Now showing items 3684-3703 of 5456

    • p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance 

      Flem-Karlsen, Karine; Tekle, Christina; Øyjord, Tove Ragnhild; Flørenes, Vivi Ann; Mælandsmo, Gunhild Mari; Fodstad, Øystein; Nunes-Xavier, Caroline Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-09)
      Immunoregulatory protein B7-H3 is involved in the oncogenic and metastatic potential of cancer cells, as well as in drug resistance. Resistance to conventional chemotherapy is an important aspect of melanoma treatment, and a better understanding of how B7-H3 enhances drug resistance may lead to the development of more effective therapies. We investigated the <i>in vitro</i> and <i>in vivo</i> ...
    • Pacemaker implantation in small hospitals : complication rates comparable to larger centres 

      Haug, Bjørn; Kjelsberg, Kjærsti; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Some countries have a demography that makes it necessary to maintain relatively small pacemaker centres. We wanted to assess the quality of pacemaker surgery in two such hospitals. Through patient records we gathered information on ∼535 consecutive primary pacemaker implantations in two small pacemaker centres with 30 and 80 annual operations, respectively. All patients were followed for 3 years. ...
    • Pacing and predictors of performance during cross-country skiing races: A systematic review 

      Stöggl, Thomas; Pellegrini, Barbara; Holmberg, Hans-Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-15)
      <i>Background</i>: Cross-country skiing (XCS) racing, a popular international winter sport, is complex and challenging from physical, technical, and tactical perspectives. Despite the vast amount of research focusing on this sport, no review has yet addressed the pacing strategies of elite XCS racers or the factors that influence their performance. The aim was to review the scientific literature ...
    • The pacing strategy and technique of male cross-country skiers With different levels of performance during a 15-km classical race 

      Welde, Boye; Stöggl, Thomas; Mathisen, Gunnar; Supej, Matej; Zoppirolli, Chiara; Winther, Andreas Kjæreng; Pellegrini, Barbara; Holmberg, Hans-Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-08)
      In this study the pacing strategy, cycle characteristics and choice of technique of elite male cross-country (XC) skiers during a three-lap, 15-km classical race with interval start were measured. During the Norwegian Championships in 2016, fast (n = 18, age: 26±4 yr; height: 182±4 cm; body mass: 78±3 kg (means±SD)) and slow skiers (n = 18, age: 22±2 yr; height: 183±5 cm; body mass: 78±6 kg) were ...
    • Pacing Strategy in Long Distance Cross-Country Skiing. A study looking at female and male cross-country skiers at different performance level and how the track topography may influence their pacing strategy. 

      Bjørkesett, Eva (Master thesis; Mastergradsoppgave, 2019-05-14)
      Bakgrunn: Løpsutviklingen som utholdenhetsidretter har stor innflytelse på prestasjonen. Selv om flere studier har undersøkt løpsutvikling i flere idretter, er det lite informasjon om løpsutviklingen til langdistanse langrennsløpere, og for begge kjønn. Denne masteroppgaven undersøker hva slags løpsutviklingen utøverne adapterer i et langdistanseløp, og om ulike terreng vil påvirke deres løpsutvikling. ...
    • Paediatric dentistry under general anaesthesia : from a patient perspective 

      Hammervold, Mari Katrine; Olsen, Karianne (Master thesis; Mastergradsoppgave, 2012-05-29)
      Introduction: The importance of good oral health in children is well documented. Extensive caries in young children has an impact on both oral and general health, including quality of life. It is important to offer DGA for patients where other options are not sufficient. Preventive measures can in many cases be done to reduce the number of DGA needed, and behaviour shaping techniques for all children ...
    • The Paediatric Wrist; Normal Age Related appearances on Magnetic Resonance Imaging and Radiographs. Follow up of a Healthy Cohort 

      Avenarius, Derk (Doctoral thesis; Doktorgradsavhandling, 2017-09-27)
      A cohort of 89 healthy children was recruited from Tromsø during 2009. All children had a radiograph and an MRI of the left wrist, while 74 met for a follow-up study during 2013. The initial examination showed that all children had numerous bony depressions in one or more of the carpal bones, and that these depressions could mimic erosions as defined in the adult rheumatoid arthritis literature, and ...
    • PAI-1 and t-PA/PAI-1 complex potential markers of fibrinolytic bleeding after cardiac surgery employing cardiopulmonary bypass. 

      Ozolina, A.; Strike, E.; Jaunalksne, I.; Krumina, A.; Bjertnæs, Lars J.; Vanags, I. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Enhanced bleeding remains a serious problem after cardiac surgery, and fibrinolysis is often involved. We speculate that lower plasma concentrations of plasminogen activator inhibitor – 1 (PAI-1) preoperatively and tissue plasminogen activator/PAI-1 (t-PA/PAI-1) complex postoperatively might predispose for enhanced fibrinolysis and increased postoperative bleeding. Totally 88 adult patients (mean ...
    • Pain and pressure pain thresholds in adolescents With chronic fatigue syndrome and healthy Controls: a cross-sectional study 

      Winger, Anette; Kvarstein, Gunnvald; Wyller, Vegard Bruun; Sulheim, Dag; Fagermoen, Frode Even; Småstuen, Milada Cvancarova; Helseth, Sølvi (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-10-06)
      Objectives<br> Although pain is a significant symptom in chronic fatigue syndrome (CFS), pain is poorly understood in adolescents with CFS. The aim of this study was to explore pain distribution and prevalence, pain intensity and its functional interference in everyday life, as well as pressure pain thresholds (PPT) in adolescents with CFS and compare this with a control group of healthy adolescents ...
    • Pain tolerance in persons with recognized and unrecognized myocardial infarction: a population-based, cross-sectional study 

      Øhrn, Andrea Sofie Henriette Milde; Nielsen, Christopher Sivert; Schirmer, Henrik; Stubhaug, Audun; Wilsgaard, Tom; Lindekleiv, Haakon (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-21)
      <b>Background</b> Unrecognized myocardial infarction (MI) is a prevalent condition associated with a similar risk of death as recognized MI. It is unknown why some persons experience MI with few or no symptoms; however, one possible explanation is attenuated pain sensitivity. To our knowledge, no previous study has examined the association between pain sensitivity and recognition of MI. <b>Methods ...
    • Pain-relieving effectiveness, quality of life and tolerability of repeated capsaicin 8% patch treatment of peripheral neuropathic pain in Scandinavian clinical practice 

      Hansson, Per; Jensen, Troels Staehelin; Kvarstein, Gunnvald; Strömberg, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-01)
      <p><i>Context - </i>Clinical trials have demonstrated the efficacy and safety of the capsaicin 8% patch in patients with peripheral neuropathic pain (PNP); however, few studies have assessed this treatment in a clinical practice. <p><i>Objective - </i>To determine whether treatment and re‐treatment with the capsaicin 8% patch reduce PNP intensity in clinical practice. <p><i>Methods - </i>Three ...
    • Palliativ behandling i en nordnorsk utkantkommune: Hva skal til for å lykkes? 

      Brøndbo, Birgit (Master thesis; Mastergradsoppgave, 2015-05-28)
      Resymé Formål: Hensikten med denne oppgaven har vært å utforske hva som kan være vesentlige faktorer for å etablere og opprettholde et velfungerende, tverrfaglig palliativt tilbud i kommunal regi. Dette er et aktuelt tema når norske kommuner de kommende årene møter store utfordringer i forhold til palliativ omsorg – både fordi befolkningen blir eldre og fordi Samhandlingsreformen stiller nye krav. ...
    • Palliativ omsorg til kreftpasienter i kommunehelsetjenesten. «Hvilke utfordringer møter sykepleierne i små kommuner i Finnmark, i ytelsen av palliativ omsorg til kreftpasienter, og hvordan forholder de seg til disse utfordringene?» 

      Edvardsen, Trine Lise (Master thesis; Mastergradsoppgave, 2016-05-11)
      Bakgrunn: Denne studien handler om palliativ omsorg til kreftpasienter i kommuner i Finnmark. Samhandlingsreformen legger føringer for at kommunene skal ha ansvar for behandlingen av pasientene i egen kommune. Infrastrukturen i Finnmark, både når det gjelder klima, reisevei til sykehus, og tilgang til fagsykepleiere, gir særskilte utfordringer. Hensikten med denne studien var å få mer kunnskap om ...
    • The Palliative Radiotherapy and Inflammation Study (PRAIS) - Protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain 11 Medical and Health Sciences 1103 Clinical Sciences 

      Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Abramova, Tatiana Mikhailovna; Baas, Theo; Mørkeset, Siri Tessem; Caraceni, Augusto; Laird, Barry J; Boland, Jason W.; Rossi, Romina; Garcia-Alonso, Elena; Stensheim, Hanne; Loge, Jon Håvard; Hjermstad, Marianne Jensen; Bjerkeset, Ellen; Bye, Asta; Lund, Jo-Åsmund; Solheim, Tora Skeidsvoll; Vagnildhaug, Ola Magne; Brunelli, Cinzia; Damås, Jan Kristian; Mollnes, Tom Eirik; Kaasa, Stein; Klepstad, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-28)
      <i><p>Background</i>: Radiation therapy (RT) results in pain relief for about 6 of 10 patients with cancer induced bone pain (CIBP) caused by bone metastases. The high number of non-responders, the long median time from RT to pain response and the risk of adverse effects, makes it important to determine predictors of treatment response. Clinical features such as cancer type, performance status and ...
    • Palliative radiotherapy with or without additional care by a multidisciplinary palliative care team in patients with newly diagnosed cancer: A retrospective matched pairs comparison 

      Nieder, Carsten; Dalhaug, Astrid; Pawinski, Adam; Haukland, Ellinor; Mannsåker, Bård; Engljähringer, Kirsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-07)
      Purpose: To analyze survival after early palliative radiotherapy (RT) in patients managed exclusively by regular oncology staff or a multidisciplinary palliative care team (MPCT) in addition. <p>Methods: Retrospective matched pairs analysis. Comparison of two groups of 29 patients each: MPCT versus none. Early RT started within three months after cancer diagnosis. <p>Results: Bone and brain ...
    • Palliative Radiotherapy with or without Additional Care by a Multidisciplinary Palliative Care Team: A Retrospective Comparison 

      Nieder, Carsten; Angelo, Kent; Dalhaug, Astrid; Pawinski, Adam; Aandahl, Gro; Haukland, Ellinor; Engljähringer, Kirsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Palliative RT Score 

      Angelo, Kent (Master thesis; Mastergradsoppgave, 2013-06-02)
      Purpose To develop predictive models that allow for reduced overutilization of palliative radiotherapy (PRT) during the final 30 days of life in patients with incurable cancer. Patients and Methods Uni- and multivariate analyses of factors predicting PRT during the final 30 days of life for all PRT courses administered at a dedicated PRT facility between 20.06.07 and 31.12.2009. Development ...
    • A parameter for IL-10 and TGF-β mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers 

      Lind, Andreas; Brekke, Kristin; Pettersen, Frank Olav; Mollnes, Tom Eirik; Trøseid, Marius; Kvale, Dag (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men : a cross-sectional study 

      Hjelmesæth, Jøran; Hofsø, Dag; Aasheim, Erlend T.; Jenssen, Trond Geir; Moan, Johan; Hager, Helle; Røislien, Jo; Bollerslev, Jens (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-02-03)
      Background: The prevalence of vitamin D insufficiency and secondary hyperparathyroidism is high among morbidly obese subjects. Further, low serum levels of 25-hydroxyvitamin D (25 [OH]D) and magnesium have been associated with increased risk of the metabolic syndrome (MS), and recently, a possible link between PTH and MS has been reported. Although it is well known that the synthesis and secretion ...
    • Parent participation in alcohol prevention: Evaluation of an alcohol prevention programme 

      Adolfsen, Frode; Strøm, Henriette Kyrrestad; Martinussen, Monica; Handegård, Bjørn Helge; Natvig, Henrik; Eisemann, Martin; Koposov, Roman A (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-25)
      Aim: <br>The main purpose of this study was to evaluate the effectiveness of the parental part of the Norwegian Unge & Rus (Youth and Alcohol) programme. The intervention was aimed at changing parents’ rules and attitudes towards adolescent alcohol use, and their ability to talk with their adolescents about alcohol, as well as improving parents’ relationships with and knowledge about their ...