We performed randomized controlled experimental studies in an intact animal model and in isolated cardiac myocytes with the following aims: To establish an in vivo model for measuring cardiac intracellular [Ca2+] ([Ca2+]i) in an anesthetized rat with maintained spontaneous circulation. In this model we could sort out if alterations in Ca2+ homeostasis take place in response to hypothermia and ...

This thesis is based on four papers that have imaging techniques used in breast reconstruction as the common denominator. Each paper describes the results of a study. The purpose of the first three studies was to evaluate the use of dynamic infrared thermography (DIRT) as an imaging technique for perforator mapping in breast reconstruction with a deep inferior epigastric perforator (DIEP) flap. The ...

Wild rats employ a rather extensive area for their daily activities and share elaborate burrows with tunnel and chambers. When a female enters estrus, she will copulate with multiple males during the entire period of estrus. In a typical laboratory setting, rat sexual behavior is studied in pairs of opposite sex individuals. Apparently the experimental studies have been performed in this highly ...

I helseinstitusjoner vancomycin-resistente enterokokker en fryktet bakterie som kan lage alvorlig infeksjonssykdom i pasienter med dårlig immunforsvar, og er vanskelig å behandle. Avhandlingen fokuserer på vancomycin-resistente enterokokker (VRE), og hvordan disse bakteriene gjennom å overføre gener mellom hverandre kan utvikle resistens mot antibiotika. Vi har analysert to utbrudd av VRE i Sverige ...

Acute heart failure (AHF) is a disease with a mortality ranging from 5 to 40% depending on severity, despite modern revascularization techniques after acute myocardial thromboembolism. In this thesis we have investigated two new concepts of treating AHF. In paper 1 we investigated the combination of dobutamine and ivabradine (D+I) in a porcine model of stunning AHF. Ivabradine attenuated the ...

<i>Background and aim</i>: High prevalence of childhood overweight/obesity is a major health concern due to related immediate and long-term health problems. Early identification of children at risk is of interest, as preventing or delaying the onset of obesity may influence future health. The aim of this thesis was to study how early life factors such as birth weight, childhood body mass index (BMI, ...

The current vision of healthcare is evolving in directions towards the secondary use of health data for producing new evidence, rapidly assimilating new knowledge, including the patient as an active component in decision-making and developing communication strategies to coordinate different areas of health care, among others. The work in these directions heavily relies on the appropriate use of ...

We performed randomized, controlled experimental studies in an intact rat model and in isolated rat cardiomyocytes with the following aims: Paper I: To investigate the effects of epinephrine during hypothermia and after rewarming and determine hypothermia-induced effects on in vivo and in vitro cardiac β-receptor sensitivity. Paper II: To describe hemodynamic responses to the phosphodiesterase ...

The physiological effects of transcranial direct current stimulation (tDCS) in the living human brain were verified experimentally in the early 2000's. A series of studies from Göttingen, Germany, shows that consistently, anodal stimulation lead to increased cortical excitability, while cathodal stimulation leads to increased cortical inhibition. Since then, the effect of tDCS has been further ...