Blar i forfatter Det helsevitenskapelige fakultet "Tho, Ingunn"

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    • Bioadhesive Mini-Tablets for Vaginal Drug Delivery 

      Hiorth, Marianne; Nilsen, Susanne; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-08-27)

    • Chitosan in Mucoadhesive Drug Delivery: Focus on Local Vaginal Therapy 

      Andersen, Toril; Bleher, Stefan; Flaten, Gøril Eide; Tho, Ingunn; Mattsson, Sofia; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-07)
      Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today’s drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers means to improve mucosal drug therapy. We have used chitosan as mucoadhesive polymer to develop liposomes able to ensure prolonged residence time at vaginal site. Two types of ...

    • Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes 

      Andersen, Toril; Mishchenko, Ekaterina; Flaten, Gøril Eide; Sollid, Johanna U Ericson; Mattsson, Sofia; Tho, Ingunn; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-04)
      Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal therapy; the chitosan-based nanosystem could both provide antifungal effects and ...

    • Chitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effect 

      Jøraholmen, May Wenche; Vanić, Željka; Tho, Ingunn; Škalko-Basnet, Nataša (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      The choice of drug therapy in pregnant patients suffering from vaginal infections is limited by the safety profile of the drug. Assuring the efficient topical therapy to avoid systemic absorption is considered the best therapy option. Chitosan-coated liposomes have been developed and optimized to assure localized therapy of clotrimazole. Chitosan was selected as mucoadhesive polymer both to prolong ...

    • Development and evaluation of a test program for Y-site compatibility testing of total parenteral nutrition and intravenous drugs 

      Staven, Vigdis; Wang, Siri; Grønlie, Ingrid; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-22)
      Background: There is no standardized procedure or consensus to which tests should be performed to judge compatibility/ incompatibility of intravenous drugs. The purpose of this study was to establish and evaluate a test program of methods suitable for detection of physical incompatibility in Y-site administration of total parenteral nutrition (TPN) and drugs. Methods: Eight frequently used methods ...

    • Impact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tablets 

      Larsen, Bjarke Strøm; Kissi, Eric Ofosu; Parreiras Nogueira, Liebert; Genina, Natalja; Tho, Ingunn (Journal article; Tidsskriftartikkel, 2023-11-02)
      <p>This study investigates the influence of drug load and polymer molecular weight on the structure of tablets three-dimensionally (3D) printed from the binary mixture of prednisolone and hydroxypropyl methylcellulose (HPMC). Three different HPMC grades, (AFFINISOLTM HPMC HME 15LV, 90 Da (HPMC 15LV); 100LV, 180 Da (HPMC 100LV); 4M, 500 Da (HPMC 4M)), which are suitable for hot-melt extrusion (HME), ...

    • Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold 

      Alopaeus, Julia Fredrika; Hellfritzsch, Marie; Gutowski, Tobias; Scherließ, Regina; Almeida, Andreia F; Sarmento, Bruno; Skalko-Basnet, Natasa; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-07)
      From a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without the need of swallowing, and improved patient safety. The aim of the presented work was to prepare a buccal film using a self-forming micellar drug solubiliser as the film matrix, combining it with a mucoadhesive polymer for an enhanced retention on the buccal mucosa. Specifically, ...

    • Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method 

      Andersen, Toril; Vanic, Zeljka; Flaten, Gøril Eide; Mattsson, S.; Tho, Ingunn; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Mucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive polymers. The aim of this study was to develop novel mucoadhesive system by the one-pot preparation method. ...

    • Physical stability of an all-in-one parenteral nutrition admixture for preterm infants upon mixing with micronutrients and drugs 

      Staven, Vigdis; Wang, Siri; Grønlie, Ingrid; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-07)
      <p><I>Objectives</I>: The main objective was to investigate Y-site compatibility of intravenous drugs with one standard total parenteral nutrition (TPN) admixture for preterm infants. Since micro-precipitation was observed in the water phase after addition of trace elements, the concentration effect on micro-precipitation formation developed as a sub-goal.</p> <p><I>Methods</I>: Seven drugs ...

    • Use of 3-D modelling in early development phase of pectin tablets 

      Salbu, Linda; Picker-Freyer, Katharina M.; Schmid, Wolfgang; Bauer-Brandl, Annette; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      This study examines the contribution of the 3-D model in an early development set-up for pectin tablets. Therefore, the aim of this work is to extract as much information on the compression behaviour from as few tablets as possible. Pectins with various degrees of methoxylation (DM) were studied (4-72%). The compressibility was evaluated by classical “in-die” Heckel and Kawakita analyses in addition ...