Blar i forfatter Det helsevitenskapelige fakultet "Lunde, Tracy Munthali"

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    • Antibiotic Resistance in Oral Streptococci: The prevalence, diversity, stability, and fitness cost of Tn916 -Tn1545 family in oral streptococcal isolates 

      Lunde, Tracy Munthali (Doctoral thesis; Doktorgradsavhandling, 2022-03-25)
      Oral streptococci are important members of the oral microbiome that are gathering more attention due to the presence of antimicrobial resistance determinants and their association with mobile genetic elements. Mobile genetic elements such as the ICE, Tn916 are abundant in bacterial populations and have been implicated in the spread of antibiotic resistance. Despite their abundance, little is known ...

    • Determination of copy number and circularization ratio of Tn916-Tn1545 family of conjugative transposons in oral streptococci by droplet digital PCR 

      Lunde, Tracy Munthali; Al-Haroni, Mohammed; Roberts, Adam P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-06)
      <p><I>Background</I>: Tn916 and Tn1545 are paradigms of a large family of related, broad host range, conjugative transposons that are widely distributed in bacteria and contribute to the spread of antibiotic resistance genes (ARGs). Variation in the copy number (CN) of Tn916-Tn1545 elements and the circularization ratio (CR) may play an important role in propagation of ARGs carried by these ...

    • Prevalence, diversity and transferability of the Tn916-Tn1545 family ICE in oral streptococci 

      Lunde, Tracy Munthali; Hjerde, Erik; Al-Haroni, Mohammed (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-15)
      <i>Background</i>: The Tn<i>916</i>-Tn<i>1545</i> family of Integrative Conjugative Elements (ICE) are mobile genetic elements (MGEs) that play a role in the spread of antibiotic resistance genes. The Tn<i>916</i> harbors the tetracycline resistance gene <i>tet</i>(M) and it has been reported in various bacterial species. The increase in the levels of tetracycline resistance among oral streptococci ...

    • A Trade-off between the Fitness Cost of Functional Integrases and Long-term stability of Integrons 

      Starikova, Irina; Harms, Klaus; Haugen, Pål; Lunde, Tracy Munthali; Primicerio, Raul; Samuelsen, Ørjan; Nielsen, Kaare Magne; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Horizontal gene transfer (HGT) plays a major role in bacterial microevolution as evident from the rapid emergence and spread of antimicrobial drug resistance. Few studies have however addressed the population dynamics of newly imported genetic elements after HGT. Here, we show that newly acquired class-1 integrons from Salmonella enterica serovar Typhimurium and Acinetobacter baumannii, free of ...