English
norskBlar i forfatter Det helsevitenskapelige fakultet "Wist, Erik"
Viser treff 1-9 av 9
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Disseminated tumor cells as selection marker and monitoring tool for secondary adjuvant treatment in early breast cancer. Descriptive results from an intervention study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-12-22)Background: Presence of disseminated tumor cells (DTCs) in bone marrow (BM) after completion of systemic adjuvant treatment predicts reduced survival in breast cancer. The present study explores the use of DTCs to identify adjuvant insufficiently treated patients to be offered secondary adjuvant treatment intervention, and as a surrogate marker for therapy response.<p> <p>Methods: A total of ... -
Gene variations in oestrogen pathways, CYP19A1 , daily 17ß-estradiol and mammographic density phenotypes in premenopausal women.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-12-19) -
Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-15)<i>Background</i>: High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear.<p> <p><i>Methods</i>: A population-based survival study among 464 breast cancer cases ... -
Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-03)Growing evidence indicates that adiposity is associated with breast cancer risk and negatively affects breast cancer recurrence and survival, a paracrine role of mammary adipose tissue being very likely in this process. In contrast to other adipose depots, occurrence of a sub-inflammatory state of mammary adipose tissue defined by dying adipocytes surrounded by macrophages forming crown-like structures ... -
Lipoprotein subfractions by nuclear magnetic resonance are associated with tumor characteristics in breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-08)<b>Background:</b> High-Density Lipoprotein (HDL)-cholesterol, has been associated with breast cancer development, but the association is under debate, and whether lipoprotein subfractions is associated with breast tumor characteristics remains unclear.<br> <b>Methods:</b> Among 56 women with newly diagnosed invasive breast cancer stage I/II, aged 35–75 years, pre-surgery overnight fasting serum ... -
Metabolite and lipoprotein responses and prediction of weight gain during breast cancer treatment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-07)<p><i>Background</i>: Breast cancer treatment has metabolic side effects, potentially affecting risk of cardiovascular disease (CVD) and recurrence. We aimed to compare alterations in serum metabolites and lipoproteins during treatment between recipients and non-recipients of chemotherapy, and describe metabolite profiles associated with treatment-related weight gain.</p> <p><i>Methods</i>: This ... -
Ny medikamentell behandling av brystkreft - Adjuvant behandling med trastuzumab ved tidlig stadium av brystkreft
(Research report; Forskningsrapport, 2006)Denne rapporten er første del av et oppdrag fra Sosial- og helsedirektoratet og RHF - fagdirektørene med fokus på effekt og bivirkninger av virkestoffet trastuzumab ved adjuvant behandling av brystkreft. Trastuzumab er ofte omtalt ved produktnavnet Herceptin. -
Ny medikamentell behandling av brystkreft Adjuvant behandling med trastuzumab ved tidlig stadium av brystkreft - en helseøkonomisk analyse
(Research report; Forskningsrapport, 2006)Denne rapporten er andre del av et oppdrag fra Sosial- og helsedirektoratet og RHF - fagdirektørene med fokus på virkestoffet trastuzumab ved adjuvant behandling av brystkreft. Adjuvant behandling gis i tillegg til hovedbehandlingen (for eksempel kirurgi) for å påvirke eventuelt gjenværende kreftceller hos pasienten. Denne delen av oppdraget vurderer de helseøkonomiske konsekvensene av adjuvant ... -
Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling estrogen and mammographic density phenotypes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-07)Background: Single nucleotide polymorphisms (SNPs) involved in the estrogen pathway and SNPs in the estrogen receptor alpha gene (ESR1 6q25) have been linked to breast cancer development, and mammographic density is an established breast cancer risk factor. Whether there is an association between daily estradiol levels, SNPs in ESR1 and premenopausal mammographic density phenotypes is unknown. Methods: ...
