Viser treff 1-10 av 396
Gene expression profile of normal and compromised placentas
(Doctoral thesis; Doktorgradsavhandling, 2009-06-26)
<b>Objective</b> <br>Placenta has an important function of sustaining life in utero. Role of placental gene expression in the physiology of parturition and pathogenesis of pregnancy disorders are poorly understood. The aims of this thesis were to: <br>1. Investigate the effect of labor on global gene expression profile of normal placentas <br>2. Compare placental gene expression profile of ...
Pattern recognition receptors in liver sinusoidal endothelial cells : Roles in the innate immune system and scavenger functions
(Doctoral thesis; Doktorgradsavhandling, 2011-05-05)
Effective removal of unwanted self and non-self molecules from blood is essential to keep the organism healthy. Liver sinusoidal endothelial cells (LSECs) have been shown to effectively clear such macromolecules via receptor-mediated endocytosis. The cells express several high affinity endocytosis receptors, including the mannose receptor (MR), and several scavenger receptors (SRs), which are known ...
A genetic spectrum approach to affective and schizophrenic disorders : a twin- and family study
(Doctoral thesis; Doktorgradsavhandling, 2009-09-15)
Over 300 eneggete- og toeggete tvillingpar rekruttert fra sykehusarkiv, og deres 1.grads slektninger (foreldre og søsken), ble intervjuet personlig og diagnostisert i henhold til moderne diagnostiske systemer (DSM-III-R) både med hensyn til symptomforstyrrelser (Akse I), og personlighetsforstyrrelser (Akse II). De ble også intervjuet angående forhold knyttet til tvillingenes fødsel og oppvekst. ...
Size characterisation of liposomes using asymmetrical flow field-flow fractionation : factors influencing fractionation and size determination
(Doctoral thesis; Doktorgradsavhandling, 2009-08-27)
Liposomes play an important role in medical and pharmaceutical science as e.g. nanoscale drug carriers. One of their most important features is their size and size distribution, influencing both their biodistribution and passive targeting abilities upon intravenous administration. To this day there is no single method for size characterisation of liposomes that fulfils all following criteria: being ...
Fetal cardiac output and its distribution to the placenta and brain at 11-20 weeks of gestation
(Doctoral thesis; Doktorgradsavhandling, 2009-09-11)
Objective: To study some aspects of fetal heart structure and function using ultrasonography at 11-20 weeks of gestation with an emphasis on the distribution of cardiac output to the placenta and upper body including brain. <br> Methods: In a cross-sectional study of unselected pregnant population, the structure of the fetal heart was studied using transvaginal ultrasonography and feasibility ...
Advanced Non-small Cell Lung Cancer Effects of Chemotherapy and Impact on Health Related Quality of Life
(Doctoral thesis; Doktorgradsavhandling, 2009-03-13)
Avhandlingen presenterer behandlingseffekt, bivirkninger og livskvalitet hos lungekreftpasienter som får moderne cellegiftbehandling. Pasientene med performance status (PS) 2 er etterpå vurdert separat. <br><br>Avhandlingens tittel er ”Advanced non-small cell Lung Cancer – Effects of Chemotherapy and Impact on Health Related Quality of Life”. Den ble forsvart for graden PhD 13.03.2009. På verdensbasis ...
Local public health physicians in Norway from 1994 to 2002 : workload, work content, and interaction : a story of everyday life in primary health care
(Doctoral thesis; Doktorgradsavhandling, 2008-03-07)
Avhandlingens tema er utviklingen innenfor lokal samfunnsmedisinsk legetjeneste fra 1994 til 2002. Desentraliserings- og liberaliseringsreformer i primærhelsetjenesten, endringer i helseforhold og etterspørsel etter helsetjenester endret arbeidsarenaen for samfunnsmedisinerne, og gav økonomiske, organisatoriske og faglige utfordringer. Avhandlingen er basert på tre tverrsnittsundersøkelser, gjennom ...
Health education and self care in dentistry : surveys and interventions.
(Doctoral thesis; Doktorgradsavhandling, 1989)
The role of the estrogen receptor α in the medial amygdala and the ventromedial nucleus of the hypothalamus in sexual motivation, social recognition, aggression and anxiety
(Doctoral thesis; Doktorgradsavhandling, 2010-09-01)
Estrogens have been shown to be implicated not only in sexual behaviors but also in several cognitive functions, social behaviors, and emotional reactions. Estrogen receptors mediate estrogen actions in the brain and the estrogen receptor α (ERα) has attracted some attention. Although the display of female sexual motivation and copulatory behaviors require estrogens, their sites of action in brain ...
Personality characteristics and vulnerability to depression : a cross-sectional and longitudinal perspective
(Doctoral thesis; Doktorgradsavhandling, 2009-12-04)
Depression is a serious disorder due to its highly relapsing and recurrent course, thereby highlighting the necessity to identify vulnerability factors in order to prevent and treat its course. The present thesis investigated temperament and character traits, dysfunctional attitudes, and early maladaptive schemas (EMSs) in clinically depressed (CDs), previously depressed (PDs), and never depressed ...