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Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)
<i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and
venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using
time-fixed analyses without and with correction for regression dilution and time-varying
analyses.<p>
<p><i>Methods:</i> ...
Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-10)
Red cell distribution width (RDW), a measure of variability in size of circulating
erythrocytes, is associated with arterial cardiovascular disease (CVD), but the
underlying mechanism remains unclear. We aimed to investigate the impact of
chronic inflammation as measured by high sensitivity CRP (hs-CRP) on this
relationship, and explore whether RDW could be a mediator in the causal pathway
between ...
Dietary intake of marine n-3 polyunsaturated fatty acids and future risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
<p><i>Background</i>: Studies on the association between long‐chained n‐3 polyunsaturated fatty acids (n‐3 PUFAs) and risk of venous thromboembolism (VTE) are conflicting, potentially due to challenges related to assessment of n‐3 PUFA intake and changes in diet during follow‐up.</p>
<p><i>Objectives</i>: To investigate whether dietary intake of marine n‐3 PUFAs was associated with risk of incident ...
The Role of Stroke as a Trigger for Incident Venous Thromboembolism: Results from a Population-based Case-Crossover Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-22)
Stroke is associated with a short-term increased risk of subsequent venous thromboembolism (VTE). It is unclear to what extent this association is mediated by strokerelated complications that are potential triggers for VTE, such as immobilization and
infection. We aimed to investigate the role of acute stroke as a trigger for incident VTE
while taking other concomitant VTE triggers into account. ...
Prothrombotic genotypes and risk of major bleeding in patients with incident venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-22)
<i>Background</i> - Genotypes associated with venous thromboembolism (VTE) may protect against bleeding due to a hypercoagulable state. Whether the risk of major bleeding is reduced in parallel with an increasing number of prothrombotic genotypes during anticoagulant treatment in VTE remains unknown.<p>
<p><i>Objectives</i> - To investigate the association between multiple prothrombotic genotypes ...
Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-15)
Growth differentiation factor 15 (GDF-15), a marker of inflammation and oxidative stress, has emerged as a biomarker for arterial cardiovascular disease. However, the association between GDF-15 and venous thromboembolism (VTE) remains uncertain. We therefore investigated the association between plasma GDF-15 levels and future risk of incident VTE and explored the potential of a causal association ...
Repeated assessments of physical activity and risk of incident venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-06)
<p><i>Background</i>: Whether physical activity influences the risk of incident venous thromboembolism (VTE) remains controversial, potentially because of methodological challenges, such as regression dilution bias.</p>
<p><i>Objectives</i>: To investigate whether physical activity was associated with VTE risk, and explore the role of body mass index (BMI) as a mediator in a population‐based ...
Joint effects of cancer and variants in the factor 5 gene on the risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09)
Venous thromboembolism occurs frequently in cancer patients. Two variants in the factor 5 gene (F5), rs6025 encoding for the factor V Leiden mutation R506Q, and rs4524 encoding K858R, have been found to be associated with venous thromboembolism. We assessed the joint effect of active cancer and these two F5 variants on venous thromboembolism risk in a case-cohort study. Cases with a first venous ...
Long-Term Incidence of Venous Thromboembolism in Cancer: The Scandinavian Thrombosis and Cancer Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-06)
The risk of venous thromboembolism (VTE) in patients who survive the first years after a cancer diagnosis after the acute effects of disease and treatment in comparison to a similar background population has been sparsely investigated. The aim of the study was to investigate if incidence rates (IRs) of VTE differed in patients who were alive at least 2 years after a cancer diagnosis without VTE ...
Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
The role of complement in the pathogenesis of venous thromboembolism (VTE) is unclear. We wanted to investigate (1) whether plasma complement component C5 (C5) levels are influenced by genetic variants or chronic inflammation and (2) the association between plasma C5 and risk of future VTE in a nested case-control study of 415 patients with VTE and 848 age- and sex-matched controls derived from the ...