Blar i forfatter Det helsevitenskapelige fakultet "Fridholm, Helena"

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    • Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms 

      Harms, Klaus; Lunnan, Asbjørn; Hulter, Nils; Mourier, Tobias; Vinner, Lasse; Andam, Cheryl P; Marttinen, Pekka; Fridholm, Helena; Hansen, Anders Johannes; Hanage, William P; Nielsen, Kaare Magne; Willerslev, Eske; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-27)
      In a screen for unexplained mutation events we identified a previously unrecognized mechanism generating clustered DNA polymorphisms such as microindels and cumulative SNPs. The mechanism, short-patch double illegitimate recombination (SPDIR), facilitates short single-stranded DNA molecules to invade and replace genomic DNA through two joint illegitimate recombination events. SPDIR is controlled by ...