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Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: Combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-29)
Background: The chemokine CXCL16 and its receptor CXCR6 are expressed by a variety of immune cells and have been shown to influence angiogenesis. The expression of CXCR6 and CXCL16 has been examined in numerous human cancers; however no studies have yet investigated their influence on prognosis in non-small cell lung cancer (NSCLC). We aimed to explore their prognostic significance in NSCLC, in ...
Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival
(Master thesis; Mastergradsoppgave, 2015-10-27)
BACKGROUND: The chemokine CXCL16 and its receptor CXCR6 are expressed by a variety of immune cells and have been shown to influence angiogenesis. The expression of CXCR6 and CXCL16 has been examined in numerous human cancers; however no studies have yet investigated their influence on prognosis in non-small cell lung cancer (NSCLC). We aimed to explore their prognostic significance in NSCLC, in ...
Lymphangiogenic Markers and Their Impact on Nodal Metastasis and Survival in Non-Small Cell Lung Cancer--A Structured Review with Meta-Analysis.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-25)
Background
In non-small cell lung cancer (NSCLC), nodal metastasis is an adverse prognostic factor.
Several mediating factors have been implied in the development of nodal metastases and
investigated for predictive and prognostic properties in NSCLC. However, study results differ.
In this structured review and meta-analysis we explore the published literature on commonly
recognized pathways for ...
Cancer associated fibroblasts in stage I-IIIA NSCLC: Prognostic impact and their correlations with tumor molecular markers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-07)
Background
Cancer Associated Fibroblasts (CAFs) are thought to regulate tumor growth and metastasis.
Fibroblast Activating Protein 1 (FAP-1) is a marker for fibroblast activation and by many
recognized as the main marker of CAFs. Alpha Smooth Muscle Actin (α-SMA) is a general
myofibroblast marker, and can be used to identify CAFs. This study investigates the prognostic
impact of FAP-1 and α-SMA ...
High progesterone receptor expression in prostate cancer is associated with clinical failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-27)
Background
Prostate cancer is a highly heterogeneous disease and one of the leading causes of mortality
in developed countries. Specific prognostic and predictive markers for prostate cancer
patients are still lacking. A causal relationship between androgens and the development of
prostate cancer is generally considered biologically plausible, but androgens are not the
sole effector in the ...
CD45RO+ Memory T Lymphocytes – a Candidate Marker for TNM-Immunoscore in Squamous Non-Small Cell Lung Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
Tumor-infiltrating lymphocytes (TILs) are vital in limiting cancer progression and may supplement the TNM classification.
CD45RO+ memory TILs show major prognostic impact in various malignancies but have not been extensively explored in
non–small cell lung cancer (NSCLC). In this study, we aimed to evaluate their potential in a NSCLC TNM-Immunoscore.
Tissue microarrays were constructed from tumor ...