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Circulating RANKL and RANKL/OPG and breast cancer risk by ER and PR subtype: Results from the EPIC cohort.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-31)
Receptor activator of nuclear factor-kappa B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer risk via activation of RANK signaling; this may be modulated by osteoprotegerin (OPG), the decoy receptor for RANKL. sRANKL and breast cancer risk by hormone receptor subtype has ...
Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-04)
Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and
progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer
are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited
385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs ...
Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
Background: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
<br>Methods: Over half a million ...
Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Nutrient patterns and their food sources in an international study setting: Report from the EPIC study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Dietary fatty acids, macronutrient substitutions, food sources and incidence of coronary heart disease: Findings from the EPIC-CVD case-cohort study across nine european countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-07)
BACKGROUND: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids
[SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically,
the relevance of food sources of SFAs to CHD associations is uncertain.<p>
METHODS AND RESULTS: We conducted a case-cohort study involving 10 529 ...
Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-02)
<i>Background</i>
- Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some established risk factors for invasive breast cancer have a similar impact on BCIS risk, but large population-based studies on lifestyle factors and BCIS risk are lacking. Thus, ...
Evaluation of protein and amino acid intake estimates from the EPIC dietary questionnaires and 24-h dietary recalls using different food composition databases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-20)
Background and aims: This study aimed to expand the European Prospective Investigation into Cancer and Nutrition (EPIC) nutrient database (ENDB) by adding amino acid (AA)
values, using the U.S. nutrient database (USNDB). Additionally, we aimed to evaluate these
new protein and AA intake estimates from the EPIC dietary questionnaires (DQ) and 24-
h dietary recalls (24-HDR) using different matching ...
Vitamin D-related genes, blood vitamin D levels and colorectal cancer risk in Western European populations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-20)
Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, ...
Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-30)
Background: Reproductive events are associated with important physiologic changes, yet little is known about
how reproductive factors influence long-term health in women. Our objective was to assess the relation of reproductive
characteristics with all-cause and cause-specific mortality risk.
<p>Methods: The analysis was performed within the European Investigation into Cancer and Nutrition ...