Browsing Det helsevitenskapelige fakultet by Author "Aakhus, Svend"

Now showing items 1-7 of 7

    • Automatic measurements of left ventricular volumes and ejection fraction by artificial intelligence reduces time-consumption and inter-observer variability 

      Olaisen, Sindre Hellum; Espeland, Torvald; Smistad, Erik; Hu, Jieyu; Pasdeloup, David Francis Pierre; Østvik, Andreas; Amundsen, Brage H.; Aakhus, Svend; Rösner, Assami; Stylidis, Michael; Holte, Espen; Grenne, Bjørnar Leangen; Løvstakken, Lasse; Dalen, Håvard (Conference object; Konferansebidrag, 2023-06-19)

    • Automatic measurements of left ventricular volumes and ejection fraction by artificial intelligence: clinical validation in real time and large databases 

      Olaisen, Sindre Hellum; Smistad, Erik; Espeland, Torvald; Hu, Jieyu; Pasdeloup, David Francis Pierre; Østvik, Andreas; Aakhus, Svend; Rösner, Assami; Malm, Siri; Stylidis, Michael; Holte, Espen; Grenne, Bjørnar Leangen; Løvstakken, Lasse; Dalen, Håvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-26)
      Aims - Echocardiography is a cornerstone in cardiac imaging, and left ventricular (LV) ejection fraction (EF) is a key parameter for patient management. Recent advances in artificial intelligence (AI) have enabled fully automatic measurements of LV volumes and EF both during scanning and in stored recordings. The aim of this study was to evaluate the impact of implementing AI measurements on acquisition ...

    • Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction 

      Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Damås, Jan Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-29)
      <p><i>Aim</i>: To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI).</p> <p><i>Methods</i>: 117 patients with acute NSTEMI were randomised to an intravenous infusion of 280 mg tocilizumab or placebo prior to coronary angiography. Blood samples were obtained at baseline, at 6 consecutive ...

    • Predictors of early mortality after transcatheter aortic valve implantation 

      Kjønås, Didrik; Dahle, Gry; Schirmer, Henrik; Malm, Siri; Eidet, Jo; Aaberge, Lars; Steigen, Terje; Aakhus, Svend; Busund, Rolf; Rösner, Assami (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-23)
      <p><i>Objectives - </i>To investigate whether preoperative echocardiographic evaluation of ventricular function, especially right ventricular systolic and diastolic parameters including speckle-tracking analysis, could aid in the prediction of 30-day mortality after transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis. <p><i>Methods - </i>This is a prospective observational ...

    • Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction 

      Broch, Kaspar; Anstensrud, Anne Kristine; Woxholt, Sindre; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Aakhus, Svend; Ueland, Thor; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend; Bjørkelund, Elisabeth; Bendz, Christina; Hopp, Einar; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Andersen, Geir Øystein; Wiseth, Rune; Aukrust, Pål; Gullestad, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-12)
      <p><i>Background - </i>Prompt myocardial revascularization with percutaneous coronary intervention (PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, as much as 50% of the loss of viable myocardium may be attributed to the reperfusion injury and the associated inflammatory response. <p><i>Objectives - </i>This study sought ...

    • Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway 

      Kjønås, Didrik; Schirmer, Henrik; Malm, Siri; Eidet, Jo; Aaberge, Lars; Steigen, Terje; Aakhus, Svend; Busund, Rolf; Røsner, Assami; Dahle, Gry (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-06)
      Objectives: Transcatheter aortic valve implantation (TAVI)-specific risk scores have been developed based on large registry studies. Our aim was to evaluate how both surgical and novel TAVI risk scores performed in predicting all cause 30-day mortality. In addition, we wanted to explore the validity of our own previously developed model in a separate and more recent cohort.<p> <p>Methods: The ...

    • Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy 

      Abraityte, Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika E.; Christensen, Geir Arve; Aukrust, Pål; Yndestad, Arne; Fiane, Arnt; Andreassen, Arne; Aakhus, Svend; Dahl, Christen Peder; Gullestad, Lars; Broch, Kaspar; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-14)
      The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3 in plasma and myocardium of DCM patients and evaluated their effects on NFAT luciferase activity in neonatal mouse cardiomyocytes. Elevated circulating Wnt5a (n = 102) was associated ...