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DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-28)
Aim of the study: A vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing, known as ‘epigenetic clock’, has been linked with cancer risk factors. This study aimed to evaluate whether the epigenetic clock is associated with breast cancer risk susceptibility and to identify potential epigenetics-based ...
The premenopausal breast cancer collaboration: A pooling project of studies participating in the national cancer institute cohort consortium
(Journal article; Tidsskriftartikkel, 2017-09)
Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence rates of advanced breast cancer have increased in recent decades for premenopausal women. Progress in identifying contributors to breast cancer risk among premenopausal women has been constrained by the limited numbers of premenopausal breast cancer cases in individual ...