Now showing items 1-10 of 598
Hypothermia-induced myocardial calcium overload –a study of intracellular Ca2+ handling during profound hypothermia and rewarming
(Doctoral thesis; Doktorgradsavhandling, 2016-09-30)
We performed randomized controlled experimental studies in an intact animal model and in isolated cardiac myocytes with the following aims: To establish an in vivo model for measuring cardiac intracellular [Ca2+] ([Ca2+]i) in an anesthetized rat with maintained spontaneous circulation. In this model we could sort out if alterations in Ca2+ homeostasis take place in response to hypothermia and ...
Interpretation of forearm bone mineral density : the Tromsø study
(Doctoral thesis; Doktorgradsavhandling, 2000)
Imaging in plastic surgery. A clinical and experimental study with notes on the history of medical imaging.
(Doctoral thesis; Doktorgradsavhandling, 2013-04-29)
This thesis is based on four papers that have imaging techniques used in breast reconstruction as the common denominator. Each paper describes the results of a study. The purpose of the first three studies was to evaluate the use of dynamic infrared thermography (DIRT) as an imaging technique for perforator mapping in breast reconstruction with a deep inferior epigastric perforator (DIEP) flap. The ...
Potato consumption and risk of colorectal and pancreatic cancer. The Norwegian Women and Cancer cohort and the HELGA cohort.
(Doctoral thesis; Doktorgradsavhandling, 2016-10-14)
Summary The present work includes participants from two cohorts: The Norwegian Women and Cancer (NOWAC) study (paper 1 and 2) and the HELGA study (paper 3). The NOWAC Study is a population-based prospective cohort study that started data collection in 1991, and consists of more than 172,000 women. The HELGA study is a population-based Scandinavian cohort, consisting of 119,978 men and women from: ...
Sociosexual behaviors and reproductive success in a group of rats housed in seminatural environment
(Doctoral thesis; Doktorgradsavhandling, 2015-04-20)
Wild rats employ a rather extensive area for their daily activities and share elaborate burrows with tunnel and chambers. When a female enters estrus, she will copulate with multiple males during the entire period of estrus. In a typical laboratory setting, rat sexual behavior is studied in pairs of opposite sex individuals. Apparently the experimental studies have been performed in this highly ...
Mobile genetic elements causing plasticity in E. faecium
(Doctoral thesis; Doktorgradsavhandling, 2017-03-24)
I helseinstitusjoner vancomycin-resistente enterokokker en fryktet bakterie som kan lage alvorlig infeksjonssykdom i pasienter med dårlig immunforsvar, og er vanskelig å behandle. Avhandlingen fokuserer på vancomycin-resistente enterokokker (VRE), og hvordan disse bakteriene gjennom å overføre gener mellom hverandre kan utvikle resistens mot antibiotika. Vi har analysert to utbrudd av VRE i Sverige ...
Novel inotropic strategies for treating acute heart failure: A large animal study on cardiac function and energetics
(Doctoral thesis; Doktorgradsavhandling, 2017-02-16)
Acute heart failure (AHF) is a disease with a mortality ranging from 5 to 40% depending on severity, despite modern revascularization techniques after acute myocardial thromboembolism. In this thesis we have investigated two new concepts of treating AHF. In paper 1 we investigated the combination of dobutamine and ivabradine (D+I) in a porcine model of stunning AHF. Ivabradine attenuated the ...
Psoriasis, overweight and metabolic syndrome. The Tromsø Study
(Doctoral thesis; Doktorgradsavhandling, 2014-05-28)
Recently it has been suggested that the chronic inflammatory disease psoriasis is more than skin deep, as it has been associated with several comorbid conditions, including diabetes and cardiovascular disease. Increasing prevalence of psoriasis has been observed, possibly due to changes in lifestyle. Within the population-based Tromsø study cohort, we found an increase in the self-reported prevalence ...
Overweight/obesity, body composition and bone mass in late adolescence: the relation with birth weight, childhood body mass index and growth. The Tromsø Study: Fit Futures, a longitudinal cohort study
(Doctoral thesis; Doktorgradsavhandling, 2019-02-07)
<i>Background and aim</i>: High prevalence of childhood overweight/obesity is a major health concern due to related immediate and long-term health problems. Early identification of children at risk is of interest, as preventing or delaying the onset of obesity may influence future health. The aim of this thesis was to study how early life factors such as birth weight, childhood body mass index (BMI, ...
Managing exacerbations of chronic obstructive pulmonary disease - An investigation of treatment decisions from a primary care perspective
(Doctoral thesis; Doktorgradsavhandling, 2017-03-24)
Exacerbations of chronic obstructive pulmonary disease (COPD) compose a considerable burden for both patients and health care systems. Optimal management in primary care, including self-treatment of COPD exacerbations with antibiotics and oral corticosteroids, is considered to be one key for providing good care for patients at reasonable costs. This thesis aimed to explore treatment of COPD exacerbations ...