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Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: A nested case-control study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-04)
Background:<br>Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.<br>Methods:<br>We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide ...
Measured adiposity in relation to head and neck cancer risk in the European prospective investigation into cancer and nutrition.
(Journal article; Tidsskriftartikkel, 2017-06)
<b>Background</b>: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error.<br><b>Methods</b>: Among 363,094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 ...
Circulating RANKL and RANKL/OPG and breast cancer risk by ER and PR subtype: Results from the EPIC cohort.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-31)
Receptor activator of nuclear factor-kappa B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer risk via activation of RANK signaling; this may be modulated by osteoprotegerin (OPG), the decoy receptor for RANKL. sRANKL and breast cancer risk by hormone receptor subtype has ...
Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, ...
Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-19)
Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: A cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-07)
Background: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body
fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for
cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations
measured using an index score (the WCRF/AICR score) was associated with ...
Combined impact of healthy lifestyle factors on colorectal cancer: A large European cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-05)
The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.
Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. ...
Consumption of dairy products and colorectal cancer in the European prospective investigation into cancer and nutrition (EPIC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background: Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of
total dairy products, total milk and dietary calcium. However, less is known about whether the inverse associations vary for
individual dairy products with differing fat contents.
Materials and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), ...
One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)
Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case–control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre‐diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell ...