Now showing items 610-629 of 5518

    • C-reactive protein and other circulating biomarkers in carotid atherosclerosis and cardiovascular disease. The Tromsø Study 1994-2013 

      Eltoft, Agnethe (Doctoral thesis; Doktorgradsavhandling, 2018-11-07)
      Hjerte- og karsykdom er ledende årsak til død og sykelighet på verdensbasis. I Norge er det årlig ca. 13 000 hjerteinfarkt og 12 000 hjerneslag. Til tross for at den forebyggende og akuttmedisinske behandlingen er betydelig forbedret i løpet av de siste 30 år, forventes en fortsatt økning i hjerte- og karsykdommer på verdensbasis. De tradisjonelle risikofaktorene (alder, kjønn, blodtrykk, kolesterol, ...
    • C-reactive protein and risk of venous thromboembolism: Results from a population-based case-crossover study 

      Grimnes, Gro; Isaksen, Trond; Tichelaar, Ynse Ieuwe Gerardus Vladimir; Brox, Jan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-19)
      Long-term, low-grade inflammation does not seem to be a risk factor for venous thromboembolism. The impact of acute inflammation, regardless of cause, on risk of venous thromboembolism is scarcely studied. We aimed to investigate the impact of acute inflammation, assessed by C-reactive protein, on short-term risk of venous thromboembolism. We conducted a case-crossover study of patients with venous ...
    • C-reactive protein point-of-care testing and antibiotic prescribing for acute respiratory tract infections in rural primary health centres of North Ethiopia: A cross-sectional study 

      Yebyo, Henock; Medhanyie, Araya Abrha; Spigt, Marcus; Hopstaken, Rogier (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-14)
      Unjustified antibiotic prescribing for acute upper respiratory infections (URTIs) is probably more common in poor-resource settings where physicians are scarce. Introducing C-reactive protein (CRP) point-of-care testing in such settings could reduce the misuse of antibiotics, which could avert antibiotic resistance. However, information useful for the applicability of CRP test in resource-limited ...
    • Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft 

      Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr Asbjørg; Borgos, Sven Even F.; Kildal, Wanja; Snipstad, Sofie; Sulheim, Einar; Fleten, Karianne Giller; Askautrud, Hanne Arenberg; Engebraaten, Olav; Flatmark, Kjersti; Iversen, Tore Geir; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-04)
      The effect of poly(2-ethyl-butyl cyanoacrylate) nanoparticles containing the cytotoxic drug cabazitaxel was studied in three breast cancer cell lines and one basal-like patient-derived xenograft model grown in the mammary fat pad of immunodeficient mice. Nanoparticle-encapsulated cabazitaxel had a much better efficacy than similar concentrations of free drug in the basal-like patient-derived xenograft ...
    • Caesarean section rates and activity-based funding in Northern Norway: A model-based study using the World Health Organization's recommendation 

      Norum, Jan; Svee, Tove Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-16)
      <i>Objective</i>: Caesarean section (CS) rates vary significantly worldwide. ,e World Health Organization (WHO) has recommended a maximum CS rate of 15%. Norwegian hospitals are paid per CS (activity-based funding), employing the diagnosis-related group (DRG) system. We aimed to document how financial incentives can be affected by reduced CS rates, according to the WHO’s recommendation. <p> <p> ...
    • Calanus oil and its lipid constituents - Impact on obesity and obesity-related metabolic disorders in rodents 

      Höper, Anje Christina (Doctoral thesis; Doktorgradsavhandling, 2014-02-26)
      Fedme er et økende helseproblem, og spesielt er avleiring av bukfett forbundet med økt risiko for en rekke sykdommer. Kosttilskudd med omega-3 fettsyrer har vist positive effekter på fedme-relaterte sykdommer. Calanusolje er et relativt nytt produkt som produseres fra raudåte (Calanus finmarchicus) som finnes i store mengder i norske farvann. Oljen har lavt innhold av miljøgifter og er rik på ...
    • Calculating the 30-day survival in acute myocardial infarction: should we use the treatment chain or the hospital catchment model? 

      Norum, Jan; Hansen, Tonya Moen; Hovland, Anders; Balteskard, Lise; Haug, Bjørn; Olsen, Frank; Trovik, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-12)
      <p><i>Introduction</i> Acute myocardial infarction (AMI) is a potentially deadly disease and significant efforts have been concentrated on improving hospital performance. A 30-day survival rate has become a key quality of care indicator. In Northern Norway, some patients undergoing AMI are directly transferred to the Regional Cardiac Intervention Center at the University Hospital of North Norway ...
    • A Call for Urgent Monitoring of Food and Water Security Based on Relevant Indicators for the Arctic 

      Nilsson, Lena Maria; Destouni, Georgia; Berner, James; Dudarev, Alexy A.; Mulvad, Gert; Odland, Jon Øyvind; Parkinson, Alan; Tikhonov, Constantine; Rautio, Arja; Evengård, Birgitta (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      This perspective paper argues for an urgent need to monitor a set of 12 concrete, measurable indicators of food and water security in the Arctic over time. Such a quantitative indicator approach may be viewed as representing a reductionist rather than a holistic perspective, but is nevertheless necessary for actually knowing what reality aspects to monitor in order to accurately understand, quantify, ...
    • Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? 

      Sørbye, Sveinung; Pedersen, Mette Kristin; Ekeberg, Bente; Wiliams, Merete E. Johansen; Sauer, Torill; Chen, Ying (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-22)
      Background: The Norwegian Cervical Cancer Screening Program recommends screening every 3 years for women between 25 and 69 years of age. There is a large difference in the percentage of unsatisfactory samples between laboratories that use different brands of liquid-based cytology. We wished to examine if inadequate ThinPrep samples could be satisfactory by processing them with the SurePath ...
    • Can Auditory Brainstem Response be Used as a Diagnostic Tool for Patients Suffering from Schizophrenia, Attention Deficit Hyperactivity Disorder, and Bipolar Disorder? 

      Wahlström, Viktor; Åhlander, Fredrik; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-12)
      <p>Background: Psychiatric disorders, such as schizophrenia, attention deficit hyperactivity disorder (ADHD), and bipolar disorder, may sometimes be difficult to diagnose. There is a great need for a valid and reliable diagnostic tool to aid clinicians in arriving at the diagnoses in a timely and accurate manner. Prior studies have suggested that patients suffering from schizophrenia and ADHD may ...
    • Can current prognostic scores reliably guide treatment decisions in patients with brain metastases from malignant melanoma? 

      Nieder, Carsten; Marienhagen, Kirsten; Geinitz, Hans; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      We evaluated the performance of the new 4-tiered melanoma-specific graded prognostic assessment (GPA) score and the previously published general GPA score in patients with brain metastases from malignant melanoma managed with different approaches including best supportive care. Materials and Methods: Retrospective analysis of 51 patients. Compared with the original analysis of the melanoma-specific ...
    • Can drug-related information reverse the effects of a local anesthetic cream? An investigation into the nocebo hyperalgesic response 

      Zwarg, Maria Lorentze; Hage Eilertsen, Hans-Ingvald (Master thesis; Mastergradsoppgave, 2013-04-30)
      Objective: Verbal information accompanying administration of a drug has been shown to modulate treatment outcome, in both positive and negative directions. If drug effects alter as a function of verbal suggestions, negative information may potentially abolish or even reverse treatment effects. To test whether nocebo information can reverse the effect of a drug, we investigated how such information ...
    • Can environmental laws fulfill their promise? Stories from Canada 

      Bankes, Nigel; Mascher, Sharon; Olszynski, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Can nanomedicine improve the semen quality? The potentials of liposomal curcumin. 

      Wu, Iren Yeeling (Master thesis; Mastergradsoppgave, 2015-05-13)
      INTRODUCTION: Worldwide, 10-15 % couples are infertile, and 50 % of the couples seeking assisted reproductive techniques do so because of defective sperm quality. The semen quality can be directly linked to oxidative stress (OS). Due to high metabolic rates and weak anti-oxidant systems, sperm cells are unable to defend against OS produced exogenously and endogenously. Vitamin C and/or vitamin E are ...
    • Can oxytocin augmentation modify the risk of epidural analgesia by maternal age in cesarean sections? 

      Rossen, Janne; Klungsøyr, Kari; Albrechtsen, Susanne; Løkkegård, Ellen; Rasmussen, Steen; Bergholt, Thomas; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-07)
      <p><i>Introduction</i>: Maternal age is an established risk factor for cesarean section; epidural analgesia and oxytocin augmentation may modify this association. We investigated the effects and interactions of oxytocin augmentation, epidural analgesia and maternal age on the risk of cesarean section.</p> <p><i>Material and methods</i>: In all, 416 386 nulliparous women with spontaneous onset of ...
    • Can structural indicators explain gender difference in life expectancy (LE) at birth among WHO member countries? 

      Bye, Stefan (Master thesis; Mastergradsoppgave, 2012-06)
      Forskjellen i life expectancy at birth mellom kjønn varierer fra land til land og i de fleste tilfellene så lever kvinner lengre enn menn. Det globale gjennomsnittet er på ca 7% lengre levetid for kvinner enn menn, men man har forskjeller som er helt opp i 23%. Det finnes etablerte hypoteser på hvorfor kvinner lever lengre enn menn og i denne oppgaven vil jeg se på hvordan sosiale og strukturelle ...
    • Can the health related quality of life measure QOLIBRI- overall scale (OS) be of use after stroke? A validation study 

      Heiberg, Guri Anita; Pedersen, Synne Garder; Friborg, Oddgeir; Nielsen, Jørgen Feldbæk; Holm, Henriette Stabel; von Steinbüchel, Nicole; Arntzen, Cathrine; Anke, Audny (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      <i><p>Background</i>: Brief measures of health-related quality of life (HRQOL) that assess both patient-reported functioning and well-being after stroke are scarce. The objective of this study was to examine reliability and validity of one of these measures, the patient-reported Quality of Life after Brain Injury–Overall Scale (QOLIBRI-OS), in patients after stroke.</p> <i><p>Methods</i>: Stroke ...
    • Can video mobile phones improve CPR quality when used for dispatcher assistance during simulated cardiac arrest? 

      Bolle, Stein Roald; Gilbert, Mads; Scholl, Jeremiah (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)
      Background: Because mobile telephones may support video calls, emergency medical dispatchers may now connect visually with bystanders during pre-hospital cardiopulmonary resuscitation (CPR). We studied the quality of simulated dispatcher-assisted CPR when guidance was delivered to rescuers by video calls or audio calls from mobile phones. Methods: One hundred and eighty high school students were ...
    • Can vitamin D-3 supplementation prevent bone loss in persons with MS? A placebo-controlled trial 

      Steffensen, Linn Hofsøy; Jørgensen, Lone; Straume, Bjørn; Mellgren, Svein Ivar; Kampman, Margitta Theodora (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Multiple sclerosis (MS) is a possible cause of secondary osteoporosis. In this phase II trial we assessed whether a weekly dose of 20,000 IU vitamin D3 prevents bone loss in ambulatory persons with MS age 18–50 years. ClinicalTrials.gov ID NCT00785473. All patients managed at the University Hospital of North Norway who fulfilled the main inclusion criteria were invited to participate in this ...