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Joint effects of cancer and variants in the factor 5 gene on the risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09)
Venous thromboembolism occurs frequently in cancer patients. Two variants in the factor 5 gene (F5), rs6025 encoding for the factor V Leiden mutation R506Q, and rs4524 encoding K858R, have been found to be associated with venous thromboembolism. We assessed the joint effect of active cancer and these two F5 variants on venous thromboembolism risk in a case-cohort study. Cases with a first venous ...