Blar i tittel Det helsevitenskapelige fakultet

Viser treff 4726-4745 av 10096

    • Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer 

      Nøst, Therese Haugdahl; Skogholt, Anne Heidi; Urbarova, Ilona Halva; Mjelle, Robin; Paulsen, Erna-Elise; Dønnem, Tom; Andersen, Sigve; Markaki, Maria; Røe, Oluf Dimitri; Johansson, Mikael; Johansson, Mattias; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood at LC diagnosis and evaluated, in pre-diagnostic blood specimens, how long before diagnosis expression changes of such candidate miRNAs could be detected. We identified upregulated ...

    • Increased risk of atrial fibrillation among elderly Norwegian men with a history of long-term endurance sport practice 

      Myrstad, Marius; Løchen, Maja-Lisa; Graff-Iversen, Sidsel; Gulsvik, Anne Kristine; Thelle, Dag Steinar; Stigum, Hein; Ranhoff, Anette Hylen (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-11-21)
      Atrial fibrillation (AF) is the most common cardiac arrhythmia. The prevalence increases with increasing age. In middle-aged men, endurance sport practice is associated with increased risk of AF but there are few studies among elderly people. The aim of this study was to investigate the role of long-term endurance sport practice as a risk factor for AF in elderly men. A crosssectional study ...

    • Increased risk of fatal paediatric injuries in rural Northern Norway 

      Holter, June Alette; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)
      <i>Background</i> - Finnmark, Northern Norway, had a mortality rate for paediatric injury in 1998‐2007 that was more than twice the national average. We investigated whether this rate had decreased in 2008‐2015 after improvements in emergency care. We also compared the mortality rate to rates of non‐fatal injury and trauma team activation both regionally and in Norway.<p> <p><i>Methods</i> - The ...

    • The increased risk of venous thromboembolism by advancing age cannot be attributed to the higher incidence of cancer in the elderly: the Tromsø study 

      Blix, Kristine; Brækkan, Sigrid Kufaas; Le Cessie, S.; Skjeldestad, Finn Egil; Cannegieter, Suzanne C.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Increased secondary/primary bile acid ratio in chronic heart failure 

      Mayerhofer, Christiane Caroline; Ueland, Thor; Broch, Kaspar; Vincent, Royce P.; Cross, Gemma F.; Dahl, Christen Peder; Aukrust, Pål; Gullestad, Lars; Hov, Johannes Espolin Roksund; Trøseid, Marius (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-09)
      <p><i>Objective</i> Bile acids (BAs) are now recognized as signaling molecules and emerging evidence suggests that BAs affect cardiovascular function. The gut microbiota has recently been linked to the severity of heart failure (HF), and microbial metabolism has a major impact on BA homeostasis. We aimed to investigate the pattern of BAs, and particularly microbiota-transformed (secondary) BAs, in ...

    • Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases 

      Kryeziu, Kushtrim; Moosavi, Seyed Hossein; Bergsland, Christian Holst; Guren, Marianne; Eide, Peter Andreas Wold; Totland, Max; Lassen, Kristoffer; Abildgaard, Andreas; Nesbakken, Arild; Sveen, Anita; Lothe, Ragnhild Adelheid (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-08)
      Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer. Patient-derived organoids (PDOs) may predict clinical drug responses ex vivo and ofer an opportunity to evaluate novel treatment strategies in a personalized fashion. Here we have evaluated spatio-temporal functional and molecular dynamics of fve PDO models ...

    • Increased sinusoidal flow is not the primary stimulus to liver regeneration 

      Conley, Lene N.; Mortensen, Kim Erlend; Nygaard, Ingvild; Sorenesen, Peter; Mortensen, Elin; Bendixen, Christian; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2010-01-20)
      Background: Hemodynamic changes in the liver remnant following partial hepatectomy (PHx) have been suggested to be a primary stimulus in triggering liver regeneration. We hypothesized that it is the increased sinusoidal flow per se and hence the shear-stress stimulus on the endothelial surface within the liver remnant which is the main stimulus to regeneration. In order to test this hypothesis we ...

    • Increased sinusoidal flow is not the primary stimulus to liver regeneration 

      Conley, LN; Mortensen, Kim Erlend; Nygård, Ingvild; Sørensen, Peter; Mortensen, Elin; Bendixen, C; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Increased Systemic and Local Interleukin 9 Levels in Patients with Carotid and Coronary Atherosclerosis 

      Gregersen, Ida; Skjelland, Mona; Holm, Sverre; Holven, Kirsten Bjørklund; Sørensen, Kirsten; Russell, David; Askevold, Erik Tandberg; Dahl, Christen Peder; Ørn, Stein; Gullestad, Lars; Mollnes, Tom Eirik; Ueland, Thor; Aukrust, Pål; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Objective: Atherosclerosis is a chronic inflammatory disorder that involves a range of inflammatory mediators. Although interleukin (IL)-9 has been related to inflammation, there are at present no data on its role in atherosclerosis. Here we have examined IL-9 and IL-9 receptor (IL-9R) systemically and locally in patients with coronary and carotid atherosclerosis. Methods: Plasma IL-9 was quantified ...

    • Increased thromboinflammatory load in hereditary angioedema 

      Gramstad, Olav Rogde; Schjalm, Camilla; Mollnes, Tom Eirik; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-10)
      C1 inhibitor (C1Inh) is a serine protease inhibitor involved in the kallikrein-kinin system, the complement system, the coagulation system, and the fibrinolytic system. In addition to the plasma leakage observed in hereditary angioedema (HAE), C1Inh deficiency may also affect these systems, which are important for thrombosis and inflammation. The aim of this study was to investigate the thromboinflammatory ...

    • Increasing access to cognitive screening in the elderly: Applying natural language processing methods to speech collected over the telephone 

      Diaz-Asper, Catherine; Chandler, Chelsea; Turner, Raymond S.; Reynolds, Brigid; Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-30)
      Barriers to healthcare access are widespread in elderly populations, with a major consequence that older people are not benefiting from the latest technologies to diagnose disease. Recent advances in the automated analysis of speech show promising results in the identification of cognitive decline associated with Alzheimer's disease (AD), as well as its purported pre-clinical stage. We utilized ...

    • Increasing mortality in schizophrenia: Are women at particular risk? A follow-up of 1111 patients admitted during 1980-2006 in Northern Norway 

      Høye, Anne; Jacobsen, Bjarne Koster; Hansen, Vidje (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      A study of mortality for all patients with schizophrenia admitted to the University Hospital of North Norway during 1980-2006 was performed, with a special focus on gender differences and changes in mortality during a period of transition from hospital-based to community-based care. A total of 1111 patients with schizophrenia were included, and the cohort was linked to the Causes of Death Register ...

    • Increasing physical activity efficiently: An experimental pilot study of a website and mobile phone intervention 

      Thorsteinsen, Kjærsti; Vittersø, Joar; Svendsen, Gunnvald Bendix (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      The main objective of this pilot study was to test the effectiveness of an online, interactive physical activity intervention that also incorporated gaming components. The intervention design included an activity planner, progress monitoring, and gamification components and used SMS text as a secondary delivery channel and feedback to improve engagement in the intervention content. Healthy adults ...

    • Increasing prevalence of myopia in Europe and the impact of education 

      Williams, Katie M.; Bertelsen, Geir; Cumberland, Phillippa; Wolfram, Christian; Verhoeven, Virginie J.M.; Anastasopoulos, Eleftherios; Buitendijk, Gabriëlle H.S.; Cougnard-Grégoire, Audrey; Creuzot-Garcher, Catherine; Erke, Maja Gran; Hogg, Ruth; Höhn, René; Hysi, Pirro; Khawaja, Anthony P.; Korobelnik, Jean-François; Ried, Janina; Vingerling, Johannes R.; Bron, Alain; Dartigues, Jean-François; Fletcher, Astrid; Hofman, Albert; Kuijpers, Robert W.A.M.; Luben, Robert N; Oxele, Konrad; Topouzis, Fotis; Hanno, Therese von; Mirshahi, Alireza; Foster, Paul J.; Van Duijn, Cornelia M.; Pfeiffer, Norbert; Delcourt, Cécile; Klaver, Caroline C.W.; Rahi, Jugnoo; Hammond, Christopher J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07)
      Purpose: To investigate whether myopia is becoming more common across Europe and explore whether increasing education levels, an important environmental risk factor for myopia, might explain any temporal trend. <p>Design: Meta-analysis of population-based, cross-sectional studies from the European Eye Epidemiology (E3 ) Consortium. <p>Participants: The E3 Consortium is a collaborative network ...

    • Increasing propensity to mind‐wander by transcranial direct current stimulation? A registered report 

      Boayue, Nya Mehnwolo; Csifcsak, Gabor; Aslaksen, Per M; Turi, Zsolt; Antal, Andrea; Groot, Josephine Maria; Hawkins, Guy E.; Forstmann, Birte U.; Opitz, Alexander; Thielscher, Axel; Mittner, Matthias (Journal article; Tidsskriftartikkel, 2019-01-24)
      Transcranial direct current stimulation (tDCS) has been proposed to be able to modulate different cognitive functions. However, recent meta‐analyses conclude that its efficacy is still in question. Recently, an increase in subjects’ propensity to mind‐wander has been reported as a consequence of anodal stimulation of the left dorsolateral prefrontal cortex (Axelrod et al., Proceedings of the National ...

    • The Incredible Years Parents and Babies Program: A Pilot Randomized Controlled Trial 

      Pontoppidan, Maiken; Klest, Sihu; Møller Sandoy, Tróndur (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Introduction Infancy is an important period of life; adverse experiences during this stage can have both immediate and lifelong impacts on the child’s mental health and well-being. This study evaluates the effects of offering the Incredible Years Parents and Babies (IYPB) program as a universal intervention. Method We conducted a pragmatic, two-arm, parallel pilot randomized controlled ...

    • The Incredible Years Teacher Classroom Management Programme in Kindergartens: Effects of a Universal Preventive Effort 

      Fossum, Sturla; Handegård, Bjørn Helge; Drugli, May Britt (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-21)
      The purpose of this study was to identify preventive effects of the Incredible Years (IY) teacher classroom management (TCM) programme, which is employed in Norwegian kindergartens for 3-year-old to 6-year-old children. IY TCM is a universal preventive intervention intended to reduce the frequency of inappropriate types of behaviour and support children’s social- and emotional competence in kindergartens ...

    • The independent and joint associations of physical activity and body mass index with myocardial infarction: The Tromsø Study 

      Renninger, Marius; Løchen, Maja-Lisa; Ekelund, Ulf; Hopstock, Laila Arnesdatter; Jørgensen, Lone; Mathiesen, Ellisiv B.; Njølstad, Inger; Schirmer, Henrik; Wilsgaard, Tom; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-13)
      Physical activity and overweight are associated with myocardial infarction (MI). However, their joint association with MI remains unclear. Our objective was to examine the independent and joint association between leisuretime physical activity (LTPA), body mass index (BMI) and MI. This prospective cohort study included 16,572 men and women (47.5% women) aged 20–54 years who took part in the second ...

    • Independent and Tissue-Specific Prognostic Impact of miR-126 in Nonsmall Cell Lung Cancer 

      Dønnem, Tom; Lønvik, Kenneth; Eklo, Katrine; Berg, Thomas; Sørbye, Sveinung Wergeland; Al-Shibli, Khalid Ibrahim; Al-Saad, Samer; Andersen, Sigve; Stenvold, Helge; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Angiogenesis is pivotal in tumor development. Vascular endothelial growth factor-A (VEGF-A) is considered one of the most important angiogenic factors, but lately several microRNAs (miRs) have been associated with vascular development. miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression ...

    • Independent External Validation of the METSSS Model Predicting Survival after Palliative Radiotherapy 

      Nieder, Carsten; Mannsåker, Bård; Yobuta, Rosalba (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-26)
      Background/Aim: A validation of the recently published METSSS model (developed from a large US database) predicting survival after palliative radiotherapy was performed. METSSS includes age, sex, cancer type, localization of distant metastases, comorbidity, and radiotherapy site. Patients and Methods: Both 1- and 5-year survival was assessed in the validation cohort. Deviations between model-predicted ...