Immunoregulatory protein B7-H3 is involved in the oncogenic and metastatic potential of cancer cells, as well as in drug resistance. Resistance to conventional chemotherapy is an important aspect of melanoma treatment, and a better understanding of how B7-H3 enhances drug resistance may lead to the development of more effective therapies. We investigated the <i>in vitro</i> and <i>in vivo</i> ...

The selective autophagy receptor p62/sequestosome 1 (SQSTM1) interacts directly with LC3 and is involved in oxidative stress signaling in two ways in mammals. First, p62 is transcriptionally induced upon oxidative stress by the NF-E2-related factor 2 (NRF2) by direct binding to an antioxidant response element in the p62 promoter. Second, p62 accumulation, occurring when autophagy is impaired, leads ...

<i>Background</i>: Cross-country skiing (XCS) racing, a popular international winter sport, is complex and challenging from physical, technical, and tactical perspectives. Despite the vast amount of research focusing on this sport, no review has yet addressed the pacing strategies of elite XCS racers or the factors that influence their performance. The aim was to review the scientific literature ...

Bakgrunn: Løpsutviklingen som utholdenhetsidretter har stor innflytelse på prestasjonen. Selv om flere studier har undersøkt løpsutvikling i flere idretter, er det lite informasjon om løpsutviklingen til langdistanse langrennsløpere, og for begge kjønn. Denne masteroppgaven undersøker hva slags løpsutviklingen utøverne adapterer i et langdistanseløp, og om ulike terreng vil påvirke deres løpsutvikling. ...

A cohort of 89 healthy children was recruited from Tromsø during 2009. All children had a radiograph and an MRI of the left wrist, while 74 met for a follow-up study during 2013. The initial examination showed that all children had numerous bony depressions in one or more of the carpal bones, and that these depressions could mimic erosions as defined in the adult rheumatoid arthritis literature, and ...

Objectives<br> Although pain is a significant symptom in chronic fatigue syndrome (CFS), pain is poorly understood in adolescents with CFS. The aim of this study was to explore pain distribution and prevalence, pain intensity and its functional interference in everyday life, as well as pressure pain thresholds (PPT) in adolescents with CFS and compare this with a control group of healthy adolescents ...

<i>Background</i>: Previous studies shows that elite and high-level athletes possess consistently higher pain tolerance to ischemic and cold pain stimulation compared to recreationally active. However, the data previously obtained within this field is sparse and with low consistency.<p><p> <i>Purpose</i>: The aim of the present study was to examine the difference in pain perception between elite ...

<b>Background</b> Unrecognized myocardial infarction (MI) is a prevalent condition associated with a similar risk of death as recognized MI. It is unknown why some persons experience MI with few or no symptoms; however, one possible explanation is attenuated pain sensitivity. To our knowledge, no previous study has examined the association between pain sensitivity and recognition of MI. <b>Methods ...

<p><i>Context - </i>Clinical trials have demonstrated the efficacy and safety of the capsaicin 8% patch in patients with peripheral neuropathic pain (PNP); however, few studies have assessed this treatment in a clinical practice. <p><i>Objective - </i>To determine whether treatment and re‐treatment with the capsaicin 8% patch reduce PNP intensity in clinical practice. <p><i>Methods - </i>Three ...

Bakgrunn: Denne studien handler om palliativ omsorg til kreftpasienter i kommuner i Finnmark. Samhandlingsreformen legger føringer for at kommunene skal ha ansvar for behandlingen av pasientene i egen kommune. Infrastrukturen i Finnmark, både når det gjelder klima, reisevei til sykehus, og tilgang til fagsykepleiere, gir særskilte utfordringer. Hensikten med denne studien var å få mer kunnskap om ...