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Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p21–6p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we ...
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)
<i>Background</i>: Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE).<p>
<p><i>Objectives</i>: To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case‐cohort recruited from a general population.<p>
<p><i>Methods</i>: Cases with a first VTE (<i>n</i> = 1493) and a subcohort (<i>n</i> = ...