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    • Tigecycline attenuates polymorphonuclear leukocyte (PMN) receptors but not functions 

      Næss, Are; Andreeva, Hristina D; Sørnes, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Tigecycline achieves high intracellular concentrations in polymorphonuclear leukocytes (PMNs). To evaluate the effects of tigecycline on human PMNs, PMNs were incubated with tigecycline dilutions (0.1 to 100 mg L–1). Phagocytosis- associated PMN Fcg- and complement receptors as well as phagocytosis and oxidative burst induced by Staphylococcus aureus were measured by flow cytometry. Incubation ...