. “Harm” occurs when these conditions ...

Increased knowledge about physical activity(PA) and dietary choises could be valuable when preventive measures against overweight are planned and carried out. The main aim of the thesis was therefore to explore PA and dietary choises among adolescents in Troms County, furthermore to investigate if there were an association between these two health-related behaviors. The thesis is a cross-sectional ...

Introduction - It is important to understand the factors impacting the quality of services provided through community pharmacies. Exploring how key stakeholders perceive good quality in these services is a logical first step. This could also inform the development of quality measures, such as quality indicators (QIs).<p> <p>Aim - To identify key stakeholders' perspectives on the quality of services ...

Two potentially costly errors are common in sequential investment decisions: sticking too long to a failing course of action (escalation of commitment), and abandoning a successful course of action prematurely. Past research has mostly focused on escalation of commitment, and identified three critical determinants: personal responsibility, preferences for prior decisions, and decision framing. We ...

Background: Previous studies have found that the use of complementary and alternative medicine (CAM) is associated with several characteristic, such as female gender, higher education and higher income. However, studies investigating the relationship between alcohol consumption patterns and different CAM approaches have so far been limited. Harmful use of alcohol has detrimental consequences to ...

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare disease that may cause serious bleedings in the fetus or neonate of a woman who has developed antibodies against the fetus’ platelets. Development of FNAIT has been linked to the presence of platelet reactive CD4 T cells that help B cells to develop into antibody producing plasma cells. To be able to conduct research on such T cells, ...

N‐methyl‐d‐aspartate receptors (NMDAR) are widely expressed in the brain. GluN2B subunit‐containing NMDARs has recently attracted significant attention as potential pharmacological targets, with emphasis on the functional properties of allosteric antagonists. We used primary cultures from chicken embryo forebrain (E10), expressing native GluN2B‐containing NMDA receptors as a novel model system. ...