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High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study

Hald, Erin Mathiesen; Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)

High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but conflicting results have been reported on its role in venous thromboembolic disease. The objective of our study was to investigate the association between high-sensitivity C-reactive protein levels and risk of future venous thromboembolism in a prospective cohort recruited from a general population. ...

Obesity measures and risk of venous thromboembolism and myocardial infarction

Horvei, Lars Daae; Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

Venous thromboembolism increases the risk of atrial fibrillation: The tromsø study

Hald, Erin Mathiesen; Enga, Kristin Fjeldstad; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

N-Acetyl-β-D-Glucosaminidase Does Not Enhance Prediction of Cardiovascular or All-Cause Mortality by Albuminuria in a Low-Risk Population

Toft, Ingrid; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Eriksen, Bjørn Odvar; Melsom, Toralf; Njølstad, Inger; Wilsgaard, Tom; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)

Albuminuria is a well known risk factor for cardiovascular disease and mortality, but focus on renal tubular dysfunction as a potential risk factor is growing also. The association between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and cardiovascular risk has been assessed mostly in cross-sectional studies. We studied the cross-sectional associations between urinary NAG and cardiovascular ...

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Wu, Y; Waite, LL; Jackson, Anne U.; Sheu, WHH; Buyske, Steven; Absher, D; Arnett, DK; Boerwinkle, E; Bonnycastle, LL; Carty, CL; Cheng, I; Cochran, B; Croteau-Chonka, DC; Dumitrescu, L; Eaton, CB; Franceschini, N; Guo, XQ; Henderson, BE; Hindorff, LA; Kim, E; Kinnunen, L; Komulainen, P; Lee, WJ; Le Marchand, L; Lin, Y; Lindstrom, J; Holmen, Oddgeir; Mitchell, SL; Narisu, N; Robinson, JG; Schumacher, F; Stancaakovaa, A; Sundvall, J; Sung, YJ; Swift, AJ; Wang, WC; Wilkens, L; Wilsgaard, Tom; Young, AM; Adair, LS; Ballantyne, CM; Buzkova, P; Chakravarti, A; Collins, FS; Duggan, D; Feranil, AB; Ho, LT; Hung, YJ; Hunt, SC; Hveem, Kristian; Juang, JMJ; Kesaniemi, AY; Kuusisto, J; Laakso, M; Lakka, TA; Lee, IT; Leppert, MF; Matise, TC; Moilanen, L; Njølstad, Inger; Peters, U; Quertermous, T; Rauramaa, R; Rotter, JI; Saramies, J; Tuomilehto, J; Uusitupa, M; Wang, TD; Boehnke, M; Haiman, CA; Chen, YDI; Kooperberg, C; Assimes, TL; Crawford, DC; Hsiung, CA; North, KE; Mohlke, Karen L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)

Genome-wide association studies (GWAS) have identified ~ 100 loci associated with blood lipid levels, but much of the trait heritability remains unexplained, and at most loci the identities of the trait-influencing variants remain unknown. We conducted a trans-ethnic fine-mapping study at 18, 22, and 18 GWAS loci on the Metabochip for their association with triglycerides (TG), high-density ...

Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study

Jorde, Rolf; Schirmer, Henrik; Wilsgaard, Tom; Joakimsen, Ragnar Martin; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; Figenschau, Yngve; Berg, Jens Petter; Svartberg, Johan; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)

Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these ...

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

Randall, JC; Winkler, TW; Kutalik, Z; Berndt, SI; Jackson, AU; Monda, KL; Kilpelainen, TO; Esko, T; Magi, R; Li, SX; Workalemahu, T; Feitosa, MF; Croteau-Chonka, DC; Day, FR; Fall, T; Ferreira, T; Gustafsson, S; Locke, AE; Mathieson, I; Scherag, A; Vedantam, S; Wood, AR; Liang, LM; Steinthorsdottir, V; Thorleifsson, G; Dermitzakis, ET; Dimas, AS; Karpe, F; Min, JL; Nicholson, G; Clegg, DJ; Person, T; Krohn, JP; Bauer, S; Buechler, C; Eisinger, K; Bonnefond, A; Froguel, P; Hottenga, JJ; Prokopenko, I; Waite, LL; Harris, TB; Smith, AV; Shuldiner, AR; McArdle, WL; Caulfield, MJ; Munroe, PB; Gronberg, H; Chen, YDI; Li, G; Beckmann, JS; Johnson, T; Thorsteinsdottir, U; Teder-Laving, M; Khaw, KT; Wareham, NJ; Zhao, JH; Amin, N; Oostra, BA; Kraja, AT; Province, MA; Cupples, LA; Heard-Costa, NL; Kaprio, J; Ripatti, S; Surakka, I; Collins, FS; Saramies, J; Tuomilehto, J; Jula, A; Salomaa, V; Erdmann, J; Hengstenberg, C; Loley, C; Schunkert, H; Lamina, C; Wichmann, HE; Albrecht, E; Gieger, C; Hicks, AA; Johansson, A; Pramstaller, PP; Kathiresan, S; Speliotes, EK; Penninx, B; Hartikainen, AL; Jarvelin, MR; Gyllensten, U; Boomsma, DI; Campbell, H; Wilson, JF; Chanock, SJ; Farrall, M; Goel, A; Medina-Gomez, C; Rivadeneira, F; Estrada, K; Uitterlinden, AG; Hofman, A; Zillikens, MC; den Heijer, M; Kiemeney, LA; Maschio, A; Hall, P; Tyrer, J; Teumer, A; Volzke, H; Kovacs, P; Tonjes, A; Mangino, M; Spector, TD; Hayward, C; Rudan, I; Hall, AS; Samani, NJ; Attwood, AP; Sambrook, JG; Hung, J; Palmer, LJ; Lokki, ML; Sinisalo, J; Boucher, G; Huikuri, H; Lorentzon, M; Ohlsson, C; Eklund, N; Eriksson, JG; Barlassina, C; Rivolta, C; Nolte, IM; Snieder, H; Van der Klauw, MM; Van Vliet-Ostaptchouk, JV; Gejman, PV; Shi, JX; Jacobs, KB; Wang, ZM; Bakker, SJL; Leach, IM; Navis, G; van der Harst, P; Martin, NG; Medland, SE; Montgomery, GW; Yang, J; Chasman, DI; Ridker, PM; Rose, LM; Lehtimaki, T; Raitakari, O; Absher, D; Iribarren, C; Basart, H; Hovingh, KG; Hypponen, E; Power, C; Anderson, D; Beilby, JP; Hui, JN; Jolley, J; Sager, H; Bornstein, SR; Schwarz, PEH; Kristiansson, K; Perola, M; Lindstrom, J; Swift, AJ; Uusitupa, M; Atalay, M; Lakka, TA; Rauramaa, R; Bolton, JL; Fowkes, G; Fraser, RM; Price, JF; Fischer, K; KrjutAikov, K; Metspalu, A; Mihailov, E; Langenberg, C; Luan, JA; Ong, KK; Chines, PS; Keinanen-Kiukaanniemi, SM; Saaristo, TE; Edkins, S; Franks, PW; Hallmans, G; Shungin, D; Morris, AD; Palmer, CNA; Erbel, R; Moebus, S; Nothen, MM; Pechlivanis, S; Hveem, Kristian; Narisu, N; Hamsten, A; Humphries, SE; Strawbridge, RJ; Tremoli, E; Grallert, H; Thorand, B; Illig, T; Koenig, W; Muller-Nurasyid, M; Peters, A; Boehm, BO; Kleber, ME; Marz, W; Winkelmann, BR; Kuusisto, J; Laakso, M; Arveiler, D; Cesana, G; Kuulasmaa, K; Virtamo, J; Yarnell, JWG; Kuh, D; Wong, A; Lind, L; de Faire, U; Gigante, B; Magnusson, PKE; Pedersen, NL; Dedoussis, G; Dimitriou, M; Kolovou, G; Kanoni, S; Stirrups, K; Bonnycastle, LL; Njølstad, Inger; Wilsgaard, Tom; Ganna, A; Rehnberg, E; Hingorani, A; Kivimaki, M; Kumari, M; Assimes, TL; Barroso, IS; Boehnke, M; Borecki, IB; Deloukas, P; Fox, CS; Frayling, T; Groop, LC; Haritunians, T; Hunter, D; Ingelsson, E; Kaplan, R; Mohlke, KL; O'Connell, JR; Schlessinger, D; Strachan, DP; Stefansson, K; van Duijn, CM; Abecasis, GR; McCarthy, MI; Hirschhorn, JN; Qi, L; Loos, Ruth J.F.; Lindgren, CM; North, KE; Heid, IM (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total ...

Physical activity and risk of venous thromboembolism. The Tromsø Study

Borch, Knut Håkon; Hansen-Krone, Ida; Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study

Wilsgaard, Tom; Loehr, LR; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Bønaa, Kaare Harald; Njølstad, Inger; Heiss, G (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-06)

Background: The American Heart Association has proposed an impact goal for the year 2020 to improve cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed cardiovascular health metric score and incident myocardial infarction (MI) and to estimate the generalized impact fraction (GIF). <p>Methods: The health metric score was derived from ideal ...

Atrial fibrillation and future risk of venous thromboembolism:the Tromsø study

Enga, Kristin Fjeldstad; Rye Holmboe, Ina; Mathisen Hald, Erin; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)