Blar i forfatter Det helsevitenskapelige fakultet "Freyd, Thibaud"

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    • Allosteric modulation of GABAergic and glutamatergic metabotropic receptors 

      Freyd, Thibaud (Doctoral thesis; Doktorgradsavhandling, 2018-09-10)
      G-protein coupled receptors (GPCRs) are targets for 1/3 of the drugs available on the market making research on this class of proteins a very hot topic in the field of drug discovery. γ-amino butyric acid (GABA) and glutamate are respectively the main inhibitory and the main excitatory neurotransmitters in the mammalian central nervous system (CNS). The GABAB receptor (GABAB-R) and the metabotropic ...

    • Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling 

      Fjelldal, Marthe Fredheim; Freyd, Thibaud; Evenseth, Linn; Sylte, Ingebrigt; Ring, Avi; Paulsen, Ragnhild Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-30)
      N‐methyl‐d‐aspartate receptors (NMDAR) are widely expressed in the brain. GluN2B subunit‐containing NMDARs has recently attracted significant attention as potential pharmacological targets, with emphasis on the functional properties of allosteric antagonists. We used primary cultures from chicken embryo forebrain (E10), expressing native GluN2B‐containing NMDA receptors as a novel model system. ...

    • Ligand-guided homology modelling of the GABAb2 subunit of the GABAb receptor 

      Freyd, Thibaud; Warszycki, Dawid; Mordalski, Stefan; Bojarski, Andrzej J; Sylte, Ingebrigt; Gabrielsen, Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-21)
      γ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, and disturbances in the GABAergic system have been implicated in numerous neurological and neuropsychiatric diseases. The GABA<sub>B</sub> receptor is a heterodimeric class C G protein-coupled receptor (GPCR) consisting of GABA<sub>B1a/b</sub> and GABA<sub>B2</sub> subunits. Two GABA<sub>B</sub> receptor ...