Now showing items 1-4 of 4

    • The enterococcus cassette chromosome, a genomic variation enabler in enterococci 

      Sivertsen, Audun; James Peter, Jessin Janice; Pedersen, Torunn Annie; Wagner, Theresa; Hegstad, Joachim; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-07)
      Enterococcus faecium has a highly variable genome prone to recombination and horizontal gene transfer. Here, we have identified a novel genetic island with an insertion locus and mobilization genes similar to those of staphylococcus cassette chromosome elements SCCmec. This novel element termed the enterococcus cassette chromosome (ECC) element was located in the 3′ region of rlmH and encoded large ...
    • Enterococcus faecium produces membrane vesicles containing virulence factors and antimicrobial resistance related proteins 

      Wagner, Theresa; Joshi, Bishnu; James Peter, Jessin Janice; Askarian, Fatemeh; Skalko-Basnet, Natasa; Hagestad, Ole Christian; Mekhlif, Ahmed; Wai, Sun Nyunt; Hegstad, Kristin; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-30)
      <i>Enterococcus faecium</i> is a commensal but also a bacteremia causing pathogen, which is inherently resistant to several antimicrobials and has a great ability to acquire new traits. Bacterial membrane vesicles (MVs) are increasingly recognized as a mode of cell-free communication and a way to deliver virulence factors and/or antimicrobial resistance determinants. These features make MVs interesting ...
    • Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood 

      Wagner, Theresa; James Peter, Jessin Janice; Paganelli, Fernanda; Willems, Rob J.L.; Askarian, Fatemeh; Pedersen, Torunn Annie; Top, Janetta; de Haas, Carla; van strijp, Jos A. G.; Johannessen, Mona; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-03)
      <i>Enterococcus faecium</i> has undergone a transition to a multidrug-resistant nosocomial pathogen. The population structure of <i>E. faecium</i> is characterized by a sharp distinction of clades, where the hospital-adapted lineage is primarily responsible for bacteremia. So far, factors that were identified in hospital-adapted strains and that promoted pathogenesis of nosocomial <i>E. faecium</i> ...
    • How to Be a Bad Bug: Virulence Determinants of Enterococcus faecium 

      Wagner, Theresa (Doctoral thesis; Doktorgradsavhandling, 2018-10-18)
      Enterococcus faecium is a ubiquitous bacterium that only recently emerged as a nosocomial pathogen. Infections mostly affect immunocompromised patients and multi-resistance of E. faecium often hampers treatment. This thesis focuses on determinants, which give pathogenic potential to E. faecium. In the first paper, two TirE proteins are described as novel virulence factors of E. faecium. The tirE ...