English
norskBlar i tittel Det helsevitenskapelige fakultet
Viser treff 4472-4491 av 10096
-
Identification of Children of Mentally Ill Patients and Provision of Support According to the Norwegian Health Legislation: A 11-Year Review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-14)Background: According to amended legislation implemented in Norway in 2010, personnel in healthcare services for adults are obligated to identify patients’ minor children and to assess the family situation. Health personnel is also obligated to contribute to adequate support to families affected by parental mental illness or substance use disorders. The intention behind the amendment was to ... -
Identification of Children of Parents With Mental Illness: A Necessity to Provide Relevant Support
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-08)<p><i>Background - </i>The main objective of this study was to identify and describe core life circumstances of children with mentally ill parents (COPMI) and their parents. Knowledge about COPMI aged 0–17 years is necessary, as assessment of the risk and protective factors in their lives provide solid background for preventive interventions. <p><i>Methods - </i>Participants (<i>N</i> = 422) were ... -
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)<b>Objective:</b> Endothelial cell (EC) dysfunction is a well-established response to cardiovascular disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC signaling and behavior, leading to arterial and venous disease development. Here, we aimed to identify biomarker panels for the assessment of EC dysfunction, which could be useful for risk stratification or to monitor ... -
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-27)Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10−8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative ... -
Identification of N-terminal and C-terminal peptides in proteomics
(Master thesis; Mastergradsoppgave, 2018-05-15)Background: Identifying modifications made to terminal parts of proteins are very useful in understanding diseases and other out of the ordinary biological states. This thesis has focused on developing methods for enriching N-terminal and C-terminal peptides from a complex protein mixture, so that analysis of these samples can give better, more comprehensive and more reproducible results. -
Identification of novel roles and new modes of regulation for the atypical MAP kinases ERK3 and ERK4
(Doctoral thesis; Doktorgradsavhandling, 2015-11-13)The atypical MAP kinases ERK3 and ERK4 are the main characters in this study. ERK3 and ERK4 were for long considered as orphan proteins without known upstream activators. However, in 2011 two studies had detected that group I p-21 protein activated kinase (PAKs) can constitutively phosphorylate ERK3 and ERK4 in their activation loop. The only well-characterized substrate for ERK3 and ERK4 at that ... -
Identification of novel serotonin transporter compounds by virtual Screening
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-02-12)The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) plays an essential role in the termination of serotonergic neurotransmission by removing 5-HT from the synaptic cleft into the presynaptic neuron. It is also of pharmacological importance being targeted by antidepressants and psychostimulant drugs. Here, five commercial databases containing approximately 3.24 million drug-like compounds ... -
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-12)The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to breast cancer aggressiveness and proposed Wnt/PCP signalling as a therapeutic target. Here we show that the archetypal Wnt/PCP protein VANGL2 is overexpressed in basal breast cancers, associated with poor prognosis and implicated in tumour ... -
Identification of protein interaction candidates for the GOLD domain of FYCO1
(Master thesis; Mastergradsoppgave, 2016-05-27)Autophagy is an evolutionary conserved degradative pathway, where damaged or surplus cytosolic components are sequestered into double membrane vesicles, autophagosomes, which become degraded through the lysosomal system. The autophagy is a dynamic process, which is depended of transport of autophagosomes along microtubule, to become degraded by lysosomes. One of the proteins involved in this transport ... -
Identification of surface proteins in a clinical Staphylococcus haemolyticus isolate by bacterial surface shaving
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-07)<p><i>Background - </i>The skin commensal <i>Staphylococcus haemolyticus</i> is an emerging nosocomial pathogen. Despite its clinical relevance, published information about <i>S. haemolyticus</i> virulence factors is scarce. In this study, the adhesive and biofilm forming properties of ten clinical and ten commensal <i>S. haemolyticus</i> strains were examined using standard adhesion and biofilm ... -
Identification of VIM-2-producing Pseudomonas aeruginosa from Tanzania is associated with sequence types 244 and 640 and the location of blaVIM-2 in a TniC integron
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Identification, isolation and characterisation of scavenging endothelial cells in placenta
(Master thesis; Mastergradsoppgave, 2014-05-15)Haemopoiesis occurs in the BM, where haemopoietic stem cells (HSC) reside in a three-dimensional “niche” and give rise to the millions of circulating blood cells required everyday of life. The precise regulation of this immense task occurs by interaction of HSC with other BM cells and extracellular matrix molecules. In addition, the BM vasculature has also now been identified as a key HSC regulator. ... -
Identification, molecular epidemiology, and antibiotic resistance characterization of Acinetobacter spp. clinical isolates
(Doctoral thesis; Doktorgradsavhandling, 2011-09-02) -
Identifisering av antistoffer mot blodplatespesifikke antigener ved hjelp av MAIPA-metode i en cohort av 196 gravide kvinner fra Egypt
(Master thesis; Mastergradsoppgave, 2007-10-01)Som del av blodplatenes cellemembran inngår et antall glykoproteiner som medierer blodplatenes celle-celle-interaksjoner. Blodplatespesifikke alloantigen (Human platelet antigen, HPA) kan føre til immunisering og dannelse av alloantistoffer når mennesker som selv ikke utrykker disse molekylene på overflaten av sine blodplater, blir eksponert for dem. Neonatal alloimmune trombocytopeni (NAIT) er en ... -
Identifisering av en gruppe glykosyltransferaser som mulige målgener for transkripsjonsfaktoren Pax6
(Master thesis; Mastergradsoppgave, 2009-11-09)Det har vært stadig mer forskning på rollen av glykosylering i utvikling av sykdommer i de siste tiårene. Glykosylering av proteiner er en prosess hvor karbohydrat grupper overføres til et protein ved hjelp av glykosyltransferaser. Denne prosessen er nødvendig for riktig folding av proteiner som gir riktig funksjon til ulike proteiner. Endringer i glykosylering av proteiner har vist å ha sammenheng ... -
Identifisering av PAX- og MMP-uttrykk i tre prostatakreft-cellelinjer
(Master thesis; Mastergradsoppgave, 2009-05-20)Invasjon og metastasering er den vanligste årsaken til død hos kreftpasienter og dermed et alvorlig klinisk problem. Det er derfor viktig å forske på dette området for å finne mekanismene bak disse prosessene. Matriks metalloproteinaser (MMPer) er overuttrykt i flere kreftformer. PAX6 er en transkripsjonsfaktor som er vist å regulere matriks metalloproteinase 2 og 9 (MMP-2 og MMP-9) i henholdsvis ... -
Identifisering og fenotyping av invariante NKT-celler
(Master thesis; Mastergradsoppgave, 2009-09-15)NKT-cellene utgjør en liten gruppe av det totale T-celleantall og uttrykker overflatemolekyler karakteristisk for både T- og NK-celler. De er aktive i en rekke ulike immunologiske funksjo-ner. Blant annet kan disse cellene produsere store mengder cytokiner, både pro- og antiin-flammatoriske, og de kan indusere celledød ved direkte cytolytisk aktivitet på andre celler som tumorceller og infiserte ... -
Identifying and correcting epigenetics measurements for systematic sources of variation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-21)<i>Background</i>: Methylation measures quantified by microarray techniques can be affected by systematic variation due to the technical processing of samples, which may compromise the accuracy of the measurement process and contribute to bias the estimate of the association under investigation. The quantification of the contribution of the systematic source of variation is challenging in datasets ... -
Identifying and measuring patient harms. A study of measuring adverse events in hospitalised patients by the Global Trigger Tool record review method
(Doctoral thesis; Doktorgradsavhandling, 2019-05-24)Patient harms, or adverse events which is the term used in this PhD thesis, is a global health problem. The Global Trigger Tool (GTT) is a widely used method to identify and measure adverse events (AEs). The method involves reviewers searching for triggers (situations) in randomly selected medical records and subsequently identifying AEs. However, the method is criticized due to the time used by ... -
Identifying and treating predictors of psychotic symptoms - How findings from Experience Sampling research can help to improve the treatment of psychosis and the prediction of relapse
(Doctoral thesis; Doktorgradsavhandling, 2021-06-10)The present thesis aims at using insights from ESM studies (i.e., frequent ecologically valid self-reports for approximately one week) to improve the treatment and the prediction psychotic symptoms. ESM indicates that warning signs, such as negative affect, worrying, sleep problems, or aberrant salience precede rapidly fluctuating psychotic symptoms throughout the day. Assuming underlying causal ...
