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Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-16)
Purpose: <br>Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be
involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective
studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting
results.<br>
Methods: <br>We pooled and harmonized data from 6 case-control studies nested within the
Ovarian Cancer ...
Osteoprotegerin and breast cancer risk by hormone receptor subtype: A nested case-control study in the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-08)
Background:<br>Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study.<br>Methods:<br>A case-control ...
Circulating RANKL and RANKL/OPG and breast cancer risk by ER and PR subtype: Results from the EPIC cohort.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-31)
Receptor activator of nuclear factor-kappa B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer risk via activation of RANK signaling; this may be modulated by osteoprotegerin (OPG), the decoy receptor for RANKL. sRANKL and breast cancer risk by hormone receptor subtype has ...
Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-20)
Background:
Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women,
limiting their utility for screening.
<br>Methods:
We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers
among controls (
n
= 1910) from a nested case-control study in the European Prospective Investigation into
Cancer and Nutrition ...
Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-11)
Previous case–control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included ...
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-05)
The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.
Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. ...
Development and validation of circulating CA125 prediction models in postmenopausal women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-26)
<i>Background</i>
- Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.<p><p>
<i>Methods</i>
- We developed and validated ...
Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-03)
Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the ...
Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-03)
A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC ...
An epidemiologic risk prediction model for ovarian cancer in Europe: The EPIC study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-05)
Background: Ovarian cancer has a high case-fatality ratio, largely due to late diagnosis. Epidemiologic risk prediction models could help identify
women at increased risk who may benefit from targeted prevention measures, such as screening or chemopreventive agents.<p>
<p>Methods: We built an ovarian cancer risk prediction model with epidemiologic risk factors from 202 206 women in the European ...