Blar i forfatter Det helsevitenskapelige fakultet "Zhao, Lifen"

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    • Comprehensive N-glycan profiles of hepatocellular carcinoma reveal association of fucosylation with tumor progression and regulation of FUT8 by microRNAs 

      Cheng, Lei; Gao, Shuhang; Song, Xiaobo; Dong, Weijie; Zhou, Huimin; Zhao, Lifen; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Glycosylation has significant effects on cancer progression. Fucosylation is one of the most important glycosylation events involved in hepatocellular carcinoma (HCC). Here, we compared N-glycan profiles of liver tumor tissues and adjacent tissues of 27 HCC patients to reveal the association between fucosylation and HCC progression, as well as verified the potential role of miRNA in regulating ...

    • MiR-493-5p attenuates the invasiveness and tumorigenicity in human breast cancer by targeting FUT4 

      Zhao, Lifen; Feng, Xiaobin; Song, Xiaobo; Zhou, Humin; Zhao, Yongfu; Cheng, Lei; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-16)
      Breast cancer is a leading cause of cancer-related mortality among women. Altered fucosylation was found to be closely associated with tumorigenesis and metastasis of breast cancer. MicroRNAs (miRNAs) are important regulators of cell proliferation and metastasis, and aberrant miRNA expression has been observed in breast cancer. The present study aimed to evaluate the level of fucosyltransferase IV ...

    • Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia 

      Zhao, Lifen; Li, Yan; Song, Xiaobo; Zhou, Huimin; Li, Nana; Miao, Yuan; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Chemotherapy resistance frequently drives tumor progression. Increased expression of ST8SIA4 has been reported in diverse carcinomas and highly correlates with leukemia multidrug resistance (MDR). MicroRNAs (miRNA) are widely recognized as key players in cancer progression and drug resistance. Here, to explore whether miRNA modulates the sensitivity of chronic myelocytic leukemia (CML) to chemotherapeutic ...