Blar i forfatter Det helsevitenskapelige fakultet "Naderkhani, Elenaz"
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Biomimetic PVPA in vitro model for estimation of the intestinal drug permeability using fasted and fed state simulated intestinal fluids
Naderkhani, Elenaz; Vasskog, Terje; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-20)A prerequisite for successful oral drug therapy is the drug’s ability to cross the gastrointestinal barrier. Considering the increasing number of new chemical entities in modern drug discovery, reliable and fast in vitro models are required for early and efficient prediction of intestinal permeability. To mimic the intestinal environment, use of biorelevant media may provide valuable information ... -
Development of a biomimetic phospholipid vesicle-based permeation assay for the estimation of intestinal drug permeability
Naderkhani, Elenaz; Isaksson, Johan; Ryzhakov, Alexey; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Development of biomimetic phospholipid vesicle-based permeation assays (PVPA) as screening tool in drug development
Naderkhani, Elenaz (Doctoral thesis; Doktorgradsavhandling, 2015-04-17)Although several routes of administration can be utilized to bring a drug to the desired site of action, oral administration is still the most important and prevalent route of administration, due to its cost efficiency, convenience and patient compliance. A prerequisite for successful oral therapy is the ability of a drug to cross the gastrointestinal barrier. Over the past two decades, the ... -
Improved Permeability of Acyclovir: Optimization of Mucoadhesive Liposomes Using the Phospholipid Vesicle-Based Permeation Assay
Naderkhani, Elenaz; Erber, Astrid; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-01-06) -
Investigation and optimization of liposome formulation for use as drug carrier for the anticancer agent Camptothecin
Naderkhani, Elenaz (Master thesis; Mastergradsoppgave, 2011-06-09)In this thesis, the method development and investigation of different liposomal formulations to incorporate and retain Camptothecin (CPT) is described. CPT is a potent anticancer drug that has shown to be active against a broad spectrum of cancers. However, due to its challenging physicochemical properties, like poor water solubility, severe toxic effects to normal tissues and instability, its ...