Blar i forfatter Det helsevitenskapelige fakultet "Werb, Zena"

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    • Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome 

      Winkler, Juliane; Liu, Pengyuan; Phong, Kiet; Hinrichs, Johanna H.; Ataii, Nassim; Williams, Katherine; Hadler-Olsen, Elin Synnøve; Samson, Susan; Gartner, Zev J.; Fisher, Susan; Werb, Zena (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-09)
      Environmental chemicals such as bisphenol A (BPA) are thought to contribute to carcinogenesis through their endocrine-disrupting properties. Due to accumulating evidence about negative human health effects, BPA is being phased out, but in parallel, exposures to replacement chemicals such as bisphenol S (BPS) and bisphenol F (BPF) are increasing. Little is known about their biologic effects, but ...

    • MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy 

      Owyong, Mark; Chou, Jonathan; van den Bijgaart, Renske; Kong, Niwen; Efe, Gizem; Maynard, Carrie; Talmi-Frank, Dalit; Solomonov, Inna; Koopman, Charlotte; Hadler-Olsen, Elin Synnøve; Headley, Mark; Lin, Charlene; Wang, Chih-Yang; Sagi, Irit; Werb, Zena; Plaks, Vicki (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-14)
      Metastasis, the main cause of cancer-related death, has traditionally been viewed as a late-occurring process during cancer progression. Using the MMTV-PyMT luminal B breast cancer model, we demonstrate that the lung metastatic niche is established early during tumorigenesis. We found that matrix metalloproteinase 9 (MMP9) is an important component of the metastatic niche early in tumorigenesis and ...