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    • Silenced vanA gene cluster on a transferable plasmid cause outbreak of vancomycin variable enterococci 

      Sivertsen, Audun; Pedersen, Torunn Annie; Larssen, Kjersti Wik; Bergh, Kåre; Rønning, Torunn Gresdal; Radtke, Andreas; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-02)
      We report an outbreak of vancomycin-variable vanA+ enterococci (VVE) able to escape phenotypic detection by current guide- lines and demonstrate the molecular mechanisms for in vivo switching into vancomycin resistance and horizontal spread of the vanA cluster. Forty-eight vanA+ Enterococcus faecium isolates and one Enterococcus faecalis isolate were analyzed for clonality with pulsed-field ...