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Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes
(Journal article; Tidsskriftartikkel; Manuskript; Peer reviewed; Preprint, 2017-04-10)
Intravenously injected nanopharmaceuticals, including PEGylated nanoparticles, induce adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are highly reproducible in pigs. Although the underlying mechanisms are poorly understood, roles for both the complement system and reactive macrophages have been implicated. Here, we show the dominance and importance of robust ...