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Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study 

Joseph, Josepha; Svartberg, Johan; Njølstad, Inger; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
Many incident cases of type 2 diabetes do not fulfill the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, and ...
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Incidence of and risk factors for type-2 diabetes in a general population: The Tromso Study 

Joseph, Josepha; Svartberg, Johan; Njølstad, Inger; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
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Association between diastolic dysfunction and future atrial fibrillation in the Tromsø Study from 1994 to 2010 

Tiwari, Sweta; Schirmer, Henrik; Jacobsen, Bjarne K.; Hopstock, Laila Arnesdatter; Nyrnes, Audhild; Heggelund, Geir; Njølstad, Inger; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-13)
Objective. To investigate the association between echocardiographic measurements with emphasis on diastolic dysfunction and risk of atrial fibrillation (AF) in a population-based cohort study. Methods. We followed 2406 participants from the Tromsø Study from 1994 to 2010. Left atrial (LA) size and mitral Doppler indices as measured by echocardiography were used for evaluating diastolic dysfunction. ...
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Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study 

Jorde, Rolf; Schirmer, Henrik; Wilsgaard, Tom; Joakimsen, Ragnar Martin; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; Figenschau, Yngve; Berg, Jens Petter; Svartberg, Johan; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these ...
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Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromso OGTT Study 

Hutchinson, Moira Strand; Joakimsen, Ragnar Martin; Njølstad, Inger; Schirmer, Henrik; Figenschau, Yngve Anton; Svartberg, Johan; Jorde, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Hb 6.5% has recently been recommended as an alternative diagnostic criterion for diabetes. The aims of the study were to evaluate the effects of age, sex, and other factors on prevalence of diabetes and to compare risk profiles of subjects with diabetes when defined by Hb and glucose criteria. Subjects were recruited among participants in the longitudinal population-based Tromsø Study. Hb , fasting ...
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Genetic variations in the Vitamin D receptor predict type 2 diabetes and myocardial infarction in a community-based population: The tromsø study 

Zostautiene, Leva; Jorde, Rolf; Schirmer, Henrik; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; Wilsgaard, Tom; Joakimsen, Ragnar Martin; Kamycheva, Elena (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-23)
Background Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism (SNP) of the vitamin D receptor ...
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Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium 

Gaksch, Martin; Jorde, Rolf; Grimnes, Guri; Joakimsen, Ragnar Martin; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; März, Winfried; Kleber, Marcus E.; Tomaschitz, Andreas; Grübler, Martin; Eiriksdottir, Gudny; Gudmundsson, Elias F.; Harris, Tamara B.; Cotch, Mary Frances; Aspelund, Thor; Gudnason, Vilmundur; Rutters, Femke; Beulens, Joline W.J.; Van't Riet, Esther; Nijpels, Giel; Dekker, Jacqueline M.; Grove-Laugesen, Diana; Rejnmark, Lars; Busch, Markus A.; Mensink, Gert B.M.; Scheidt-Nave, Christa; Thamm, Michael; Swart, Karin M.A.; Brouwer, Ingeborg A.; Lips, Paul; Van Schoor, Natasja M.; Sempos, Christopher T.; Durazo-Arvizu, Ramón A.; Škrabáková, Zuzana; Dowling, Kirsten G.; Cashman, Kevin D.; Kiely, Mairead; Pilz, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-16)
Background:<br>Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality.<br>Methods:<br>In a European ...
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Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study 

Lerstad, Gunhild; Brodin, Ellen Elisabeth; Enga, Kristin; Jorde, Rolf; Schirmer, Henrik; Njølstad, Inger; Svartberg, Johan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)
Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) ...
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The independent and joint associations of physical activity and body mass index with myocardial infarction: The Tromsø Study 

Renninger, Marius; Løchen, Maja-Lisa; Ekelund, Ulf; Hopstock, Laila Arnesdatter; Jørgensen, Lone; Mathiesen, Ellisiv B.; Njølstad, Inger; Schirmer, Henrik; Wilsgaard, Tom; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-13)
Physical activity and overweight are associated with myocardial infarction (MI). However, their joint association with MI remains unclear. Our objective was to examine the independent and joint association between leisuretime physical activity (LTPA), body mass index (BMI) and MI. This prospective cohort study included 16,572 men and women (47.5% women) aged 20–54 years who took part in the second ...
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CHA2DS2-VASc score, left atrial size and atrial fibrillation as stroke risk factors in the Tromsø Study 

Tiwari, Sweta; Løchen, Maja-Lisa; Jacobsen, Bjarne K.; Hopstock, Laila Arnesdatter; Nyrnes, Audhild; Njølstad, Inger; Mathiesen, Ellisiv B.; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-01)
Objective:<br> CHA2DS2-VASc score, left atrial (LA) size and atrial fibrillation (AF) have individually been associated with stroke risk. Our aim was to investigate the predictive ability of combinations of these factors for the odds of incident stroke in a population-based cohort study.<br> Methods:<br> We followed 2844 participants from the Tromsø Study from 1994 to 2012. Information on LA size ...
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