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Elevated blood pressure is not associated with accelerated glomerular filtration rate decline in the general non-diabetic middle-aged population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-14)
Although hypertension is a risk factor for end-stage renal disease, this complication develops in
only a minority of hypertensive patients. Whether non-malignant hypertension itself is sufficient
to cause reduced glomerular filtration rate (GFR) is unclear. We investigated whether elevated
blood pressure (BP) was associated with accelerated GFR decline in the general population. The
study ...
Blood pressure and age-related GFR decline in the general population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-28)
Background: <br> Hypertension is one of the most important causes of end-stage renal disease, but it is unclear
whether elevated blood pressure (BP) also accelerates the gradual decline in the glomerular filtration rate (GFR)
seen in the general population with increasing age. The reason may be that most studies have considered only
baseline BP and not the effects of changes in BP, antihypertensive ...
Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29)
Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29)
Background: The role of prediabetes as a risk factor for hyperfiltration and albuminuria in persons who do
not develop diabetes is unclear. The lack of evidence is mainly due to the difficulty of accurately assessing the
glomerular filtration rate (GFR) in the near-normal range of GFR. We investigated whether prediabetes is an
independent risk factor for glomerular hyperfiltration and high-normal ...
N-Acetyl-β-D-Glucosaminidase Does Not Enhance Prediction of Cardiovascular or All-Cause Mortality by Albuminuria in a Low-Risk Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)
Albuminuria is a well known risk factor for cardiovascular disease and mortality, but focus on renal tubular dysfunction as a potential risk factor is growing also. The association between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and cardiovascular risk has been assessed mostly in cross-sectional studies. We studied the cross-sectional associations between urinary NAG and cardiovascular ...
Mild Albuminuria Is a Risk Factor for Faster GFR Decline in the Nondiabetic Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)
<i>Introduction</i>: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease
and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular
filtration rate (GFR) decline in a cohort from the general population without diabetes, ...