Infected chronic skin wounds and other skin infections are increasingly putting pressure on the health care providers and patients. The pressure is especially concerning due to the rise of antimicrobial resistance and biofilm-producing bacteria that further impair treatment success. Therefore, innovative strategies for wound healing and bacterial eradication are urgently needed; utilization ...

The rather limited success of translation from basic research to clinical application has been highlighted as a major issue in the nanomedicine field. To identify the factors influencing the applicability of nanosystems as drug carriers and potential nanomedicine, we focused on following their fate through fluorescence-based assays, namely flow cytometry and imaging. These methods are often used to ...

<p><i>Introduction - </i>Laeverin is a placenta‐specific protein that is normally expressed in the plasma membrane of human trophoblasts. In previous studies, we showed higher expression levels of laeverin gene in preeclamptic compared with normal placentas and found that laeverin protein was ectopically expressed in the cytoplasm of the preeclamptic placentas. Our objective was to investigate ...

<i>Objective</i>: The aim of this study was to compare the laeverin level in maternal serum from first trimester (11–14 weeks) of pregnancy between normal pregnancies and pregnancies that later developed preeclampsia (PE).<p><p> <i>Material and methods</i>: This was a case-cohort study. The laeverin concentration was measured in cases with preterm PE (<i>n</i> = 55), term PE (<i>n</i> = 95), and ...

Preeclampsia is a pregnancy-specific disease, affecting 5-10% of human pregnancies worldwide. It is defined as new-onset hypertension after 20 weeks of gestation with either proteinuria and/or organ failure. Laeverin is a membrane-bound aminopeptidase exclusively expressed in the placenta. Our previous studies revealed a significant upregulation of laeverin mRNA in preeclamptic placentas, building ...