Now showing items 4432-4451 of 5482

    • The Role of Adherence and Retreatment in De Novo Emergence of MDR-TB 

      Cadosch, Dominique; Abel zur Wiesch, Pia; Kouyos, Roger; Bonhoeffer, Sebastian (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Treatment failure after therapy of pulmonary tuberculosis (TB) infections is an important challenge, especially when it coincides with de novo emergence of multi-drug-resistant TB (MDR-TB). We seek to explore possible causes why MDR-TB has been found to occur much more often in patients with a history of previous treatment. We develop a mathematical model of the replication of Mycobacterium tuberculosis ...
    • The role of complement and Toll-like receptors in thromboinflammation 

      Landsem, Anne (Doctoral thesis; Doktorgradsavhandling, 2019-05-23)
      Sepsis fra bakterier er en alvorlig tilstand som årlig krever mange liv. Selv om immunsystemet og det hemostatiske system samarbeider for å bekjempe bakterieinfeksjoner, kan dette i noen tilfelle skyte over mål. Derfor har vi i denne studien undersøkt om bakterieindusert aktivering av koagulasjon og inflammasjon reduseres av en dobbelthemming av komplementsystemet og toll-like reseptorer (TLR). Det ...
    • The Role of electronic nursing documentation for continuity of care in short-time wards 

      Smáradóttir, Berglind Fjóla (Master thesis; Mastergradsoppgave, 2009-05)
      This paper provides an understanding on the role of the electronic nursing documentation, as an integrated part of the Electronic Patient Record (EPR) in a heterogeneous work practice hospital unit characterized by short-time stay. The aim is to find what role the electronic nursing documentation plays in the communication and collaboration between health care professionals and the different wards ...
    • The Role of Estrogen Receptor β (ERβ) in the Establishment of Hierarchical Social Relationships in Male Mice 

      Nakata, Mariko; Ågmo, Anders j; Satoshi, Shoko; Ogawa, Sonoko (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-22)
      Acquisition of social dominance is important for social species including mice, for preferential access to foods and mates. Male mice establish social rank through agonistic behaviors, which are regulated by gonadal steroid hormone, testosterone, as its original form and aromatized form. It is well known that estrogen receptors (ERs), particularly ER α (ERα), mediate effects of aromatized testosterone, ...
    • Role of Extracellular Vesicles in the Pathogenesis of Venous Thromboembolism 

      Jamaly, Simin (Doctoral thesis; Doktorgradsavhandling, 2018-06-13)
      Venous thromboembolism (VTE) is a common disease with an incidence of 1–2 per 1000 individuals. VTE is a collective term for deep vein thrombosis and pulmonary embolism. Extracellular vesicles (EVs) are lipid-membrane-bound spherical vesicles that bud off from the cells upon activation and apoptosis. Their size varies between 30 nm and 1 μm. Recent advances in experimental and observational studies ...
    • The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis 

      Snapkov, Igor; Öqvist, Carl Otto; Figenschau, Yngve Anton; Kogner, Per; Johnsen, John Inge; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-18)
      Background: Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor mainly expressed by the cells of myeloid origin, where it mediates the innate immune response to bacterial formylated peptides. High expression of FPR1 has been detected in various cancers but the function of FPR1 in tumorigenesis is poorly understood. Methods: Expression of FPR1 in neuroblastoma cell lines and primary ...
    • The role of general practitioners in the pre hospital setting, as experienced by emergency medicine technicians: a qualitative study 

      Hjortdahl, Magnus; Zakariassen, Erik; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      <p><i>Background:</i>Together with the ambulances staffed with emergency medical technicians (EMTs), general practitioners(GPs) on call are the primary resources for handling emergencies outside hospitals in Norway. The benefit of the GP accompanying the ambulance to pre-hospital calls is a matter of controversy in Norway. The purpose of the present study was to gain better insight into the EMT’s ...
    • The role of health extension workers in improving utilization of maternal health services in rural areas in Ethiopia: a cross sectional study 

      Medhanyie, Araya; Spigt, Marcus; Kifle, Yohannes; Schaay, Nikki; Sanders, David; Blanco, Roman; GeertJan, Dinant; Berhane, Yemane (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Community health workers are widely used to provide care for a broad range of health issues. Since 2003 the government of Ethiopia has been deploying specially trained new cadres of community based health workers named health extension workers (HEWs). This initiative has been called the health extension program. Very few studies have investigated the role of these community health workers in improving ...
    • The role of inflammatory pathways in neuroblastoma tumorigenesis 

      Snapkov, Igor (Doctoral thesis; Doktorgradsavhandling, 2016-09-23)
      Neuroblastoma er en type nervecellekreft hos barn. Den har en svært kompleks biologisk heterogenisitet og er i noen tilfeller resistent mot cellegift. Den aggressive varianten av neuroblastoma er vanskelig å behandle, og dødeligheten er relativ høy. Det betyr at behovet for alternative behandlingsstrategier er stort. Gjennom økt biologisk forståelse kan man utvikle mer målrettede behandlinger som ...
    • The role of integration in health-based information infrastructures 

      Ellingsen, Gunnar Adelsten; Røed, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
    • Role of Laeverin in the pathophysiology of preeclampsia 

      Nystad, Mona (Doctoral thesis; Doktorgradsavhandling, 2018-05-11)
      Preeclampsia is a pregnancy-specific disease, affecting 5-10% of human pregnancies worldwide. It is defined as new-onset hypertension after 20 weeks of gestation with either proteinuria and/or organ failure. Laeverin is a membrane-bound aminopeptidase exclusively expressed in the placenta. Our previous studies revealed a significant upregulation of laeverin mRNA in preeclamptic placentas, building ...
    • The role of Merkel cell polyomavirus and other human polyomaviruses in emerging hallmarks of cancer 

      Moens, Ugo; Rasheed, Kashif; Abdulsalam, Ibrahim; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-10)
      Polyomaviruses are non-enveloped, dsDNA viruses that are common in mammals, including humans. All polyomaviruses encode the large T-antigen and small t-antigen proteins that share conserved functional domains, comprising binding motifs for the tumor suppressors pRb and p53, and for protein phosphatase 2A, respectively. At present, 13 different human polyomaviruses are known, and for some of them ...
    • The role of MMP-2 and MMP-14 in cell migration and invasion 

      Okoli, Ndidiamaka Chinelo (Master thesis; Mastergradsoppgave, 2014-02-03)
      Cancer is becoming a global epidemic in recent times and can affect different organs in the body and even more worrying is that they do not have a common cause. Several factors have been implicated in the onset and spread of cancers, one of which are the metalloproteinases (MMPs). The MMPs utilize the same strategy they employ in normal physiological processes in pathology, thus creating a dilemma ...
    • Role of monocyte procoagulant functions in the pathophysiology of arterial and venous thrombosis 

      Goolyam Basavaraj, Manjunath (Doctoral thesis; Doktorgradsavhandling, 2011-12-16)
      Monocytter, en klasse hvite blodlegemer i blodet, spiller en sentral rolle i kroppens immunforsvar og for blodets evne til å levre seg og danne en blodpropp. De kan ved stimulering, som ved sykelige tilstander, uttrykke vevsfaktor (TF) på celleoverflaten. TF er ansvarlig for å sette i gang blodproppmekanismen. En blodpropp kan dannes i kroppens samleårer (vener – kalles da dyp venøs trombose eller ...
    • The role of NADPH oxidases in diabetic cardiomyopathy 

      Hansen, Synne Simonsen; Aasum, Ellen; Hafstad, Anne Dragøy (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-25)
      Systemic changes during diabetes such as high glucose, dyslipidemia, hormonal changes and low grade inflammation, are believed to induce structural and functional changes in the cardiomyocyte associated with the development of diabetic cardiomyopathy. One of the hallmarks of the diabetic heart is increased oxidative stress. NADPH-oxidases (NOXs) are important ROS-producing enzymes in the cardiomyocyte ...
    • The role of pharmacoepidemiological studies in the market withdrawal of carisoprodol (Somadril®) in Europe. 

      Bramness, Jørgen; Skurtveit, Svetlana; Buajordet, Ingebjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)
    • Role of respondents' education as a mediator and moderator in the association between childhood socio-economic status and later health and wellbeing 

      Sheikh, Mashhood Ahmed; Abelsen, Birgit; Olsen, Jan Abel (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-18)
    • A role of Sp1 binding motifs in basal and large T-Antigen-induced promoter activities of human polyomavirus HPyV9 and its variant UF-1 

      Moens, Ugo; Song, Xiaobo; Van Ghelue, Marijke; Lednicky, John A.; Ehlers, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-14)
      Human polyomavirus 9 (HPyV9) was originally detected in the serum of a renal transplant patient. Seroepidemiological studies showed that ~20-50% of the human population have antibodies against this virus. HPyV9 has not yet been associated with any disease and little is known about the route of infection, transmission, host cell tropism, and genomic variability in circulating strains. Recently, the ...
    • The role of Staphylococcus aureus in allergic disease and cross-reactivity in fish allergy 

      Sørensen, Martin (Doctoral thesis; Doktorgradsavhandling, 2017-09-29)
      Aims: The aims was to describe prevalence`s of allergic disease in adolescents and study associations between allergic diseases and Staphylococcus aureus. Secondly, to study cross-reactivity in fish allergic children and the utility of existing and novel tests for fish allergy. Material and Methods: Prevalence of allergic diseases and associations to Staphylococcus aureus was studied in a cross-sectional ...
    • The role of steroid hormone receptors in prostate cancer. A study of estrogen- and progesterone receptors in adenocarcinoma of the prostate 

      Grindstad, Thea Karoline Walstad (Doctoral thesis; Doktorgradsavhandling, 2018-06-15)
      Steroid hormones and their receptors are vital for numerous physiological processes in the human body, but also related to the development of several malignancies. One such receptor strongly associated with prostate cancer, is the androgen receptor. Other steroid hormone receptors are also implicated in prostate cancer, their role, however, remains to be defined. Using immunohistochemistry and tissue ...