• Bør vi spise mer fisk – eller mindre? 

      Bolann, Bjørn; Huber, Sandra; Averina, Maria; Eggesbø, Merete Åse; Hokstad, Ingrid; Brox, Jan; Ørebech, Peter Th; Monsen, Anne-Lise Bjørke (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)
    • Chronic iron deficiency and anaemia were highly prevalent in a population-based longitudinal study among adolescent girls 

      Stabell, Niklas; Averina, Maria; Flægstad, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)
      <b>Aim:</b> The combination of iron deficiency and anaemia is a major health problem, and adolescents are an at- risk group. The main aim of this study was to explore the mag-nitude of these conditions among adolescents aged 15–19 and identify possible as-sociated risk factors. <br><b>Methods:</b> This population- based longitudinal study of adolescents in North Norway was conducted in 2010–2011, ...
    • Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway 

      Cook, Sarah; Solbu, Marit Dahl; Eggen, Anne Elise; Iakunchykova, Olena; Averina, Maria; Hopstock, Laila Arnesdatter; Kholmatova, Kamila Kahramonzhonovna; Kudryavtsev, Alexander V; Leon, David A.; Malyutina, Sofia; Ryabikov, Andrew; Williamson, Elizabeth; Nitsch, Dorothea (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)
      Background - Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD.<p> <p>Methods - We compared age- and sex-standardised prevalence of ...
    • Early menarche and other endocrine disrupting effects of per- and polyfluoroalkyl substances (PFAS) in adolescents from Northern Norway. The Fit Futures study 

      Averina, Maria; Huber, Sandra; Almås, Bjørg; Brox, Jan; Jacobsen, Bjarne K.; Furberg, Anne-Sofie; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-19)
      Background: Per- and polyfluoroalkyl substances (PFAS) comprise a large group of chemicals that are ubiquitous in the environment and include recognized persistent organic pollutants. The aim of this cross-sectional study was to investigate possible endocrine disrupting effects of different PFAS in adolescents. <p> <p>Methods: Serum concentrations of PFAS, thyroid, parathyroid and steroid hormones ...
    • Evidence for a direct harmful effect of alcohol on myocardial health: A large cross-sectional study of consumption patterns and cardiovascular disease risk biomarkers from northwest Russia, 2015 to 2017 

      Iakunchykova, Olena; Averina, Maria; Kudryavtsev, Alexander V; Wilsgaard, Tom; Soloviev, Andrey; Schirmer, Henrik; Cook, Sarah Anne; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
      <i>Background</i> - Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarkers of cardiac damage and inflammation.<p><p> <i>Methods and Results</i> - The Know Your ...
    • Heavy alcohol drinking and subclinical echocardiographic abnormalities of structure and function 

      Iakunchykova, Olena; Schirmer, Henrik; Leong, Darryl; Malyutina, Sofia; Ryabikov, Andrey; Averina, Maria; Kudryavtsev, Alexander V; Kornev, Mikhail; Voronina, Ekaterina; Paramonov, Andrey; Wilsgaard, Tom; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-02)
      Objective - The aim of the study is to assess changes in heart structure and function associated with heavy alcohol use by comparing echocardiographic indices in a population-based sample to those in patients admitted to an inpatient facility with severe alcohol problems.<p> <p>Methods and results - We used data from the Know Your Heart study (2015–2017) which is a cross-sectional study that ...
    • Høyt nivå av tungmetaller i krabbe 

      Averina, Maria; Monsen, Anne-Lise Bjørke; Bolann, Bjørn Johan; Brox, Jan; Eggesbø, Merete; Hokstad, Ingrid; Huber, Sandra; Ørebech, Peter Th (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-01)
      Krabber er populær sjømat, men kan inneholde til dels store mengder miljøgifter. Innholdet er mange steder i Norge så høyt at inntak av brunmaten generelt bør frarådes.
    • Investigation of background contribution from different solvent brands used for sample preparation and analysis of persistent organic pollutants 

      Götsch, Arntraut; Averina, Maria; Brox, Jan; Huber, Sandra (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
      In the times of pandemic, we experienced problems with supply bottlenecks for the solvents normally used for extraction and analysis of persistent organic pollutants (POPs; i.e. PCBs, PBDEs and organochlorine pesticides) in our laboratory and, considered to start using solvents from another producer alternatively. Since we analyze POPs at very low concentration levels and other consumables are ...
    • Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35-69 years from two Russian cities, 2015-18 

      Cook, Sarah; Malyutina, S; Kudryavtsev, Alexander; Averina, Maria; Bobrova, Natalia; Boytsov, S; Brage, S; Clark, TG; Diez Benavente, S; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Hughes, A; Johansen, Heidi; Kholmatova, Kamila; Kichigina, A; Kontsevaya, Anna; Kornev, M; Leong, D; Magnus, Per; Mathiesen, Ellisiv B.; McKee, M; Morgan, K; Nilssen, Odd-Ragnar; Plakhov, I; Quint, JK; Rapala, A; Ryabikov, A; Saburova, Lyudmila; Schirmer, Henrik; Shapkina, M; Shiekh, Suhail; Shkolnikov, VM; Stylidis, Michael; Voevoda, Mikhail; Westgate, Kate; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-04)
      Russia has one of the highest rates of cardiovascular disease in the world. The International Project on Cardiovascular Disease in Russia (IPCDR) was set up to understand the reasons for this. A substantial component of this study was the Know Your Heart Study devoted to characterising the nature and causes of cardiovascular disease in Russia by conducting large cross-sectional surveys in two Russian ...
    • Laktat i fosterskalpblodprøve som markør for føtal hypoksi 

      Fosse, Gunhild Øygard; Averina, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-11)
      Evidensgrunnlaget for å ta blodprøver fra fosterskalpen er svakt. Fører prøvene til færre intervensjoner eller bedre utfall for fosteret?
    • Longitudinal changes in blood biomarkers and their ability to predict type 2 diabetes mellitus—The Tromsø study 

      Allaoui, Giovanni; Rylander, Charlotta; Averina, Maria; Wilsgaard, Tom; Fuskevåg, Ole Martin; Berg, Vivian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-11)
      Introduction: Identification of individuals at high risk of developing type 2 diabetes mellitus (T2DM) is important for early prevention of the disease. Once T2DM is established, it is difficult to treat and is associated with cardiovascular complications and increased mortality. We aimed to describe pre- and post-diagnostic changes in blood biomarker concentrations over 30 years in individuals ...
    • Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus 

      Charles, Dolley; Berg, Vivian; Nøst, Therese Haugdahl; Bergdahl, Ingvar A.; Huber, Sandra; Ayotte, Pierre; Wilsgaard, Tom; Averina, Maria; Sandanger, Torkjel M; Rylander, Charlotta (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)
      Background: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In addition, physiological risk factors for T2DM may also influence POP concentrations, contributing to ...
    • NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population 

      Averina, Maria; Stylidis, Michael; Brox, Jan; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-23)
      Aims The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population.<p> <p>Methods and results Altogether, 1936 participants were randomly selected ...
    • Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis 

      Charles, Dolley; Berg, Vivian; Nøst, Therese Haugdahl; Wilsgaard, Tom; Bergdahl, Ingvar A.; Huber, Sandra; Ayotte, Pierre; Averina, Maria; Sandanger, Torkjel M; Rylander, Karin Charlotta Maria (Journal article; Tidsskriftartikkel, 2023-03-05)
      <p><i>Background:</i> Previous studies have reported associations between certain persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM). Polybrominated diphenyl ethers (PBDEs) are a class of POPs that are found in increasing concentrations in humans. Although obesity is a known risk factor for T2DM and PBDEs are fat-soluble, very few studies have investigated associations between ...
    • A population based study on cardiovascular diseases in Northwest Russia : the Arkhangelsk study 2000 

      Averina, Maria (Doctoral thesis; Doktorgradsavhandling, 2005)
      This study was designed and carried out in Arkhangelsk to investigate reasons for high CVD mortality/morbidity in Northwest of Russia. It revealed that the high CVD morbidity and mortality in this population could not be explained only by the classical CVD risk factors (blood pressure, serum lipids, smoking). Lipid profile was especially favorable. These results from the Arkhangelsk study are ...
    • Prediction of chronic heart failure and chronic obstructive pulmonary disease in a general population: the Tromsø study 

      Melbye, Hasse; Stylidis, Michael; Aviles Solis, Juan Carlos; Averina, Maria; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-07)
      <i>Aims</i> - Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are main causes of dyspnoea, and echocardiography and spirometry are essential investigations for these diagnoses. Our aim was to determine the prevalence of HF and COPD in a general population, also how the diseases may be identified, and to what extent their clinical characteristics differ.<br><br> <i>Methods and ...
    • Quantitation of linear and branched perfluoroalkane sulfonic acids (PFSAs) in women and infants during pregnancy and lactation 

      Varsi, Kristin; Huber, Sandra; Averina, Maria; Brox, Jan; Monsen, Anne-Lise Bjørke (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-24)
      Background: Per- and polyfluoroalkyl substances (PFAS) are associated with negative health effects, and exposure during fetal life and infancy are of concern. A subgroup of PFAS, linear and branched perfluoroalkane sulfonic acids (PFSA), have significant differences in biochemical reactions, bioaccumulation and potential toxic exposure effects, and data on transfer of PFSA isomers from mother to ...
    • Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway 

      Averina, Maria; Brox, Jan; Huber, Sandra; Furberg, Anne-Sofie; Sørensen, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      <b>Background:</b> Exposure to environmental pollutants may contribute to the development of asthma and other allergies. The aim of this study was to investigate possible associations between asthma and other allergies with exposure to perfluoroalkyl substances (PFASs) in adolescents from the Arctic region of Norway.<br><b> Methods</b> The Tromsø study Fit Futures 1 (TFF1) and 3-year follow-up Fit ...
    • What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity 

      Iakunchykova, Olena; Averina, Maria; Wilsgaard, Tom; Malyutina, Sofia; Kudryavtsev, Alexander V; Cook, Sarah; Wild, Sarah; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-04)
      <i>Introduction</i> - Compared with many other countries Russia has a high prevalence of diabetes in men and women. However, contrary to what is found in most other populations, the risk is greater among women than men. The reasons for this are unclear.<br><br> <i>Research design and methods</i> - Prevalence and risk factors for diabetes at ages 40–69 years were compared in two population-based ...
    • Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage 

      Iakunchykova, Olena; Averina, Maria; Wilsgaard, Tom; Watkins, Hugh; Malyutina, Sofia; Ragino, Yulia; Keogh, Ruth; Kudryavtsev, Alexander V; Govorun, Vadim; Cook, Sarah Anne; Schirmer, Henrik; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-15)
      <p><i>Background - </i>Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial difference in risk. <p><i>Methods - </i>We compared age-standardised mean levels of CVD ...