Søk
Viser treff 1-4 av 4
Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-07)
Objectives: <br>
Selective targeting of cancer-associated fibroblasts (CAFs) has been proposed to synergize
with immune-checkpoint inhibitors. While the roles of CAFs in cancer development are well
described, their immune-regulatory properties remain incompletely understood. This study
investigates correlations between CAF and immune-markers in tumor stroma from nonsmall
cell lung cancer (NSCLC) ...
A gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-04)
Micro RNAs (miRNA) are small non-coding RNAs that post-transcriptionally regulate gene expression. Dysregulation of miRNA cluster 143/145 has been reported in several malignancies, but their role in non-small cell lung cancer (NSCLC) remains elusive. This study investigates the prognostic impact of miR-143 and miR-145 in primary tumors and metastatic lymph nodes in NSCLC tissue. Tissue from 553 ...
Progesterone receptors in prostate cancer: Progesterone receptor B is the isoform associated with disease progression
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-27)
The role of steroid hormones in carcinogenesis of the prostate is to some extent unraveled thorough the effect of androgen deprivation therapy on prostate cancer (PCa) progression. Other members of the steroid hormone family, such as progesterone, are also implicated in PCa, but progesterone’s role remains undefined. This study aimed to examine the distribution of progesterone receptor isoforms ...
Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
Lung cancer is the leading cause of cancer deaths. Novel predictive biomarkers are needed to improve treatment selection and more accurate prognostication. PAX6 is a transcription factor with a proposed tumour suppressor function. Immunohistochemical staining was performed on tissue microarrays from 335 non-small cell lung cancer (NSCLC) patients for PAX6. Multivariate analyses of clinico-pathological ...