Search
Now showing items 1-10 of 16
Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-16)
Purpose: <br>Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be
involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective
studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting
results.<br>
Methods: <br>We pooled and harmonized data from 6 case-control studies nested within the
Ovarian Cancer ...
Multiple miscarriages are associated with the risk of ovarian cancer: results from the European prospective investigation into cancer and nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
While the risk of ovarian cancer clearly reduces with each full-term pregnancy, the effect of incomplete pregnancies is unclear. We investigated whether incomplete pregnancies (miscarriages and induced abortions) are associated with risk of epithelial ovarian cancer. This observational study was carried out in female participants of the European Prospective Investigation into Cancer and Nutrition ...
Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-20)
Background:
Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women,
limiting their utility for screening.
<br>Methods:
We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers
among controls (
n
= 1910) from a nested case-control study in the European Prospective Investigation into
Cancer and Nutrition ...
Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-18)
Development and validation of circulating CA125 prediction models in postmenopausal women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-26)
<i>Background</i>
- Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.<p><p>
<i>Methods</i>
- We developed and validated ...
Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-30)
Background: Reproductive events are associated with important physiologic changes, yet little is known about
how reproductive factors influence long-term health in women. Our objective was to assess the relation of reproductive
characteristics with all-cause and cause-specific mortality risk.
<p>Methods: The analysis was performed within the European Investigation into Cancer and Nutrition ...
Androgens are differentially associated with ovarian cancer subtypes in the Ovarian Cancer Cohort Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-05)
Invasive epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. Research on pre-diagnosis androgen concentrations and EOC risk has yielded inconclusive ...
Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-04)
Despite some epidemiological evidence on the protective effects of polyphenol intake on
epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective
studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the
associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a
large ...
Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-03)
A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC ...
High levels of C-reactive protein are associated with an increased risk of ovarian cancer: Results from the Ovarian Cancer Cohort Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-28)
Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient characteristics has not been adequately explored. In this study, we pooled data from ...