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Temporal trends in incidence and case fatality of intracerebral hemorrhage. The Tromsø Study 1995-2012
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-16)
<p>Background: The aim of this study was to explore temporal trends in incidence and case fatality rates of intracerebral hemorrhage (ICH) over the last two decades in a Norwegian municipality.
<p>Methods: Incident cases of primary ICH were registered in the period from 1995 through 2012 in 32,530 par ticipants of the longitudinal population-based Tromsø Study. Poisson regression models were used ...
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-23)
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, ...
Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)
<i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and
venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using
time-fixed analyses without and with correction for regression dilution and time-varying
analyses.<p>
<p><i>Methods:</i> ...
Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-07)
<i>Background</i> - Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the
strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate
the association between ischemic stroke and VTE in a prospective population-based cohort.<p>
<p><i>Methods and Results</i> - Participants (n=30 ...
HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confoundersin a meta-analysis of individual participant data from six cohort studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-11)
Background:<br>To determine the shape of the associations of HbA1c with mortality and cardiovascular outcomes in
non-diabetic individuals and explore potential explanations.<br>
Methods:<br> The associations of HbA1c with all-cause mortality, cardiovascular mortality and primary cardiovascular
events (myocardial infarction or stroke) were assessed in non-diabetic subjects ≥50 years from six ...
Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)
Background: Recent studies have demonstrated an association between venous thromboembolism (VTE) and arterial thrombotic diseases.
<p> Objectives: We aimed to study the association between incident myocardial infarction (MI) and VTE in a prospective population-based cohort.
<p> Methods: Study participants (n=29 506) were recruited from three surveys of the Tromsø Study (conducted in 1994-95, 2001-02 ...
Associations between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-21)
Background—Genetic variation can be used to study causal relationships between biomarkers and diseases. Here, we
identify new common and rare genetic variants associated with cardiovascular-related protein levels (protein quantitative
trait loci [pQTLs]). We functionally annotate these pQTLs, predict and experimentally confirm a novel molecular
interaction, and determine which pQTLs are associated ...