Now showing items 4706-4725 of 6105

    • Race/ethnic differences in the associations of the Framingham risk factors with carotid IMT and cardiovascular events 

      Gijsberts, Crystel M.; Groenewegen, Karlijn A.; Hoefer, Imo E.; Eijkemans, Marinus J.C.; Asselbergs, Folkert W.; Anderson, Todd J.; Britton, Annie R.; Dekker, Jacqueline M.; Engström, Gunnar; Evans, Greg W.; de Graaf, Jacqueline; Grobbee, Diederick E.; Hedblad, Bo; Holewijn, Suzanne; Ikeda, Ai; Kitagawa, Kazuo; Kitamura, Akihiko; De Kleijn, Dominique P.V.; Lonn, Eva M.; Lorenz, Matthias W.; Mathiesen, Ellisiv B.; Nijpels, Giel; Okazaki, Shuhei; O'Leary, Daniel H.; Pasterkamp, Gerard; Peters, Sanne A.E.; Polak, Joseph F.; Price, Jacqueline F.; Rembold, Christopher M.; Rosvall, Maria; Rundek, Tatjana; Salonen, Jukka T.; Sitzer, Matthias; Stehouwer, Coen D.A.; Bots, Michiel L.; Den Ruijter, Hester M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-02)
      Background Clinical manifestations and outcomes of atherosclerotic disease differ between ethnic groups. In addition, the prevalence of risk factors is substantially different. Primary prevention programs are based on data derived from almost exclusively White people. We investigated how race/ethnic differences modify the associations of established risk factors with atherosclerosis and ...
    • Racial Variation in Echocardiographic Reference Ranges for Left Chamber Dimensions in Children and Adolescents: A Systematic Review 

      Majonga, Edith D.; Norrish, Gabrielle; Rehman, Andrea M.; Kranzer, Katharina; Mujuru, Hilda A.; Nathoo, Kusum; Odland, Jon Øyvind; Kaski, Juan P.; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-04)
      Abstract Echocardiography plays a critical role in the assessment of cardiac disease. Important differences in echocardiographically derived cardiac chamber dimensions have been previously highlighted in different population groups in adult studies, but this has not been systematically studied in children, whose body size changes throughout childhood. The aim of this study was to review the ...
    • Radiation-Induced Transformation of Immunoregulatory Networks in the Tumor Stroma 

      Martinez, Inigo Zubiavrre; Chalmers, Anthony J.; Hellevik, Turid (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-26)
      The implementation of novel cancer immunotherapies in the form of immune checkpoint blockers represents a major advancement in the treatment of cancer, and has renewed enthusiasm for identifying new ways to induce antitumor immune responses in patients. Despite the proven efficacy of neutralizing antibodies that target immune checkpoints in some refractory cancers, many patients do not experience ...
    • Radiofrekvensablasjon av supraventrikulære takykardier ved UNN i perioden 2004 - 2006. 

      Eriksen, Amund Henrik (Master thesis; Mastergradsoppgave, 2008-09-15)
      Resymé Introduksjon: Radiofrekvensablasjon har blitt brukt som behandling mot supraventrikulære takykardier ved UNN siden 2004. Metoden går ut på at man via katetre plassert intrakardielt kartlegger utløsende fokus og/eller ledningsbaner som bidrar til å opprettholde arytmien. Ved å applisere radiofrekvensenergi over de ønskede områder kan man destruere substratet for arytmien. Jeg har gått gjennom ...
    • Radiografens individualisering av CT-kontrast undersøkelser 

      Nysted, Henning Joachim (Master thesis; Mastergradsoppgave, 2013-05-14)
      Prosjektets utgangspunkt er økningen i bruk av medisinsk røntgenundersøkelser i moderne tid, og da spesielt CT modaliteten. Det er en klar sammenheng mellom økt bruk av ioniserende stråling og økning av kreftinsidens, og nyere studier har vist at særlig CT modaliteten har bidratt stort til økningen. CT undersøkelser kombineres ofte med intravenøse kontrastmidler for å skape bildeserier med høy ...
    • Radiosynthesis and biological investigation of a novel fluorine-18 labeled benzoimidazotriazine- based radioligand for the imaging of phosphodiesterase 2A with positron emission tomography 

      Ritawidya, Rien; Wenzel, Barbara; Teodoro, Rodrigo; Toussaint, Magali; Kranz, Mathias; Deuther-Conrad, Winnie; Dukić-Stefanović, Sladjana; Ludwig, Friedrich-Alexander; Scheunemann, Matthias; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-15)
      A specific radioligand for the imaging of cyclic nucleotide phosphodiesterase 2A (PDE2A) via positron emission tomography (PET) would be helpful for research on the physiology and disease-related changes in the expression of this enzyme in the brain. In this report, the radiosynthesis of a novel PDE2A radioligand and the subsequent biological evaluation were described. Our prospective compound ...
    • Radiotherapy and the tumor stroma: the importance of dose and fractionation 

      Hellevik, Turid; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Ionizing radiation (IR) is a non-specific but highly effective way to kill malignant cells. However, tumor recurrence sustained by a minor fraction of surviving tumor cells is a commonplace phenomenon caused by the activation of both cancer cell intrinsic resistance mechanisms, and also extrinsic intermediaries of therapy resistance, represented by non-malignant cells and structural components of ...
    • A randomised clinical trial on the impact of early intervention on parental child-rearing attitudes and cognitive, motor and behavioral outcomes in preterm infants. 

      Nordhov, Solveig Marianne (Doctoral thesis; Doktorgradsavhandling, 2011-09-23)
      BACKGROUND: Preterm infants are at increased risk of cognitive problems/delay and behavioual problems in the long term. Studies have shown that their mothers are more overprotective, and find it hard to implement a nurturant child rearing practice compared to parents of term infants. To improve the parent-infant interaction and thereby influence infant development in a beneficial different early ...
    • Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: The Nordic-Baltic Bifurcation Study IV 

      Kumsars, Indulis; Holm, Niels Ramsing; Niemelä, Matti; Erglis, Andrejs; Kervinen, Kari; Christiansen, Evald Høj; Maeng, Michael; Dombrovskis, Andis; Abraitis, Vytautas; Kibarskis, Aleksandras; Trovik, Thor; Latkovskis, Gustavs; Sondore, Dace; Narbute, Inga; Terkelsen, Christian Juhl; Eskola, Markku; Romppanen, Hannu; Laine, Mika; Jensen, Lisette Okkels; Pietila, Mikko; Gunnes, Pål; Hebsgaard, Lasse; Frobert, Ole; Calais, Fredrik; Hartikainen, Juha; Aarøe, Jens; Ravkilde, Jan; Engstrøm, Thomas; Steigen, Terje; Thuesen, Leif; Lassen, Jens F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-19)
      <p><i>Background - </i>It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation. <p><i>Methods ...
    • A randomised placebo-controlled trial examining the effect on hand supination after the addition of a suprascapular nerve block to infraclavicular brachial plexus blockade 

      Flohr-Madsen, Sandra; Ytrebø, Lars Marius; Valen, Katrin; Wilsgaard, Tom; Klaastad, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-11)
      Some surgeons believe that infraclavicular brachial plexus blocks tends to result in supination of the hand/forearm, which may make surgical access to the dorsum of the hand more difficult. We hypothesised that this supination may be reduced by the addition of a suprascapular nerve block. In a double‐blind, randomised, placebo‐controlled study, our primary outcome measure was the amount of supination ...
    • A randomized controlled trial comparing self-referral to inpatient treatment and treatment as usual in patients with severe mental disorders 

      Sigrunarson, Vidir; Moljord, Inger Elise Opheim; Steinsbekk, Aslak; Eriksen, Lasse; Morken, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      <b>Background:</b> There has been a call for increased patient autonomy and participation in psychiatry. Some Community Mental Health Centers (CMHC) have implemented services called “self-referral to inpatient treatment” (SRIT) for patients with severe mental disorders.<br> <b>Aims:</b> To investigate whether SRIT could yield better outcomes after 12 months in use of mental health services ...
    • A randomized controlled trial of a six-session cognitive behavioral treatment of emotional disorders in adolescents 14–17 years old in child and adolescent mental health services (CAMHS) 

      Lorentzen, Veronica; Fagermo, Kenneth; Handegård, Bjørn Helge; Skre, Ingunn; Neumer, Simon-Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-14)
      <i>Background</i> - This study aims to investigate effectiveness of a 6-week, transdiagnostic cognitive behavioral therapy (CBT) for anxiety and depression in adolescents, the Structured Material for Therapy (SMART), in naturalistic settings of child and adolescent mental health outpatient services (CAMHS).<p><p> <i>Methods</i> - A randomized controlled trial with waiting list control (WLC) was ...
    • A randomized controlled trial on a smartphone self-help application (Be Good to Yourself) to reduce depressive symptoms 

      Lüdtke, Thies; Pult, Lilian Klara; Schröder, Johanna; Moritz, Steffen; Bücker, Lara (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-29)
      Depressive symptoms are common, yet only a subgroup of individuals receive adequate treatment. To reduce the treatment gap, several online self-help programs have been developed, yielding small to moderate effects. We developed a smartphone self-help application addressing depressive symptoms. We sought to evaluate its feasibility and efficacy in participants reporting a subjective need for help (a ...
    • Randomized phase II trial comparing twice daily hyperfractionated with once daily hypofractionated thoracic radiotherapy in limited disease small cell lung cancer 

      Grønberg, Bjørn Henning; Halvorsen, Tarje Onsøien; Fløtten, Øystein; Brustugun, Odd Terje; Brunsvig, Paal Fr.; Aasebø, Ulf; Bremnes, Roy M.; Tollåli, Terje; Hornslien, Kjersti; Aksnessæther, Bjørg Y.; Liaaen, Erik Dyb; Sundstrøm, Stein Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-23)
      <br>BACKGROUND: <br> Concurrent chemotherapy and thoracic radiotherapy (TRT) is recommended for limited disease small cell lung cancer (LD SCLC). Twice daily TRT is well documented, but not universally implemented - probably mainly due to inconvenience and concerns about toxicity. A schedule of three-week hypofractionated TRT is a commonly used alternative. This is the first randomized trial ...
    • Randomized trial of a novel game-based appointment system for a university hospital venereology unit: Study protocol 

      Gabarron, Elia; Serrano, Artur; Fernandez Luque, Luis; Wynn, Rolf; Schopf, Thomas Roger Griesbeck (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-08)
      <p>Background: Chlamydia is the most common reportable sexually transmitted disease (STD) in Norway, and its incidence in the two northernmost counties has been disclosed to be nearly the double of the Norwegian average. The latest publicly available rates showed that 85.6% of the new cases were diagnosed in people under 29 years old. The information and communication technologies are among the ...
    • Randomized trial of a novel game-based appointment system for a university hospital venereology unit: Study protocol 

      Gabarron, Elia; Fernandez-Luque, Luis; Serrano, Artur; Wynn, Rolf; Schopf, Thomas Roger Griesbeck (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-08)
      Background: Chlamydia is the most common reportable sexually transmitted disease (STD) in Norway, and its incidence in the two northernmost counties has been disclosed to be nearly the double of the Norwegian average. The latest publicly available rates showed that 85.6% of the new cases were diagnosed in people under 29 years old. The information and communication technologies are among the most ...
    • A randomized trial of telemedicine efficacy and safety for nonacute headaches 

      Müller, Kai Ivar; Alstadhaug, Karl Bjørnar; Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-11)
      <p><i>Objective</i>: To evaluate long-term treatment efficacy and safety of one-time telemedicine consultations for nonacute headaches.</p> <p><i>Methods</i>: We randomized, allocated, and consulted nonacute headache patients via telemedicine (n = 200) or in a traditional manner (n = 202) in a noninferiority trial. Efficacy endpoints, assessed by questionnaires at 3 and 12 months, included change ...
    • A rapid chemokine response of macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and the regulated on activation, normal T expressed and secreted chemokine is associated with a sustained virological response in the treatment of chronic hepatitis C 

      Florholmen, Jon; Kristiansen, Magnhild Gangsøy; Steigen, sonja eriksson; Sørbye, Sveinung Wergeland; Paulssen, Eyvind Jakob; Kvamme, J.M.; Zbigniew, Konopski; Gutteberg, tore jarl; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The role of chemokines in chronic hepatitis C virus (HCV) infection is not fully understood. The present study aimed to characterize the baseline serum concentrations and the initial β-chemokine response to treatment with interferon-α and ribavirin with respect to the final clinical outcome of virological response to treatment. Serum concentrations of alanine aminotransferase (ALT) and of the CC ...
    • Rapid extrication of entrapped victims in motor vehicle wreckage using a Norwegian chain method - cross-sectional and feasibility study 

      Fattah, Sabina; Johnsen, Anne Siri; Andersen, Jan Einar; Vigerust, Trond; Olsen, Terje; Rehn, Marius (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Rapid identification of pathogens, antibiotic resistance genes and plasmids in blood cultures by nanopore sequencing 

      Taxt, Arne Michael; Avershina, Ekaterina; Frye, Stephan Alfons; Naseer, Mohammed Umaer; Ahmad, Rafi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
      Bloodstream infections (BSI) and sepsis are major causes of morbidity and mortality worldwide. Blood culture-based diagnostics usually requires 1–2 days for identification of bacterial agent and an additional 2–3 days for phenotypic determination of antibiotic susceptibility pattern. With the escalating burden of antimicrobial resistance (AMR) rapid diagnostics becomes increasingly important to ...