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    • Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders 

      Singh, Katyayani; Jayaram, Mohan; Kaare, Maria; Leidmaa, Este; Jagomäe, Toomas; Heinla, Indrek; Hickey, Miriam A.; Kaasik, Allen; Schäfer, Michael K.; Innos, Jürgen; Lilleväli, Kersti; Philips, Mari-Anne; Vasar, Eero (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-01)
      Neuronal growth regulator 1 (NEGR1) belongs to the immunoglobulin (IgLON) superfamily of cell adhesion molecules involved in cortical layering. Recent functional and genomic studies implicate the role of NEGR1 in a wide spectrum of psychiatric disorders, such as major depression, schizophrenia and autism. Here, we investigated the impact of <i>Negr1</i> deficiency on brain morphology, neuronal ...