Blar i forfatter Det helsevitenskapelige fakultet "Næsheim, Torvind"

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    • Abstracts from The Cold Weather Operations Conference 2021 

      Norheim, Arne Johan; Rannestad, Bård Stian; Howes, Richard; Rein, Erling Bekkestad; Jørum, Ellen; Friedl, Karl; Havenith, George; Teien, Hilde Kristin; Mercer, James; Melau, Jørgen; de Weerd, Louis; Smith, Michael; Taylor, Natalie; Voie, Øyvind Albert; Bergan-Skar, Pål; Andrews, Steve; Næsheim, Torvind; Steinberg, Tuva (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-11)
      A common effort for both military and civil healthcare is to achieve knowledge-based health care in cold weather injuries and fatal accidents in harsh arctic environment. The Cold Weather Operations Conference in November 2021, having more than 300 participants from 20 countries, was addressing the prevention and treatment of injuries and trauma care in cold weather conditions and the challenges for ...

    • The effect of Riociguat on cardiovascular function and efficiency in healthy, juvenile pigs 

      Næsheim, Torvind; How, Ole-Jakob; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-12)
      <p><i>Introduction - </i>Riociguat is a soluble guanylate cyclase stimulator approved for the treatment of pulmonary hypertension. Its effect on cardiometabolic efficiency is unknown. A potential cardiac energy sparing effect of this drug could imply a positive prognostic effect, particularly in patients with right heart failure from pulmonary hypertension. <p><i>Method - </i>We infused Riociguat ...

    • Guanylate cyclase activators and stimulators. Potential cardiovascular therapeutics, with special focus on the right ventricle 

      Næsheim, Torvind (Doctoral thesis; Doktorgradsavhandling, 2022-09-09)
      <p><i>Background -</i> Soluble guanylate cyclase, sGC, is a major contributor to the signal transduction in the cardiovascular system, and dysfunction in the NO-sGC-cGMP signaling plays an important role in cardiovascular disease. This system is sensitive to a wide variety of pathological conditions spanning from substrate shortage to sGC-insensitivity to nitric oxide (NO), during pathological ...

    • Health-related quality of life after extracorporeal membrane oxygenation: a single centre's experience 

      Ørbo, Marte; Karlsen, Sidsel Fredheim; Pedersen, Ellinor Phillips; Hermansen, Stig Eggen; Rønning, Per Bjørnerud; Aas, Kathrine Nergård; Næsheim, Torvind; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-07)
      <i>Aims</i>: The aims of this study were to evaluate health-related quality of life (HRQL) among patients treated with extracorpo-real membrane oxygenation (ECMO) in northern Norway over a period of 27years (1988–2015) and to identify variables related to HRQL.<p> <p><i>Methods and results</i>: A retrospective inquiry of the ECMO registry at the University Hospital of North Norway identified 74 ...

    • Hemodynamic effects of a soluble guanylate cyclase stimulator, Riociguat, and an activator, Cinaciguat, during NO-modulation in healthy pigs 

      Næsheim, Torvind; How, Ole-Jakob; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-14)
      Cardiovascular diseases are often characterized by dysfunctional endothelium. To compensate for the related lack of nitric oxide (NO), a class of soluble guanylate cyclase (sGC) stimulators and activators have been developed with the purpose of acting downstream of NO in the NO-sGC-cGMP cascade. These drugs have been discovered using photoaffinity labeling of sGC and high-throughput screening of a ...

    • Hypothermic cardiac arrest far away from the center providing rewarming with extracorporeal circulation. 

      Mark, Eckhard; Jacobsen, Olaf; Kjerstad, Astrid Kristine; Næsheim, Torvind; Busund, Rolf; Bahar, Ramez; Jensen, Jon Kjetil; Skorpen, Per Kristian; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      A 41-year-old man suffered hypothermic cardiac arrest after water immersion and was transported to our university hospital by ambulance helicopter for rewarming on cardiopulmonary bypass. He resumed spontaneous cardiac activity 6 h 52 min after cardiac arrest and recovered completely.

    • Offshore telementored ultrasound: a quality assessment study 

      Vatsvåg, Victoria; Todnem, Kjetil; Næsheim, Torvind; Cathcart, John; Kerr, Daniel; Oveland, Nils Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-02)
      <p><i>Background - </i>Telementored ultrasound (US) connects experts to novices through various types of communication and network technologies with the overall aim to bridge the medical imaging gap between patients’ diagnostic needs and on-site user experience. The recurrent theme in previous research on remote telementored US is the limited access to US machines and experienced users. This study ...

    • Physiological Changes in Subjects Exposed to Accidental Hypothermia: An Update 

      Bjertnaes, Lars J.; Næsheim, Torvind; Reierth, Eirik; Suborov, Evgeny; Kirov, Mikhail; Lebedinskii, Konstantin M.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-23)
      Background: Accidental hypothermia (AH) is an unintended decrease in body core temperature (BCT) to below 35°C. We present an update on physiological/pathophysiological changes associated with AH and rewarming from hypothermic cardiac arrest (HCA).<p> <p>Temperature Regulation and Metabolism: Triggered by falling skin temperature, Thyrotropin-Releasing Hormone (TRH) from hypothalamus induces ...

    • Rewarming From Hypothermic Cardiac Arrest Applying Extracorporeal Life Support: A Systematic Review and Meta-Analysis 

      Bjertnæs, Lars J.; Hindberg, Kristian; Næsheim, Torvind; Suborov, Evgeny V.; Reierth, Eirik; Kirov, Mikhail Y.; Lebedinskii, Konstantin M.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-13)
      <i>Introduction</i>: This systematic review and meta-analysis aims at comparing outcomes of rewarming after accidental hypothermic cardiac arrest (HCA) with cardiopulmonary bypass (CPB) or/and extracorporeal membrane oxygenation (ECMO).<br><br> <i>Material and Methods</i>: Literature searches were limited to references with an abstract in English, French or German. Additionally, we searched ...

    • Study of the effects of 3 h of continuous cardiopulmonary resuscitation at 27°C on global oxygen transport and organ blood flow 

      Nilsen, Jan Harald; Valkov, Sergei; Mohyuddin, Rizwan; Schanche, Torstein Lindahl; Kondratiev, Timofei V.; Næsheim, Torvind; Sieck, Gary C.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-16)
      <i>Aims</i>: Complete restitution of neurologic function after 6 h of pre-hospital resuscitation and in-hospital rewarming has been reported in accidental hypothermia patients with cardiac arrest (CA). However, the level of restitution of circulatory function during long-lasting hypothermic cardiopulmonary resuscitation (CPR) remains largely unknown. We compared the effects of CPR in replacing ...