Blar i forfatter Det helsevitenskapelige fakultet "Augustijns, Patrick"

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    • Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network 

      Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah; Berben, Philippe; Bernkop-Schnürch, Andreas; Butler, James; Ceulemans, Jens; Davies, Nigel; Dupont, Didier; Flaten, Gøril Eide; Fotaki, Nikoletta; Griffin, Brendan T.; Jannin, Vincent; Keemink, Janneke; Kesisoglou, Filippos; Koziolek, Mirko; Kuentz, Martin; Mackie, Alan R.; Meléndez-Martínez, Antonio J.; McAllister, Mark; Müllertz, Anette; O'Driscoll, Caitriona M.; Parrott, Neil; Paszkowska, Jadwiga; Pavek, Petr; Porter, Christopher J.H.; Reppas, Christos; Stillhart, Cordula; Sugano, Kiyohiko; Toader, Elena; Valentová, Kateřina; Vertzoni, Maria; De Wildt, Saskia N.; Wilson, Clive G.; Augustijns, Patrick (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-18)
      Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption ...

    • Drug permeability profiling using cell-free permeation tools: Overview and applications 

      Berben, Philippe; Bauer-Brandl, Annette; Brandl, Martin; Faller, Bernard; Flaten, Gøril Eide; Jacobsen, Ann-Cathrine; Brouwers, Joachim; Augustijns, Patrick (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-13)
      Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are ...