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Serine-aspartate-repeat protein D Increases Staphylococcus aureus Virulence and Survival in Blood
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
Staphylococcus aureus expresses a panel of cell wall-anchored adhesins, including proteins belonging to the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) family, exemplified by the serine-aspartate repeat protein D (SdrD), which serve key roles in colonization and infection. Deletion of sdrD from S. aureus subsp. aureus strain NCTC8325-4 attenuated bacterial survival ...
Staphylococcus aureus Membrane-derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-20)
<i>Staphylococcus aureus</i> produces membrane-derived vesicles (MVs), which share functional properties to outer membrane vesicles. Atomic force microscopy revealed that <i>S. aureus</i>-derived MVs are associated with the bacterial surface or released into the surrounding environment depending on bacterial growth conditions. By using a comparative proteomic approach, a total of 131 and 617 proteins ...