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Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-20)
Background:
Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women,
limiting their utility for screening.
<br>Methods:
We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers
among controls (
n
= 1910) from a nested case-control study in the European Prospective Investigation into
Cancer and Nutrition ...
Prospective analysis of circulating metabolites and breast cancer in EPIC
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-24)
<i>Background</i> - Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk.<p>
<p><i>Methods</i> - A nested case-control study was established within the European Prospective Investigation into Cancer cohort, which ...
Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-04)
Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive.
Data suggest risk associations vary by tumour characteristics.<p>
<p>Methods: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
to evaluate IGF-I concentrations and EOC risk by tumour characteristics ...