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Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
Measurements of serum prostate-specific antigen (PSA) protein levels form the basis for a widely used test to screen men for prostate cancer. Germline variants in the gene that encodes the PSA protein (KLK3) have been shown to be associated with both serum PSA levels and prostate cancer. Based on a resequencing analysis of a 56 kb region on chromosome 19q13.33, centered on the KLK3 gene, we fine ...
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
Many incident cases of type 2 diabetes do not
fulfill the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic
score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, and ...
Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
Complex trait genome-wide association studies (GWAS) provide an efficient strategy for evaluating large numbers of common variants in large numbers of individuals and for identifying trait-associated variants. Nevertheless, GWAS often leave much of the trait heritability unexplained. We hypothesized that some of this unexplained heritability might be due to common and rare variants that reside in ...
Impaired Fasting Glucose Is Associated With Renal Hyperfiltration in the General Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration in individuals without diabetes are largely unknown, including the possible role of borderline hyperglycemia. We assessed whether impaired fasting glucose (IFG; 5.6–6.9 mmol/L), elevated HbA1c, or hyperinsulinemia are associated with hyperfiltration ...
Comparative effectiveness of antihypertensive medication of primary prevention of cardiovascular disease : systematic review and multiple treatments meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
We conducted a systematic review of evidence from randomized controlled trials to answer the following research question: What are the relative effects of different classes of antihypertensive drugs in reducing the incidence of cardiovascular disease outcomes for healthy people at risk of cardiovascular disease?
We searched MEDLINE, EMBASE, AMED (up to February 2011) and CENTRAL (up to May 2009), ...
Incidence of and risk factors for type-2 diabetes in a general population: The Tromso Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but
conflicting results have been reported on its role in venous thromboembolic disease. The objective of our study was to investigate the association between high-sensitivity C-reactive protein levels and risk of future venous thromboembolism in a prospective cohort recruited from a general population. ...
Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism - The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Obesity measures and risk of venous thromboembolism and myocardial infarction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Venous thromboembolism increases the risk of atrial fibrillation: The tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)