Blar i forfatter Det helsevitenskapelige fakultet "Ebert, Matthias P."

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    • In vitro generation of functional liver organoid-like structures using adult human cells 

      Ramachandran, Sarada Devi; Schirmer, Katharina; Münst, Bernhard; Heinz, Stefan; Ghafoory, Shahrouz; Wölfl, Stefan; Simon-Keller, Katja; Marx, Alexander; Øie, Cristina Ionica; Ebert, Matthias P.; Walles, Heike; Braspenning, Joris; Breitkopf-Heinlein, Katja (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-21)
      In this study we used differentiated adult human upcyte1 cells for the in vitro generation of liver organoids. Upcyte1 cells are genetically engineered cell strains derived from primary human cells by lenti-viral transduction of genes or gene combinations inducing transient proliferation capacity (upcyte1 process). Proliferating upcyte1 cells undergo a finite number of cell divisions, i.e., ...