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    • Polymorphisms on PAI-1 and ACE genes in association with fibrinolytic bleeding after on-pump cardiac surgery 

      Ozolina, Agnese; Strike, Eva; Nikitina-Zake, Liene; Jaunalksne, Inta; Krumina, Angelika; Lacis, Romans; Bjertnæs, Lars J.; Vanags, Indulis (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-04)
      Background: Carriers of plasminogen activator inhibitor -1 (PAI-1) -675 genotype 5G/5G may be associated with lower preoperative PAI-1 plasma levels and higher blood loss after heart surgery using cardiopulmonary bypass (CPB). We speculate if polymorphisms of PAI-1 -844 A/G and angiotensin converting enzyme (ACE) intron 16 I/D also might promote fibrinolysis and increase postoperative bleeding. ...