Now showing items 1-8 of 8
Maternal serum concentrations of per- and polyfluoroalkyl substances and their predictors in years with reduced production and use
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background: Longitudinal monitoring studies of persistent organic pollutants (POPs) in human populations are important to better understand changes with time and age, and for future predictions. Objectives: We sought to describe serum POP time trends on an individual level, investigate age–period–cohort effects, and compare predicted polychlorinated biphenyl (PCB) concentrations to measured values. ...
Estimating Time-Varying PCB Exposures Using Person-Specific Predictions to Supplement Measured Values: A Comparison of Observed and Predicted Values in Two Cohorts of Norwegian Women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
Background: Studies on the health effects of polychlorinated biphenyls (PCBs) call for an understanding of past and present human exposure. Time-resolved mechanistic models may supplement information on concentrations in individuals obtained from measurements and/or statistical approaches if they can be shown to reproduce empirical data. <p>Objectives: Here, we evaluated the capability of one ...
Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01)
Background:<br>Disruption of thyroid homeostasis has been indicated in human studies targeting effects of persistent organic pollutants (POPs). Influence on the maternal thyroid system by POPs is of special interest during pregnancy because such effects could impair infant thyroid homeostasis.<br> Objectives:<br>We investigated the association between POPs and thyroid-stimulating hormone (TSH) ...
Thyroid homeostasis in mother–child pairs in relation to maternal iodine status. The MISA study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-24)
BACKGROUND/OBJECTIVES: Iodine deficiency during pregnancy may influence maternal and foetal thyroid function with the risk of causing neurocognitive and psychomotor deficits in the offspring. The objective of this study was to assess iodine status in pregnant women from Northern Norway and to investigate the influence of iodine status on maternal and infant thyroid function. <br>SUBJECTS/METHODS: ...
The impacts of emission trends of POPs on human concentration dynamics: Lessons learned from a longitudinal study in Norway (1979-2007)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-20)
Background. In this short communication, our focus is on the relationship between human concentrations of select persistent organic pollutants (POPs) and environmental emissions. It is based on a longitudinal study (1979-2007) conducted in Norway. Objectives. Our aim was to extract general insights from observed and predicted temporal trends in human concentrations of 49 POPs to assist in the design ...
Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04)
<p>The mechanisms involved in thyroid homeostasis are complex, and perfluoroalkyl substances (PFASs) have been indicated to interfere at several levels in this endocrine system. Disruption of the maternal thyroid homeostasis during early pregnancy is of particular concern, where subclinical changes in maternal thyroid hormones (THs) may affect embryonic and foetal development.</p> <p>The present ...
Overview of ongoing cohort and dietary studies in the Arctic
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-23)
This article gives an overview of the ongoing cohort and dietary studies underlying the assessment of population health in the Arctic. The emphasis here is on a description of the material, methods and results or preliminary results for each study. Detailed exposure information is available in an article in this journal, whereas another paper describes the effects associated with contaminant ...