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N-Acetyl-β-D-Glucosaminidase Does Not Enhance Prediction of Cardiovascular or All-Cause Mortality by Albuminuria in a Low-Risk Population 

Toft, Ingrid; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Eriksen, Bjørn Odvar; Melsom, Toralf; Njølstad, Inger; Wilsgaard, Tom; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)
Albuminuria is a well known risk factor for cardiovascular disease and mortality, but focus on renal tubular dysfunction as a potential risk factor is growing also. The association between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and cardiovascular risk has been assessed mostly in cross-sectional studies. We studied the cross-sectional associations between urinary NAG and cardiovascular ...
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Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study 

Melsom, Toralf; Schei, Jørgen; Stefansson, Vidar Tor Nyborg; Solbu, Marit Dahl; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Wilsgaard, Tom; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29)
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Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study 

Melsom, Toralf; Schei, Jørgen; Stefansson, Vidar Tor Nyborg; Solbu, Marit Dahl; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Wilsgaard, Tom; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29)
Background: The role of prediabetes as a risk factor for hyperfiltration and albuminuria in persons who do not develop diabetes is unclear. The lack of evidence is mainly due to the difficulty of accurately assessing the glomerular filtration rate (GFR) in the near-normal range of GFR. We investigated whether prediabetes is an independent risk factor for glomerular hyperfiltration and high-normal ...
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Cystatin C and cardiovascular disease: a Mendelian randomization study 

van der Laan, Sander W; Fall, Tove; Sourmare, Aicha; Teumer, Alexander; Sedaghat, Sanaz; Baumert, Jens; Zahaneh, Delilah; van Setten, Jessica; Isgum, Ivana; Galesloot, Tessel E.; Arpegård, Johannes; Amouyel, Philippe; Trompet, Stella; Waldenberger, Melanie; Dörr, Marcus; Magnusson, Patrik K.; Giedraitis, Vilmantas; Larsson, Anders; Morris, Andrew P.; Felix, Janine F.; Morrison, Alanna C.; Franceschini, Nora; Bis, Joshua C.; Kavousi, Maryam; O'Donnell, Christopher J.; Drenos, Fotios; Tragante, Vinicius; Munroe, Patricia B.; Malik, Rainer; Dichgans, Martin; Worrall, Bradford B.; Erdmann, Jeanette; Nelson, Christopher P.; Samani, Nilesh J.; Schunkert, Heribert; Marchini, Jonathan; Patel, Riyaz S.; Hingorani, Aroon D.; Lind, Lars; Pedersen, Nancy L.; de Graaf, Jacqueline; Kiemeney, Lambertus A.L.M.; Baumeister, Sebastian E.; Franco, Oscar H.; Hofman, Albert; Uitterlinden, André G.; Koenig, Wolfgang; Meisinger, Christa; Peters, Annette; Thorand, Barbara; Jukema, J.Wouter; Eriksen, Bjørn Odvar; Toft, Ingrid; Wilsgaard, Tom; Onland-Moret, N. Charlotte; van der Schouw, Yvonne T.; Debette, Stéphanie; Kumari, Meena; Svensson, Per; van der Harst, Pim; Kivimäki, Mika; Keating, Brendan J.; Sattar, Naveed; Dehghan, Abbas; Reiner, Alex P.; Ingelsson, Erik; Den Ruijter, Hester M.; de Bakker, Paul I.W.; Pasterkamp, Gerard; Ärnlöv, Johan; Holmes, Michael V.; Asselbergs, Folkert W. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-30)
BACKGROUND<br> Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation.<br> OBJECTIVES<br>The aim of this study was to use Mendelian randomization ...
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Elevated blood pressure is not associated with accelerated glomerular filtration rate decline in the general non-diabetic middle-aged population 

Eriksen, Bjørn Odvar; Stefansson, Vidar Tor Nyborg; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Schei, Jørgen; Solbu, Marit Dahl; Wilsgaard, Tom; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-14)
Although hypertension is a risk factor for end-stage renal disease, this complication develops in only a minority of hypertensive patients. Whether non-malignant hypertension itself is sufficient to cause reduced glomerular filtration rate (GFR) is unclear. We investigated whether elevated blood pressure (BP) was associated with accelerated GFR decline in the general population. The study ...
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Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994-2013 

Norvik, Jon Viljar; Schirmer, Henrik; Ytrehus, Kirsti; Storhaug, Hilde-Merete; Jenssen, Trond Geir; Eriksen, Bjørn Odvar; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Wilsgaard, Tom; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-31)
Aims: To investigate whether serum uric acid predicts adverse outcomes in persons with indices of diastolic dysfunction in a general population. <br>Methods and results: We performed a prospective cohort study among 1460 women and 1480 men from 1994 to 2013. End- points were all-cause mortality, incident myocardial infarction, and incident ischaemic stroke. We strati fi ed the analyses ...
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Blood pressure and age-related GFR decline in the general population 

Eriksen, Bjørn Odvar; Stefansson, Vidar Tor Nyborg; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Schei, Jørgen; Solbu, Marit Dahl; Wilsgaard, Tom; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-28)
Background: <br> Hypertension is one of the most important causes of end-stage renal disease, but it is unclear whether elevated blood pressure (BP) also accelerates the gradual decline in the glomerular filtration rate (GFR) seen in the general population with increasing age. The reason may be that most studies have considered only baseline BP and not the effects of changes in BP, antihypertensive ...
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Mild Albuminuria Is a Risk Factor for Faster GFR Decline in the Nondiabetic Population 

Melsom, Toralf; Solbu, Marit Dahl; Schei, Jørgen; Stefansson, Vidar Tor Nyborg; Norvik, Jon Viljar; Jenssen, Trond Geir; Wilsgaard, Tom; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)
<i>Introduction</i>: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, ...

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Filter by Date Issued2018 (1)2017 (2)2016 (2)2015 (3)Filter by Document TypeJournal article (8)Peer reviewed (8)Tidsskriftartikkel (8)Filter by Author
Eriksen, Bjørn Odvar (8)
Wilsgaard, Tom (8)
Jenssen, Trond Geir (7)Melsom, Toralf (6)Solbu, Marit Dahl (6)Schei, Jørgen (5)Stefansson, Vidar Tor Nyborg (5)Mathisen, Ulla Dorte (4)Løchen, Maja-Lisa (2)Mathiesen, Ellisiv B. (2)... View More
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