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Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke 

Hald, Erin Mathiesen; Rinde, Ludvig Balteskard; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)
<p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> ...
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Atrial fibrillation is associated with cognitive decline in stroke-free subjects: the Tromsø Study 

Tiwari, Sweta; Løchen, Maja-Lisa; Jacobsen, Bjarne K.; Hopstock, Laila Arnesdatter; Nyrnes, Audhild; Njølstad, Inger; Mathiesen, Ellisiv B.; Arntzen, Kjell Arne; Ball, Jocasta; Stewart, Simon; Wilsgaard, Tom; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-28)
Background and purpose:<br>Previous studies have shown associations between atrial fibrillation (AF) and cognitive decline. We investigated this association in a prospective population study, focusing on whether stroke risk factors modulated this association in stroke-free women and men.<br>Methods:<br>We included 4983 participants (57% women) from the fifth survey of the Tromsø Study (Tromsø 5, ...
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Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study 

Ball, Jocasta; Løchen, Maja-Lisa; Wilsgaard, Tom; Schirmer, Henrik; Hopstock, Laila Arnesdatter; Morseth, Bente; Mathiesen, Ellisiv B.; Njølstad, Inger; Tiwari, Sweta; Sharashova, Ekaterina (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-19)
<p><i>Background</i>: Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated.</p> <p><i>Methods and Results</i>: Data from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF ...
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The metabolic syndrome and progression of carotid atherosclerosis over 13 years. The Tromsø study. 

Herder, Marit; Arntzen, Kjell Arne; Johnsen, Stein Harald; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
The metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease. In this study, we examine if metabolic syndrome predicts progression of atherosclerosis over 13 years. Participants were 1442 men and 1532 women in the population-based Tromsø Study who underwent carotid ultrasound examinations at baseline in the 4th (1994–5) and at follow-up in the 6th survey (2007–8). Of ...
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Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study 

Jorde, Rolf; Schirmer, Henrik; Wilsgaard, Tom; Joakimsen, Ragnar Martin; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; Figenschau, Yngve; Berg, Jens Petter; Svartberg, Johan; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these ...
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Cohort profile: The Tromsø Study 

Jacobsen, Bjarne Koster; Eggen, Anne Elise; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
The Tromsø Study was initiated in 1974 in an attempt to help combat the high mortality of cardiovascular diseases in Norway, that was particularly pronounced among middle-aged men. In the mid-1970s, Norwegian men had a 20% risk of dying of myocardial infarction (MI) before the age of 75 years. The situation in Northern Norway was even worse.1 The primary aim of the Tromsø Study was to determine ...
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Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994-2013 

Norvik, Jon Viljar; Schirmer, Henrik; Ytrehus, Kirsti; Storhaug, Hilde-Merete; Jenssen, Trond Geir; Eriksen, Bjørn Odvar; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Wilsgaard, Tom; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-31)
Aims: To investigate whether serum uric acid predicts adverse outcomes in persons with indices of diastolic dysfunction in a general population. <br>Methods and results: We performed a prospective cohort study among 1460 women and 1480 men from 1994 to 2013. End- points were all-cause mortality, incident myocardial infarction, and incident ischaemic stroke. We strati fi ed the analyses ...
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Temporal trends in incidence and case fatality of intracerebral hemorrhage. The Tromsø Study 1995-2012 

Carlsson, Maria; Wilsgaard, Tom; Johnsen, Stein Harald; Vangen-Lønne, Anne Merete; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-16)
<p>Background: The aim of this study was to explore temporal trends in incidence and case fatality rates of intracerebral hemorrhage (ICH) over the last two decades in a Norwegian municipality. <p>Methods: Incident cases of primary ICH were registered in the period from 1995 through 2012 in 32,530 par ticipants of the longitudinal population-based Tromsø Study. Poisson regression models were used ...
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Does insomnia modify the association between C-reactive protein and migraine? The Tromsø Study 2015-2016. 

Hagen, Knut; Hopstock, Laila Arnesdatter; Eggen, Anne Elise; Mathiesen, Ellisiv B.; Nilsen, Kristian Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-12)
<p><i>Background - </i>The relationship between high sensitivity C-reactive protein and migraine is unclear. The aim of this cross-sectional population-based study was to investigate the association between high sensitivity C-reactive protein and types of headache, and to evaluate the impact of insomnia on this association. <p><i>Methods - </i>A total of 20,486 (63%) out of 32,591 invited, aged ≥40 ...
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Association of occasional smoking with total mortality in the population-based Tromsø study, 2001-2015 

Løchen, Maja-Lisa; Gram, Inger Torhild; Mannsverk, Jan T.; Mathiesen, Ellisiv B.; Njølstad, Inger; Schirmer, Henrik; Wilsgaard, Tom; Jacobsen, Bjarne K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)
Objectives: <br> There is a shift in the smoking population from daily smokers to light or occasional smokers. The knowledge about possible adverse health effects of this new smoking pattern is limited. We investigated smoking habits with focus on occasional smoking in relation to total mortality in a follow-up study of a Norwegian general population. <br> Setting: <br> A population study ...
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